A Systematic Review: Performance of Rapid Diagnostic Tests for the Detection of Plasmodium knowlesi, Plasmodium malariae, and Plasmodium ovale Monoinfections in Human Blood

Yerlikaya, Seda; Campillo, Ana; González, Iveth J.

doi:10.1093/infdis/jiy150

Cited by 55 publications

(43 citation statements)

References 63 publications

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“…LDH can be divided into three categories: Pf-specific, Pv-specific and pan-specific. Antibodies against these antigens can be combined in one type of RDTs to detect different Plasmodium species [9,10]. According to Bell and his colleagues, RDTs can be divided into 7 types depending on their target antigens (Appendix S1 in the Online Supplementary Document) [11].…”

Section: Viewpoints Papersmentioning

confidence: 99%

High value of rapid diagnostic tests to diagnose malaria within children: A systematic review and meta-analysis

Zhu

Ling

Shang

et al. 2020

Journal of Global Health

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High value of rapid diagnostic tests to diagnose malaria within children: A systematic review and meta-analysis Background Children aged under five years accounted for 61% of all malaria deaths worldwide in 2017, and quicker differential diagnosis of malaria fever is vital for them. Rapid diagnostic tests (RDTs) are strips to detect Plasmodium-specific antigens promptly and are helpful in resource-limited areas. Thus, our aim is to assess the diagnostic accuracy of RDTs for malaria in children against the gold standard. Methods MEDLINE, Web of Science, EMBASE, Cochrane Library, the China National Knowledge Infrastructure, Wanfang, and Sinomed databases were systematically searched on August 23, 2019. Studies that compared RDTs with microscopy or polymerase chain reaction in malaria diagnoses for children were eligible. Relevant data were extracted. The quality of studies was evaluated using the revised Quality Assessment of Diagnostic Accuracy Studies instrument. Meta-analyses were carried out to calculate the pooled estimates and 95% confidence intervals of sensitivity and specificity. Results 51 articles were included. For diagnostic accuracy, the pooled estimates of the sensitivity and specificity of RDTs were 0.93 (95% confidence interval (CI) = 0.90, 0.95) and 0.93 (95% CI = 0.90, 0.96) respectively. Studies were highly heterogeneous, and subgroup analyses showed that the application of RDTs in high malaria transmission areas had higher sensitivity but lower specificity than those in low-to-moderate areas. Conclusions RDTs have high accuracy for malaria diagnosis in children, and this characteristic is more prominent in high transmission areas. As they also have the advantages of rapid-detection, are easy-to-use, and can be cost-effective, it is recommended that the wider usage of RDTs should be promoted, especially in resource-limited areas. Further research is required to assess their performance in WHO SouthEast Asia and Americas Region. Electronic supplementary material: The online version of this article contains supplementary material.

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Section: Viewpoints Papersmentioning

confidence: 99%

High value of rapid diagnostic tests to diagnose malaria within children: A systematic review and meta-analysis

Zhu

Ling

Shang

et al. 2020

Journal of Global Health

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“…A previous systematic review of 33 articles published between 1922 and 2015 demonstrated that a total of five out of 22 severe cases of P. ovale malaria were fatal, and two cases of congenital P. ovale malaria were fatal [29]. A more recent systematic review conducted by Yerlikaya et al in 2018 demonstrated that a RDT had poor performance in detecting P. ovale because P. ovale infections usually occur at very low parasite densities, leading to missed detection by microscopy and RDTs [30]. Nevertheless, studies on the prevalence of severe P. ovale malaria provide more information on this neglected species and are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

Severity and mortality of severe Plasmodium ovale infection: A systematic review and meta-analysis

Kotepui

Milanez

et al. 2020

PLoS ONE

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Plasmodium ovale can infect humans, causing malaria disease. We aimed to investigate the severity and mortality of severe P. ovale infection to increase the awareness of physicians regarding the prognosis of this severe disease and outcome-related deaths in countries in which this disease is endemic. Articles that were published in the PubMed, Scopus, and ISI Web of Science databases prior to January 5, 2020 and reported the prevalence of severe P. ovale infection were systematically searched and reviewed. Studies that mainly reported severe P. ovale infection according to the 2014 WHO criteria for the treatment of malaria were included. Two reviewers selected, identified, assessed, and extracted data from studies independently. The pooled prevalence of severe P. ovale mono-infections was estimated using the command "metaprop case population, random/fixed", which yielded the pooled estimate, 95% confidence interval (CI) and the I 2 value, indicating the level of heterogeneity. Meta-analyses of the proportions were performed using a random-effects model to explore the different proportions of severity between patients with P. ovale and those with other Plasmodium species infections. Among the eight studies that were included and had a total of 1,365 ovale malaria cases, the pooled prevalence of severe P. ovale was 0.03 (95% CI = 0.03-0.05%, I 2 = 54.4%). Jaundice (1.1%), severe anemia (0.88%), and pulmonary impairments (0.59%) were the most common severe complications found in patients infected with P. ovale. The meta-analysis demonstrated that a smaller proportion of patients with P. ovale than of patients with P. falciparum had severe infections (P-value = 0.01, OR = 0.36, 95% CI = 0.16-0.81, I 2 = 72%). The mortality rate of severe P. ovale infections was 0.15% (2/1,365 cases). Although severe complications of P. ovale infections in patients are rare, it is very important to increase the awareness of physicians regarding the prognosis of severe P. ovale infections in patients, especially in a high-risk population.

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“…The performance of RDTs for detecting knowlesi malaria has not been thoroughly investigated, but their sensitivity is known to be suboptimal. 5,6 In a recent systematic review, although the accumulated evidence is not sufficient, the overall sensitivity varied between 2% and 48% depending on the RDT kit used. 6 The RDT kit which we used for this patient targets histidine-rich protein 2, specific to Plasmodium falciparum, and aldolase, a panmalarial antigen.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Plasmodium knowlesi Infection with Rhabdomyolysis in a Japanese Traveler to Palawan, the Philippines

Takaya

Kutsuna

Suzuki

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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Skeletal muscle is known to be damaged by falciparum malaria via sequestration of infected erythrocytes. We present a case of rhabdomyolysis caused by infection. The patient had fever, myalgia, and muscle weakness 5 days after returning to Japan from Palawan, the Philippines. Blood test revealed thrombocytopenia and an elevated creatine kinase level. Although rhabdomyolysis resolved with fluid therapy, fever of 24-hour cycle continued and thrombocytopenia intensified. On day 7 of illness, Giemsa-stained thin blood smear revealed malaria parasites, with a parasite count of 2,380/μL, which were morphologically indistinguishable between and . Rapid diagnostic test showed a negative result. The pathogen was later confirmed to be by nested polymerase chain reaction (PCR). The patient was successfully treated with artemether/lumefantrine. This case suggests that knowlesi malaria might be able to cause skeletal muscle damage.

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A Systematic Review: Performance of Rapid Diagnostic Tests for the Detection of Plasmodium knowlesi, Plasmodium malariae, and Plasmodium ovale Monoinfections in Human Blood

Abstract: This work summarizes the available data on the performance of rapid diagnostic tests (RDTs) for the detection of monoinfections due to Plasmodium species P. knowlesi, P. malariae, and P. ovale and indicates low performance of RDTs to detect these infections.

Cited by 55 publications

References 63 publications

High value of rapid diagnostic tests to diagnose malaria within children: A systematic review and meta-analysis

High value of rapid diagnostic tests to diagnose malaria within children: A systematic review and meta-analysis

Severity and mortality of severe Plasmodium ovale infection: A systematic review and meta-analysis

Case Report: Plasmodium knowlesi Infection with Rhabdomyolysis in a Japanese Traveler to Palawan, the Philippines

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