A Systematic Review on the Association between Obesity and Mood Disorders and the Role of Gut Microbiota

Panda, Swati Sagarika; Nayak, Akankshya; Shah, Srishti; Aich, Palok

doi:10.3390/metabo13040488

Cited by 6 publications

(4 citation statements)

References 118 publications

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“…The gut microbiota-brain axis, which is bidirectional and plays a critical role in brain development, has been linked to the brain in numerous studies. This association is known as the gut microbiota-brain axis [93]. Lower levels of BDNF have been reported in patients with AD.…”

Section: Admentioning

confidence: 99%

A Review on the Protective Effects of Probiotics against Alzheimer’s Disease

Mishra,

Yadav,

Solanki

et al. 2023

Biology

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This review summarizes the protective effects of probiotics against Alzheimer’s disease (AD), one of the most common neurodegenerative disorders affecting older adults. This disease is characterized by the deposition of tau and amyloid β peptide (Aβ) in different parts of the brain. Symptoms observed in patients with AD include struggles with writing, speech, memory, and knowledge. The gut microbiota reportedly plays an important role in brain functioning due to its bidirectional communication with the gut via the gut–brain axis. The emotional and cognitive centers in the brain are linked to the functions of the peripheral intestinal system via this gut–brain axis. Dysbiosis has been linked to neurodegenerative disorders, indicating the significance of gut homeostasis for proper brain function. Probiotics play an important role in protecting against the symptoms of AD as they restore gut–brain homeostasis to a great extent. This review summarizes the characteristics, status of gut–brain axis, and significance of gut microbiota in AD. Review and research articles related to the role of probiotics in the treatment of AD were searched in the PubMed database. Recent studies conducted using animal models were given preference. Recent clinical trials were searched for separately. Several studies conducted on animal and human models clearly explain the benefits of probiotics in improving cognition and memory in experimental subjects. Based on these studies, novel therapeutic approaches can be designed for the treatment of patients with AD.

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Section: Admentioning

confidence: 99%

A Review on the Protective Effects of Probiotics against Alzheimer’s Disease

Mishra,

Yadav,

Solanki

et al. 2023

Biology

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“…In addition, the gut microbiota plays a significant role in regulating various physiological processes that affect both obesity and MDD [ 80 ]. An imbalance in the microbial community, known as gut dysbiosis, has been implicated as a significant factor in the development of both conditions.…”

Section: The Interplay Between Depression Obesity and Metabolic Dysre...mentioning

confidence: 99%

Personalized Medicine of Omega-3 Fatty Acids in Depression Treatment in Obese and Metabolically Dysregulated Patients

Chen

Chang

et al. 2023

JPM

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The co-occurrence of depression and obesity has become a significant public health concern worldwide. Recent studies have shown that metabolic dysfunction, which is commonly observed in obese individuals and is characterized by inflammation, insulin resistance, leptin resistance, and hypertension, is a critical risk factor for depression. This dysfunction may induce structural and functional changes in the brain, ultimately contributing to depression’s development. Given that obesity and depression mutually increase each other’s risk of development by 50–60%, there is a need for effective interventions that address both conditions. The comorbidity of depression with obesity and metabolic dysregulation is thought to be related to chronic low-grade inflammation, characterized by increased circulating levels of pro-inflammatory cytokines and C-reactive protein (CRP). As pharmacotherapy fails in at least 30–40% of cases to adequately treat major depressive disorder, a nutritional approach is emerging as a promising alternative. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are a promising dietary intervention that can reduce inflammatory biomarkers, particularly in patients with high levels of inflammation, including pregnant women with gestational diabetes, patients with type 2 diabetes mellitus, and overweight individuals with major depressive disorder. Further efforts directed at implementing these strategies in clinical practice could contribute to improved outcomes in patients with depression, comorbid obesity, and/or metabolic dysregulation.

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“…Excess adiposity elevates the risk of health complications including cardiovascular disease, metabolic dysfunction (Type 2 diabetes, nonfat liver disease, hypertension) and cancers [ 2 ]. It also increases the risk of functional limitations and psychological complications, including anxiety, depression, and mood disorders [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

‘Beyond the Scale’: A Qualitative Exploration of the Impact of Weight Stigma Experienced by Patients With Obesity in General Practice

Ryan,

Quigley,

Birney

et al. 2024

Health Expectations

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ObjectiveObesity is a complex, chronic, relapsing disease that requires an individualised approach to treatment. However, weight stigma (WS) experienced in healthcare settings poses a significant barrier to achieving person‐centred care for obesity. Understanding the experiences of people living with obesity (PwO) can inform interventions to reduce WS and optimise patient outcomes. This study explores how patients with obesity perceive WS in general practice settings; its impact on their psychological well‐being and health behaviours, and the patients suggestions for mitigating it.MethodsIn‐depth semistructured interviews were conducted with 11 PwO who had experienced WS in general practice settings in Ireland. The interviews were conducted online via Zoom between May and August 2023; interviews lasted between 31 and 63 min (M = 34.36 min). Interviews were audio‐recorded, transcribed verbatim and analysed using inductive reflexive thematic analysis.ResultsThree overarching themes specific to participants' experience of WS in general practice were generated: (1) shame, blame and ‘failure’; (2) eat less, move more—the go‐to treatment; (3) worthiness tied to compliance. A fourth theme: (4) the desire for a considered approach, outlines the participants' suggestions for reducing WS by improving the quality of patient–provider interactions in general practice.ConclusionThe findings call for a paradigm shift in the management of obesity in general practice: emphasising training for GPs in weight‐sensitive communication and promoting respectful, collaborative, and individualised care to reduce WS and improve outcomes for people with obesity.Patient or Public ContributionPPI collaborators played an active and equal role in shaping the research, contributing to the development of the research questions, refining the interview schedule, identifying key themes in the data, and granting final approval to the submitted and published version of the study.

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A Systematic Review on the Association between Obesity and Mood Disorders and the Role of Gut Microbiota

Cited by 6 publications

References 118 publications

A Review on the Protective Effects of Probiotics against Alzheimer’s Disease

A Review on the Protective Effects of Probiotics against Alzheimer’s Disease

Personalized Medicine of Omega-3 Fatty Acids in Depression Treatment in Obese and Metabolically Dysregulated Patients

‘Beyond the Scale’: A Qualitative Exploration of the Impact of Weight Stigma Experienced by Patients With Obesity in General Practice

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