A Ten-year Follow-up of a Case with Gastric Adenoma Accompanied with Gastritis Cystica Profunda Treated by Endoscopic Submucosal Dissection

Kim, Jung Hee; Jang, Sung Yeol; Hwang, Jeong Ah; Ha, Sung Hae; Choi, Won Gyu; Park, Ju Sang; Han, Eun Mee

doi:10.4166/kjg.2012.59.5.366

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…[ 7 ] Okada et al reported a negative stance towards surgical excision. [ 8 ] However, in certain cases, such as those with the possibility of malignant transformation during endoscopic surveillance, [ 9 ] cases leading to compromised quality of life due to gastrointestinal symptoms such as abdominal pain and nausea, and cases resistant to conservative treatment, surgical resection should be considered.…”

Section: Discussionmentioning

confidence: 99%

Gastritis cystica profunda in an unoperated stomach mimicking a pyloric submucosal tumor and causing anorexia: A case report and literature review

Shimizu,

Hara,

Muto

et al. 2024

Medicine

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Background: Gastritis cystica profunda (GCP), commonly observed in remnant gastric anastomosis, is associated with developing gastric cancer. Case: This case report describes a patient with GCP in a previously unoperated stomach that mimicked a pyloric submucosal tumor and caused anorexia, which is rare in clinical practice. Patient concerns: A 72-year-old woman presented with loss of appetite and weight. Diagnoses: Gastroscopy detected a 20 mm diameter submucosal tumor near the pylorus. Computed tomography and magnetic resonance imaging identified a cystic lesion, unlike a usual submucosal tumor in the stomach. The diagnosis was difficult, even with endoscopic ultrasound-guided fine-needle aspiration. Interventions: Surgery was performed for diagnosis and treatment. The lesion was resected using a submucosal dissection technique after an incision of the gastric wall during open laparotomy. Histopathological examination confirmed the diagnosis of GCP and revealed no dysplasia or cancer. Outcomes: Anorexia resolved after the surgery. Residual or recurrent lesions were not detected during follow-up examinations performed 1 year after surgery. Lessons: GCP occurring in a previously unoperated stomach as a macroscopic lesion like a submucosal tumor causing some symptoms is rare. GCP is associated with a risk of developing cancer. Therefore, careful evaluation and management during treatment are required.

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Section: Discussionmentioning

confidence: 99%

Gastritis cystica profunda in an unoperated stomach mimicking a pyloric submucosal tumor and causing anorexia: A case report and literature review

Shimizu,

Hara,

Muto

et al. 2024

Medicine

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“…To date, two cases of recurrence have been reported after surgical resection (33,39). Meanwhile, a 10-year follow-up of a case of GCP in an unoperated patient revealed low-grade dysplasia, and the sizes of both the GCP and the adenoma overlying had increased during the follow-up period (45).…”

Section: Discussionmentioning

confidence: 99%

Gastritis cystica profunda: a case report and literature review

Du¹,

Zhang²,

Ma³

et al. 2020

Ann Palliat Med

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Gastric cystica profunda (GCP) is a rare disease characterized by multiple cystic lesions in the mucosa and/or submucosal layer. Usually, GCP occurs in stomachs that have previously been operated on.If there is no postoperative pathological results, it is challenging to diagnose GCP based on nonspecific clinical symptoms and imaging findings. This report aimed to provide a comprehensive overview of all cases of GCP reported to date. A comprehensive literature search was conducted for all reported GCP cases between 1972 and 2014. The keywords searched included "gastritis cystica profunda", "submucosal cysts of the stomach", and "heterotopic submucosal gastric glands". One retrospective case from our group was also reported and compared with those from the existing literature. A total of 52 cases were found including 37 (71.2%) men and 15 (28.8%) women (M/F ratio =2.5). The mean age of the patients was 59.9 (range, 39-91) years old. Among the cases, 58.8% (n=30) of lesions were located in the gastric body, 25.5% (n=13) of lesions were located in the fundus, 19.6% (n=9) of lesions were located in the antrum, and 3.9% (n=2) of lesions were located in the cardia, while 1 case was in the prepyloric lesion and 1 case was at the anastomotic site. Of the patients, 52% (n=26) had previously received gastric surgery. The main manifestations of GCP included abdominal pain (n=14, 36.8%) and gastrointestinal bleeding (including hematemesis and melena, n=7, 18.4%). Only 4 of the 52 cases were diagnosed before surgery, and the rest were diagnosed through postoperative histopathologic examination. GCP is difficult to correctly diagnose preoperatively due to its relative rarity and lack of typical clinical symptoms. Histopathological examination should be used for correct diagnosis. Complete surgical removal of the GCP is widely considered as the best treatment option.

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“…Its malignant potential should be valued because GCP accompanied by gastric adenocarcinoma has been documented in several reports [2,3,5-8]. Ten-year follow-up of a case with GCP in an unoperated patient revealed low-grade dysplasia, and the sizes of both the GCP and the adenoma overlying it increased during the follow-up period [14]. …”

Section: Discussionmentioning

confidence: 99%

Gastritis cystica profunda recurrence after surgical resection: 2-year follow-up

et al. 2014

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BackgroundGastritis cystica profunda (GCP) is an uncommon disease characterized by multiple cystic gastric glands within the submucosa of the stomach.Case descriptionHere, we present a case of a 63-year-old man with intermittent epigastric discomfort in whom gastroscopy revealed multiple irregular elevated nodular lesions with smooth surfaces at the anterior of the antrum. Surgical resection of the nodular lesions was performed, and the diagnosis of gastritis cystica profunda (GCP) was confirmed by histological examination. Another elevated nodular lesion approximately 10 mm in diameter with an ulcer was found on the gastric side of the remnant stomach near the resection side from 6 to 24 months after the surgical resection. Endoscopic ultrasonography (EUS) and repeated biopsies of the new elevated lesion were performed. Homogeneous, anechoic masses originating from the submucosa without gastric adenocarcinoma in histological examination showed GCP recurrence may occur.ConclusionsWe report a case of GCP recurrence within 6 months after surgical resection. GCP should be considered in the differential diagnosis of elevated lesions in the stomach.

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A Ten-year Follow-up of a Case with Gastric Adenoma Accompanied with Gastritis Cystica Profunda Treated by Endoscopic Submucosal Dissection

Cited by 6 publications

References 7 publications

Gastritis cystica profunda in an unoperated stomach mimicking a pyloric submucosal tumor and causing anorexia: A case report and literature review

Gastritis cystica profunda in an unoperated stomach mimicking a pyloric submucosal tumor and causing anorexia: A case report and literature review

Gastritis cystica profunda: a case report and literature review

Gastritis cystica profunda recurrence after surgical resection: 2-year follow-up

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