A ten-year historic study of paranasal cavity endoscopy in patients with leprosy

Martins, Ana Cristina; Castro, Jair de Carvalho e; Moreira, João

doi:10.1016/s1808-8694(15)31265-9

Cited by 9 publications

(9 citation statements)

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“…In this case series, it was widely administered alone or, in moderate and severe cases, in combination with other antifungals, simultaneously or sequentially. Notably, in some cases, even after complete remission of the skin lesions, nasal lesions persisted, suggesting the maintenance of a perivascular infiltration process during the granulomatous phase of the disease, similar to what is observed in some granulomatous diseases, such as leprosy and leishmaniasis [34,35].…”

Section: Plos Neglected Tropical Diseasessupporting

confidence: 66%

“…and severe lesion intensity predominated. Although uncommon in sporotrichosis, there were cases of destruction/perforation of the nasal septum, a condition more frequent in other granulomatous diseases, such as leprosy, tuberculosis, leishmaniasis and syphilis [ 14 , 34 ]. Specifically, for case 28, the extent of nasal septum destruction caused a flattening of the nasal pyramid.…”

Section: Discussionmentioning

confidence: 99%

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Sporotrichosis in the nasal mucosa: A single-center retrospective study of 37 cases from 1998 to 2020

et al. 2023

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Background Sporotrichosis is a subcutaneous or implantation mycosis caused by some species of the genus Sporothrix. Rio de Janeiro state, Brazil, experiences hyperendemic levels of zoonotic sporotrichosis, with increasing cases of disseminated disease, especially in people living with HIV (PLHIV). Involvement of the nasal mucosa is rare and occurs isolated or in disseminated cases, with a delayed resolution. Methodology/Principal findings This study aimed to describe the epidemiological, clinical, and therapeutic profiles of 37 cases of sporotrichosis with involvement of the nasal mucosa treated at the ear, nose, and throat (ENT) outpatient clinic of the Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, from 1998 to 2020. Data were reviewed from the medical records and stored in a database. The Mann–Whitney test was used to compare the means of quantitative variables, and Pearson chi-square and Fisher’s exact tests were used to verify the association between qualitative variables (p<0.05). Most patients were males, students or retirees, with a median age of 38 years, residents in the municipality of Rio de Janeiro, and infected through zoonotic transmission. Disseminated sporotrichosis forms in patients with comorbidities (mostly PLHIV) were more common than the isolated involvement of the mucosa. The main characteristics of lesions in the nasal mucosa were the presence/elimination of crusts, involvement of various structures, mixed appearance, and severe intensity. Due to therapeutic difficulty, itraconazole was combined with amphotericin B and/or terbinafine in most cases. Of the 37 patients, 24 (64.9%) healed, with a median of 61 weeks of treatment, 9 lost follow-up, 2 were still treating and 2 died. Conclusions Immunosuppression was determinant to the outcome, with worse prognosis and lower probability of cure. Notably in this group, the systematization of the ENT examination for early identification of lesions is recommended to optimize the treatment and outcome of the disease.

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Section: Plos Neglected Tropical Diseasessupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Sporotrichosis in the nasal mucosa: A single-center retrospective study of 37 cases from 1998 to 2020

et al. 2023

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“…Lepra da nazal bölge en sık etkilenen yerler arasındadır (6) . Nazal mukoza, lepra hastalığında hastalığın giriş çıkış kapısı olarak kabul edilir (8,12) . Lepra mukozal devamlılık ve basillemi nedeniyle paranazal sinüsleri etkileyebilir.…”

Section: Discussionunclassified

“…Martins ve ark. 'nın (12) yaptığı çalışmada 173 lepralı olgu değerlendirilmiş. Tüm olgularda nazal lezyonlar gözlenmiş olup, bu olguların 52'si herhangi bir yakınma tanımlamamaktadır.…”

Section: Discussionunclassified

“…Martins ve ark. 'nın (12) çalışmasında sonuç olarak, leprada görülen nazal mukozal etkilenmenin her dönemde ortaya çıkabileceği, özellikle kurutlanma, ülserasyon, nazal lezyonu olan olgularda lepra açısından şüphelenilmesi gerektiği, erken tanı ve multidispliner tedavi lepranın stigmatalara ve sosyal dışlanmaya neden olan sekellerinin oluşmasını engellediği vurgulanmıştır.…”

Section: Discussionunclassified

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