Both biomaterials partially preserved the width and the interproximal bone height of the alveolar ridge.

Within the limits of the systematic review there was evidence that the evaluated augmentation techniques result in similar implant survival between augmented and pristine sites. The small number of retrieved studies fulfilling the inclusion criteria limited the conclusions regarding the success of the augmentation and its effect on the survival of the implants. Properly designed randomized controlled clinical trials on this topic are needed.

This systematic review reports not only on the clinical and radiographic outcomes, but also evaluates the histological appearance of the socket, along with site specific factors, patient-reported outcomes, feasibility of implant placement and strength of evidence, which will facilitate the decision making process in the clinical practice.

ARP results in a significant reduction in the vertical bone dimensional change following tooth extraction when compared to unassisted socket healing. The reduction in horizontal alveolar bone dimensional change was found to be variable. No evidence was identified to clearly indicate the superior impact of a type of ARP intervention (GBR, socket filler and socket seal) on bone dimensional preservation, bone formation, keratinised tissue dimensions and patient complications.

Calvarial defects with a diameter of 5.0 mm could be considered as a CSD. However, there is a necessity for further standardization of the rat calvaria model to enable more accurate comparison among future studies.