A target analogue imprinted polymer for the recognition of antiplatelet active ingredients in Radix Salviae Miltiorrhizae by LC/MS/MS

Huang, Meixia; Pang, Wensheng; Zhang, Jing; Lin, Siding; Hu, Juan

doi:10.1016/j.jpba.2011.09.010

Cited by 19 publications

(11 citation statements)

References 22 publications

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“…To date, molecularly imprinted materials as novel sorbent with predetermined selectivity have been used in a number of applications. Most of the studies mainly focus on the template molecule itself, the chiral isomer of the template, or the congener compounds different in several groups from the template [ 17 , 40 – 43 ], whereas using MIP to extract different types of compounds with similar bioactivities to the template from herbs [ 16 , 17 , 40 ], especially from the compound TCM preparation has rarely been reported. This research is the first attempt to use a molecular imprinted polymer with an active influenza virus neuraminidase inhibitor oseltamivir to simulate the receptor in recognizing different inhibitors according to their bioactivities.…”

Section: Discussionmentioning

confidence: 99%

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A Non-Biological Method for Screening Active Components against Influenza Virus from Traditional Chinese Medicine by Coupling a LC Column with Oseltamivir Molecularly Imprinted Polymers

Yang

Liu

et al. 2013

PLoS ONE

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To develop a non-biological method for screening active components against influenza virus from traditional Chinese medicine (TCM) extraction, a liquid chromatography (LC) column prepared with oseltamivir molecularly imprinted polymer (OSMIP) was employed with LC-mass spectrometry (LC-MS). From chloroform extracts of compound TCM liquid preparation, we observed an affinitive component m/z 249, which was identified to be matrine following analysis of phytochemical literatures, OSMIP-LC column on-line of control compounds and MS/MS off-line. The results showed that matrine had similar bioactivities with OS against avian influenza virus H9N2 in vitro for both alleviating cytopathic effect and hemagglutination inhibition and that the stereostructures of these two compounds are similar while their two-dimensional structures were different. In addition, our results suggested that the bioactivities of those affinitive compounds were correlated with their chromatographic behaviors, in which less difference of the chromatographic behaviors might have more similar bioactivities. This indicates that matrine is a potential candidate drug to prevent or cure influenza for human or animal. In conclusion, the present study showed that molecularly imprinted polymers can be used as a non-biological method for screening active components against influenza virus from TCM.

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Section: Discussionmentioning

confidence: 99%

“…These affinitive components would have the similar bioactivity to the template from a structure-activity relationship (SAR) point of view. MIPs have now been used for screening analogues with similar bioactivities to search for new drug candidates from plant extracts [ 16 , 17 ] or combinatorial chemistry libraries [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

A Non-Biological Method for Screening Active Components against Influenza Virus from Traditional Chinese Medicine by Coupling a LC Column with Oseltamivir Molecularly Imprinted Polymers

Yang

Liu

et al. 2013

PLoS ONE

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“…These affinitive compounds would have similar bioactivity to the template from a structure–activity relationship point of view. Nowadays, MIPs are used for screening analogues with similar bioactivities to search for new drug candidates from plant extracts [ 5 , 6 ] or combinatorial chemistry libraries [ 7 ]. The aim of our serial studies on MIP was to develop a nonbiological method for screening active components from traditional Chinese medicine (TCM) by coupling a liquid-chromatography (LC) column with MIPs [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Oseltamivir Molecularly Imprinted Polymer Silica Gel as Liquid Chromatography Stationary Phase

et al. 2018

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To improve the chromatographic performance of an oseltamivir (OS) molecularly imprinted polymer (MIP), silica gel coated with an MIP layer for OS (OSMIP@silica gel) was prepared by the surface molecular imprinting technology on the supporter of porous silica gel microspheres. A nonimprinted polymer with the silica gel (NIP@silica gel) was also prepared for comparison. The obtained particles were characterized through FT–IR, scanning electron microscopy, specific surface area analysis, and porosity measurements. The results indicated that the polymer was successfully synthesized and revealed the structural differences between imprinted and nonimprinted polymers. The results of static adsorption experiments showed that adsorption quantity of the OSMIP@silica gel for OS was higher than that for NIP@silica gel, and the OSMIP@silica gel had two kinds of affinity sites for OS but the NIP@silica gel had one. The chromatographic performance of the OSMIP@silica gel column had significant improvement. The imprinting factor of the OSMIP@silica gel column for OS was 1.64. Furthermore, the OSMIP@silica gel column showed good affinity and selectivity for template OS and another neuraminidase inhibitor, peramivir, but not for quinocetone. These results indicated that the prepared OSMIP could be used to simulate the activity center of neuraminidase, and the OSMIP@silica gel column could be also employed in future studies to search for more active neuraminidase inhibitor analogues from traditional Chinese herbs.

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“…Such quercetin‐related compounds are not efficiently trapped by most of the previously developed Qu MIPs due to the high rigidity of their cross‐linking (Molinelli et al , ; Weiss et al , ; O'Mahony et al , ; Song et al , ; Yu et al , ; Hong and Chen, ). Research has specifically focussed on drug discovery, with particular attention to the capability of MIPs for recognising analogues of the original template molecules (Xie et al ., ,b; Zhu et al , ; Zhu and Xu, ; O'Connor et al , ; Huang et al , ). For example, Xie et al .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Quercetin‐imprinted Polymer Spherical Particles with Improved Ability to Capture Quercetin Analogues

Pardo

Josse

Mespouille

et al. 2017

Phytochemical Analysis

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A target analogue imprinted polymer for the recognition of antiplatelet active ingredients in Radix Salviae Miltiorrhizae by LC/MS/MS

Cited by 19 publications

References 22 publications

A Non-Biological Method for Screening Active Components against Influenza Virus from Traditional Chinese Medicine by Coupling a LC Column with Oseltamivir Molecularly Imprinted Polymers

A Non-Biological Method for Screening Active Components against Influenza Virus from Traditional Chinese Medicine by Coupling a LC Column with Oseltamivir Molecularly Imprinted Polymers

Preparation and Evaluation of Oseltamivir Molecularly Imprinted Polymer Silica Gel as Liquid Chromatography Stationary Phase

Synthesis of Quercetin‐imprinted Polymer Spherical Particles with Improved Ability to Capture Quercetin Analogues

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