A Theoretical Model of the Role of Brain Stem Nuclei in Alcohol-Mediated Arrhythmogenesis in Older Adults

Masters, Joan A.; Stevenson, Joanne

doi:10.1177/1099800402239627

Cited by 4 publications

(5 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although we observed higher values in the breast cancer survivors for the other HRV frequency components studied (LF band and LF/HF ratio), the differences did not reach significant levels. This cardiovascular imbalance, reflected by a parasympathetic nervous system withdrawal and sympathetic nervous system increase, is generally considered arrhythmogenic (Masters & Stevenson, 2003), may have a complex origin, and has been associated with multiple factors, including the type of oncologic treatment, cancer-related symptoms during survivorship phase (e.g., pain, fatigue, anxiety, etc. ), and the presence of comorbidities.…”

Section: Discussionmentioning

confidence: 99%

Heart Rate Variability in Breast Cancer Survivors After the First Year of Treatments

Caro-Morán

Fernández-Lao

Galiano‐Castillo

et al. 2015

Biological Research For Nursing

View full text Add to dashboard Cite

The same aggressive treatments that have led to a reduction in the breast cancer may also have adverse effects on cardiac autonomic balance. The objective of this study was to compare heart rate variability (HRV) between breast cancer survivors in the first year posttreatment and healthy women, controlling for known confounders. This descriptive case-controlled study included 22 breast cancer survivors and 22 healthy age- and sex-matched controls. Short-term HRV was measured using an accepted methodology to assess the cardiac autonomic balance. One-way analysis of covariance results revealed that heart rate was significantly higher (F = 15.86, p < .001) and the standard deviation of normal-to-normal (NN) interval (F = 19.93, p = .001), square root of mean squared differences of successive NN intervals (F = 18.72, p = .001), HRV index (F = 5.44, p = .025), and high-frequency (F = 5.77, p = .03) values were significantly lower in the breast cancer survivors than in the matched controls. The principal finding of the presence of a cardiovascular imbalance in breast cancer survivors in comparison to healthy age-matched controls suggests that HRV study could be a clinically useful tool to detect cardiovascular disease in early-stage breast cancer survivors.

show abstract

Section: Discussionmentioning

confidence: 99%

Heart Rate Variability in Breast Cancer Survivors After the First Year of Treatments

Caro-Morán

Fernández-Lao

Galiano‐Castillo

et al. 2015

Biological Research For Nursing

View full text Add to dashboard Cite

show abstract

“…Meta‐analyses have shown that: (a) older drinkers are more vulnerable than are younger ones to negative sequelae of alcohol use, including deleterious effects on organ systems (e.g., gastritis, hypertension, cardiac dysrhythmia, cardiomopathy, stroke, osteoporosis, several cancers, and liver and renal disease); (b) mixing alcohol with prescription drugs or OTC drugs can potentiate, prolong, or inhibit drug responses; and (c) age‐related changes in decreased body water‐to‐muscle and fat ratio and reduced physiological tolerance for alcohol result in higher risks for auto crashes, falls, fires, and psychological problems such as acute confusion, dementia, depression, or suicide (Corrao, Bagnardi, Zambon, & Arico, 1999; Corrao, Bagnardi, Zambon, & LaVecchia, 2004; Waern, Spak, & Sundh, 2002). Evidence also has shown that even low volume of alcohol consumption has been linked with heart rate variability, cardiac arrhythmias, and potential risk of sudden cardiac death (Masters & Stevenson, 2003; Masters, Stevenson, & Schaal, 2004).…”

Section: Introductionmentioning

confidence: 99%

Predictors of Alcohol Misuse and Abuse in Older Women

Stevenson

Masters

2005

J of Nursing Scholarship

Self Cite

View full text Add to dashboard Cite

The "best predictor model" showed that older women who were at risk for alcohol misuse or abuse had T-ACE scores of 1 or higher, used two or more OTC drugs regularly, drank large amounts of coffee, used alcohol to fall asleep, and had less sleep latency. Because positive T-ACE scores have high sensitivity and specificity for alcohol abuse, scores of 1 or greater should be addressed in clinical settings, e.g., referrals for more definitive diagnoses and relevant treatment.

show abstract

“…A recently published theoretical model of the role of brainstem nuclei in alcohol-mediated arrhythmogenesis in older adults synthesizes findings describing the independent effects of alcohol and aging on selected neurotransmitter systems operational in autonomic control of the variability in heart rate. The authors theorized that the effects of alcohol on the autonomic nervous system might be observable at moderate levels of drinking (Masters and Stevenson 2003). The purpose of the study reported here was to assess the association between moderate drinking and autonomic tone in healthy community-dwelling older women.…”

mentioning

confidence: 97%

“…The authors theorized that the effects of alcohol on the autonomic nervous system might be observable at moderate levels of drinking (Masters and Stevenson 2003). The purpose of the study reported here was to assess the association between moderate drinking and autonomic tone in healthy community-dwelling older women.…”

mentioning

confidence: 98%

The Association Between Moderate Drinking and Heart Rate Variability in Healthy Community-Dwelling Older Women

Masters

Stevenson

Schaal

2004

Biological Research For Nursing

Self Cite

View full text Add to dashboard Cite

The relationships among moderate alcohol use, autonomic tone, and arrhythmogenesis in older adults have not been adequately studied. Knowledge about these relationships is of increasing importance in light of population aging and recent epidemiological findings that associate moderate alcohol use with decreased rates of coronary artery disease. The purpose of this study was to assess the association between moderate drinking and autonomic tone in older women. Fifty-two Caucasian female participants (age 69 +/- 5.2) were enrolled in the study. Autonomic tone was estimated by time-domain and frequency-domain measures of heart rate variability. Multivariate analysis revealed that alcohol consumption rate in the sample accounted for approximately one third of the 24-h variability in the SDNN and the SDANN, measures of variability cycle lengths of 24-h and more than 5-min, respectively. Significant contributions of alcohol consumption rate to the shorter-term time-domain measures rMSSD and ASDNN, all frequency-domain measures, and HR were not confirmed. However, repeated measures ANOVA revealed that, between the hours of 0000 and 0600, women who drank approximately 0.5 to 3 standard drinks per day had significantly lower [log] HF and [log] LF power compared to abstainers and a tendency toward sympathetic predominance during the evening and nighttime hours. The authors discuss the implications of these findings.

show abstract

A Theoretical Model of the Role of Brain Stem Nuclei in Alcohol-Mediated Arrhythmogenesis in Older Adults

Cited by 4 publications

References 97 publications

Heart Rate Variability in Breast Cancer Survivors After the First Year of Treatments

Heart Rate Variability in Breast Cancer Survivors After the First Year of Treatments

Predictors of Alcohol Misuse and Abuse in Older Women

The Association Between Moderate Drinking and Heart Rate Variability in Healthy Community-Dwelling Older Women

Contact Info

Product

Resources

About