A systematic review on the critical size defect model

Vajgel, André; Mardas, Nikos; Farias, Bruna de Carvalho; Petrie, Aviva; Cimões, Renata; Donos, Nikolaos

doi:10.1111/clr.12194

Cited by 178 publications

(170 citation statements)

References 76 publications

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“…This evolution pattern was also observed in other experimental in vivo studies 18,27 and pointed out in a recent review on critical size calvarial defects in rats 19 .…”

Section: Discussionsupporting

confidence: 83%

“…The experimental animal model employed in this study of bilateral parietal 5mm craniotomies has been frequently used due to its favorable characteristics, the main one being the ability to produce paired analysis. It also fulfills the criteria for a critical size defect, and allows for the evaluation of biomaterials for bone reconstruction 15,18,19 .…”

Section: Discussionmentioning

confidence: 99%

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Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

et al. 2014

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PURPOSE:To investigate the osseointegration properties of prototyped implants with tridimensionally interconnected pores made of the Ti 6 Al 4 V alloy and the influence of a thin calcium phosphate coating. METHODS:Bilateral critical size calvarial defects were created in thirty Wistar rats and filled with coated and uncoated implants in a randomized fashion. The animals were kept for 15, 45 and 90 days. Implant mechanical integration was evaluated with a push-out test.Bone-implant interface was analyzed using scanning electron microscopy. RESULTS:The maximum force to produce initial displacement of the implants increased during the study period, reaching values around 100N for both types of implants. Intimate contact between bone and implant was present, with progressive bone growth into the pores. No significant differences were seen between coated and uncoated implants. CONCLUSION:Adequate osseointegration can be achieved in calvarial reconstructions using prototyped Ti 6 Al 4 V Implants with the described characteristics of surface and porosity.

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“…This evolution pattern was also observed in other experimental in vivo studies 18,27 and pointed out in a recent review on critical size calvarial defects in rats 19 .…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

et al. 2014

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“…(Messora et al, 2008;Park et al 2009;Scothford et al, 2011). Outros estudos (Donos et al, 2004;Furlaneto et al, 2007;Mardas et al, 2008;Cunha et al, 2014; e uma recente revisão sistemática consideraram que defeitos com 5 mm de diâmetro em calvária de ratos são de tamanho crítico (Vajgel et al, 2014). Portanto, se um menor defeito pode ser realizado e ser considerado DTC, significa menor morbidade ao animal e deve ser a opção de escolha.…”

Section: Modelo Experimentalunclassified

“…O modelo animal (roedores) por sua vez, apresenta vantagens por permitir padronização devido a similaridade genética, fácil manuseio e melhor custo-benefício frente a utilização de outros modelos animais (Vajgel et al, 2014).…”

Section: Grupo Média Das Diferençasunclassified

“…Alguns autores realizam mais de um defeito na calvária do mesmo animal (Donos et al, 2004;Ghahroudi et al, 2014) com a finalidade de reduzir o número de animais utilizados no estudo (Vajgel et al, 2014), outros realizam um defeito único (Furlaneto et al, 2007;Cunha et al, 2014), que é desejável em estudos que utilizam o laser como tratamento evitando o seu efeito sistêmico (Rockind et al, 1989;Gerbi et al, 2005).…”

Section: Grupo Média Das Diferençasunclassified

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Avaliação de diferentes protocolos de aplicação do laser de baixa intensidade associado ou não ao osso bovino inorgânico (Bio-Oss®) na cicatrização de defeitos ósseos criados cirurgicamente em calvárias de ratos. Estudo histológico e hist

Sbrana¹

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Bone, Stem Cells and Regeneration: Tissue Engineering Approaches

Grigoriadis

2021

Encyclopedia of Life Sciences

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The potential for regenerating bone and cartilage for cell‐based therapies has increased markedly in the past decades primarily due to advances in the understanding of molecular controls of embryonic skeletal development, in identification of refined stem cell/progenitor populations that are suitable for tissue regeneration, and in the discoveries of novel biomaterials that can mimic tissue architecture. In particular, modelling how the embryo makes the appropriate molecular decisions to fine tune the development of specific bone and cartilage subpopulations that form the complex skeleton has provided a platform upon which regenerative strategies can be translated to the clinic. It is, therefore, imperative to understand the basic biology of bone and skeletal tissues and apply lessons from developmental biology to identify the unique and appropriate cell populations that have potent regenerative potential when combined with optimal biomaterials. Key Concepts Bone/cartilage tissue engineering requires interaction between stem cells and biomaterials. Choosing the appropriate stem cell populations is extremely important and depends on the biological application studies. The use of directed differentiation of pluripotent stem cells that mimic developmental processes is an important advance in tissue engineering. Choosing the appropriate biomaterial with specific tunable properties is essential for supporting stem cell differentiation. Three‐dimensional approaches for tissue formation are important for translational studies. Defined preclinical models are necessary for screening stem cell/biomaterials constructs.

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A systematic review on the critical size defect model

Abstract: Calvarial defects with a diameter of 5.0 mm could be considered as a CSD. However, there is a necessity for further standardization of the rat calvaria model to enable more accurate comparison among future studies.

Cited by 178 publications

References 76 publications

Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

Paired evaluation of calvarial reconstruction with prototyped titanium implants with and without ceramic coating

Avaliação de diferentes protocolos de aplicação do laser de baixa intensidade associado ou não ao osso bovino inorgânico (Bio-Oss®) na cicatrização de defeitos ósseos criados cirurgicamente em calvárias de ratos. Estudo histológico e hist

Bone, Stem Cells and Regeneration: Tissue Engineering Approaches

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