A Ten Year Retrospective Study on Adult Tetanus at the Epidemic Disease (ED) Hospital, Mysore in Southern India: A Review of 512 Cases

Marulappa, Vamadeva Giriyapura; Manjunath, R; Babu, Nakul Mahesh; Maligegowda, Laxman

doi:10.7860/jcdr/2012/4137.2363

Cited by 23 publications

(35 citation statements)

References 8 publications

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“…With the establishment and development of critical care medicine in China, the mortality rate of tetanus in 2015 had decreased by approximately 93.54% compared with that in 1990 [1]. In our study, only 5 adults (5.26%) died from tetanus, which was basically the same as the mortality rate in developed countries and significantly lower than that in other developing countries [1,4,17]. Nonetheless, the small number of patients included in this study cannot well reflect the current situation of tetanus in China, and more clinical studies should be performed in the future.…”

Section: Biomed Research Internationalsupporting

confidence: 56%

“…It is necessary to further standardize treatment with TAT. Only 9 patients in our study received HTIG treatment, and the proportion was much lower than that in other countries [4,17,18]. Although it is believed that the use of human or equine antitoxins (TAT and HTIG) does not change the mortality rate of tetanus, HTIG has a longer half-life in the body and causes fewer adverse reactions [14].…”

Section: Biomed Research Internationalmentioning

confidence: 79%

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Multicenter Study of Tetanus Patients in Fujian Province of China: A Retrospective Review of 95 Cases

Wang

Shang

et al. 2020

BioMed Research International

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Background. Tetanus is a life-threatening disease in developing countries and is accompanied by a high mortality rate. Although China is the world’s largest developing country, there have been few clinical studies on tetanus in China. The purpose of this study was to investigate the epidemiology, incidence, and management of tetanus in Fujian Province and to understand the current treatment and prognosis of tetanus patients. Methods. This was a retrospective, multicenter observational study of patients who presented with a clinical diagnosis of tetanus at 5 general hospitals in Fujian from January 2008 to December 2018. Data were analyzed using a computer software system. Results. A total of 95 patients were recruited, including 6 newborns. The average age of the adult tetanus patients was 55.53±15.39 years old. None of the patients knew their previous history of tetanus immunization. The rate of having received human tetanus immunoglobulin (HTIG) was 9.47%. A total of 73 (76.84%) patients were cured, 17 (17.89%) patients had an unknown prognosis, and 5 (5.26%) patients died. Age, severity of illness, and complications all increased the total duration of hospitalization. Compared with endotracheal intubation, tracheotomy increased the length of stay in the ICU (Intensive Care Unit) but did not affect the total hospital length of stay for mechanical ventilation. Conclusions. With the promotion of nationwide immunization against tetanus and the development of critical care medicine, morbidity and mortality rates of tetanus in Fujian are low. It is important to increase awareness among local physicians and staff in charge of tetanus immunization programs and with regard to neonatal tetanus and drug-induced tetanus. The prevention and treatment of tetanus in developing countries should arouse widespread concern in society.

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Section: Biomed Research Internationalsupporting

confidence: 56%

Section: Biomed Research Internationalmentioning

confidence: 79%

Multicenter Study of Tetanus Patients in Fujian Province of China: A Retrospective Review of 95 Cases

Wang

Shang

et al. 2020

BioMed Research International

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“…Mostly patients acquired tetanus following trauma which was mainly due to working bare footed in the fields and road traffic accidents. 7,8 In present study overall mortality rate is 16.5% which is quite consistent with the observation reported by Younas at el (18%) and Kole et al (21.6%), whereas Anuradha and Marulappa et al had reported higher mortality rate, 37.78%, and 42.2% respectively. [7][8][9][10] The present study observed that overall mortality due to tetanus was much lower compared with other Indian studies due to timely and proper management.…”

Section: Discussionsupporting

confidence: 90%

Study of clinico-epidemiological factors and outcome of tetanus in a tertiary care hospital

et al. 2018

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Background: Tetanus is an acute neurological fatal disorder caused by anaerobic spore forming bacillus Clostridium tetani, which produced an exotoxin (Tetanospasmin) in a wound. Purpose of this study was to find out the clinico-epidemiological factors of tetanus and how we can modify or minimize the outcome of this disease.Methods: This prospective, observational study was conducted in isolation ward in department of general surgery, SMS hospital Jaipur (Rajasthan) from 1 March 2016 to October 2017. Two hundred patients with clinical diagnosis of tetanus, who were admitted in single unit of SMS hospital, recruited in this study. Patients with age less than 1 yr were excluded. After admission, patient’s detailed history and thorough clinical examination done. The day to day progress of the cases was followed till the time of their discharge from the hospital. Outcome variables were age, gender, geographical area, causes of tetanus and site of injury, precipitating factors, role of baclofen, morbidity, cured and mortality.Results: In this study, mean age of patients were 17 years and male to female ratio was 2.44:1. Most of patients were from rural backgrounds with rural to urban ratio of 6.14:1. Overall mortality in present study was 16.5%. The severity of disease directly related with mortality. The mortality for mild, moderate and severe tetanus was 0%, 1.9% and 68.1% respectively.Conclusions: Though tetanus is a vaccine preventable illness, its prevalence is high in our country. The incidence of tetanus can be reduced by: strengthening of primary immunization programme; proper wound management and giving prophylactic tetanus immune globulins along with tetanus vaccine.

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“…Tourniquet, whenever applied on the spot, should be released only in hospital settings and after starting antivenin 2. Features in favour of tetanus (mortality of 10–60%) include incubation period, symptomatology and isolation of organism in the background of incisions and cow dung application 3. This patient had a high possibility of developing gas gangrene as well.…”

Section: Descriptionmentioning

confidence: 95%

Traditional first aid in a case of snake bite: more harm than good

Yanamandra

Yanamandra²

2014

BMJ Case Reports

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A Ten Year Retrospective Study on Adult Tetanus at the Epidemic Disease (ED) Hospital, Mysore in Southern India: A Review of 512 Cases

Cited by 23 publications

References 8 publications

Multicenter Study of Tetanus Patients in Fujian Province of China: A Retrospective Review of 95 Cases

Multicenter Study of Tetanus Patients in Fujian Province of China: A Retrospective Review of 95 Cases

Study of clinico-epidemiological factors and outcome of tetanus in a tertiary care hospital

Traditional first aid in a case of snake bite: more harm than good

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