A systematic review on the prevalence of extended-spectrum beta lactamase-producing Gram-negative bacteria in Nigeria

Tanko, Nuhu; Bolaji, Rebecca Olajumoke; Olayinka, Adebola; Olayinka, Busayo Olalekan

doi:10.1016/j.jgar.2020.04.010

Cited by 25 publications

(23 citation statements)

References 46 publications

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“…In Nigeria, rates as low as 24% and as high as 100% have been reported (Igwe et al 2016 ; Agbagwa and Aminofifori 2017 ; Nwafia et al 2019 ; Onanuga et al 2019 ; Ugwu et al 2020 ). A 2020 review on ESBL in Nigeria reported rates ranging from 7.5% to 82.3% with rates as low as 8.1% observed from the same region as this present study (Tanko et al 2020 ). Low rates of prevalence have been linked with several regions worldwide, especially the north/eastern European countries.…”

Section: Discussionsupporting

confidence: 70%

“…Those belonging to the SHV, TEM and CTX-M families have, however, been described as the most commonly encountered among clinical isolates (Bradford 2001 ; Mahamat et al 2019 ; Malande et al 2019 ). A recent review study (Tanko et al 2020 ) on ESBL-producing Gram-negative bacteria in Nigeria similarly reports on the detection of these predominant ESBL genes. The study carried out between January 2004 and November 2019 retrieved 217 articles published within that time period, but only 60 reported on both the phenotypic and genotypic detection of ESBL production in human isolates.…”

Section: Introductionmentioning

confidence: 99%

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Antibiotic resistance and ESBL production in Escherichia coli from various sources in Aba metropolis, Nigeria

2021

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Background The increase in multidrug resistance (MDR) among pathogenic bacteria responsible for infectious diseases has led to lack of effectiveness of some antibiotics. The ability of Escherichia coli to harbor resistant genes has made the treatment of infections a major challenge. This study was carried out to assess antibiotic resistance and extended-spectrum beta-lactamase (ESBL) production of E. coli from various sources in Aba metropolis, Nigeria. Results From a total of 350 samples collected from clinical and non-clinical sources, 137 were presumptively identified as E. coli by standard phenotypic methods and 83 were confirmed as E. coli by the detection of E. coli specific 16S rRNA gene fragments. The majority of these isolates (52, 62.7%) were from non-clinical sources. The clinical isolates, however, exhibited a higher level of resistance against 62.5% of tested antibiotics. Both group of isolates exhibited similar levels (58.1% vs 53.9%) of MDR, though. A low rate of ESBL production was observed (1.2%) following phenotypic detection of ESBL-producing abilities using the double-disc synergy test. An assessment of the presence of three beta-lactamase gene genotypes (blaTEM, blaSHV and blaCTX-M) revealed that none of the three predominant ESBL genotypes was identified in this study. Conclusions This study reports high levels of antibiotic resistance in both clinical and non-clinical E. coli isolates. Though higher rates of resistance were observed among the non-clinical isolates, both group of organisms had similar levels of MDR. Strikingly, however, was the low level of ESBL producers detected in this study and the absence of the three main genotypes associated with ESBL production in this study.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance and ESBL production in Escherichia coli from various sources in Aba metropolis, Nigeria

2021

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“…The emergence of bacteria that contain the extended-spectrum beta-lactamases (ESBLs) and the Ambler class C lactamases (AmpC) has compounded this problem and has become a global concern. Whereas many studies on the detection of ESBL in Gram-negative bacteria in Nigeria, there are regions where the cases are still under-reported and the prevalence still unclear (Tanko et al, 2020). This study aimed to determine the occurrence of these enzymes in the clinical setting and examine the presence of ESBL and AmpC producing isolates among environmental samples in Ebonyi and Enugu state's rural areas.…”

Section: The Present Studymentioning

confidence: 98%

“…Over the years, antibiotics have been among the primary drugs used to treat or prevent infections in animals and humans (Tanko et al, 2020). Perhaps, the rapid and irrepressible increase in antimicrobial resistance of pathogenic bacteria that have been observed over the last two decades is widely accepted to be one of the major problems of human medicine today (Gniadkowski, 2001).…”

Section: …………………………………………………………………………………………………… Introduction: -mentioning

confidence: 99%

“…549 methicillin-and carbapenem-resistant bacteria (Tanko et al, 2020). On the other hand, Ambler class C (Amp C) beta-lactamases are cephalosporinanses that are poorly inhibited by clavulanic acid and can be differentiated from ESBLs ability to hydrolyze cephamycins as well as other extended-spectrum cephalosporins.…”

Section: …………………………………………………………………………………………………… Introduction: -mentioning

confidence: 99%

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The Prevalence of Extended-Spectrum Beta-Lactamases and Ambler Class C Beta-Lactamases in Enugu and Ebonyi States of Nigeria

Eze¹

2021

IJAR

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Over the years, antibiotics have been among the primary drugs used to treat or prevent infections in animals and humans. Over the years, ESBL and AmpC producing isolates have become common microorganisms in medical institutions. They have contributed immensely to the clinical challenges caused by nosocomial infections with minimal therapeutic options.The present study investigated the prevalence of extended-spectrum beta-lactamases and Ambler class C beta-lactamases in the Enugu and Ebonyi States of Nigeria. A total of fifty isolates comprising 27 clinical and 23 environmental isolates were screened and observed for the presence of ESBL and AmpC producing isolates. The production of either of the two enzymes was detected by observing zones of inhibition in diameter. The findings showed the presence of ESBL and AmpC producing isolates in the clinical and environmental samples tested. The study concludes that ESBL and AmpC beta-lactamases production by resistant bacterial isolates (especially the Gram-negatives) remain the prevalent mechanism in bacterial resistance to beta-lactam drugs. The study recommends that adequate and appropriate detection and monitoring of ESBL and AmpC producing enzymes within the communities.

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Antibiotic Resistance Status of Pseudomonas aeruginosa in Clinical Isolates in Ogun State

Ohore

Akinduti

Ahuekwe

et al. 2022

Bioenergy and Biochemical Processing Technologies

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Pathogenic Gram-negative bacteria mostly produce extended-spectrum beta-lactamases (ESBLs), a feature that confers resistance to some newer generations of antibiotics. The study was aimed at evaluating the antibiotic resistance status of Pseudomonas aeruginosa isolates collected from September to November 2020 from tertiary care hospitals in Ogun State, Nigeria. One hundred fifty isolates from clinical samples (high vaginal swab, wound, urine, ear, blood) were obtained, and their susceptibility pattern was determined against eight antibiotics. Out of the 150 samples, 27 P. aeruginosa were identified. Anti-microbial susceptibility testing was carried out on the isolates using the modified Kirby-Bauer disc diffusion method, and ESBL production was detected phenotypically. The mean age group of the patients was 29.56 years. Gentamicin from the aminoglycoside class showed best activity (74.1%), and ampicillin and penicillin showed little to no activity (100% and 96.3%, respectively). Cephalosporins, ceftazidime and cefuroxime were 100% resistant, while the fluoroquinolones Ciprofloxacin and Ofloxacin had a mean resistance of 40.7%. The moderate active antibiotic was streptomycin (44.4% susceptible). The poor monitoring of antibiotic usage, the abuse of their availability and the acquisition of resistance elements by organisms in hospitals and the community may be the causes of high antibiotic resistance. Keywords Antibiotic resistance  Hospitals  Pseudomonas aeruginosa This is a preview of subscription content, access via your institution.

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A systematic review on the prevalence of extended-spectrum beta lactamase-producing Gram-negative bacteria in Nigeria

Cited by 25 publications

References 46 publications

Antibiotic resistance and ESBL production in Escherichia coli from various sources in Aba metropolis, Nigeria

Antibiotic resistance and ESBL production in Escherichia coli from various sources in Aba metropolis, Nigeria

The Prevalence of Extended-Spectrum Beta-Lactamases and Ambler Class C Beta-Lactamases in Enugu and Ebonyi States of Nigeria

Antibiotic Resistance Status of Pseudomonas aeruginosa in Clinical Isolates in Ogun State

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