A theranostic nrGO@MSN-ION nanocarrier developed to enhance the combination effect of sonodynamic therapy and ultrasound hyperthermia for treating tumor

Chen, Yu Wei; Liu, Tse Ying; Chang, Po Hsueh; Hsu, Po Hung; Liu, Hao Li; Lin, Hong‐Cheu; Chen, San Yuan

doi:10.1039/c5nr07782f

Cited by 92 publications

(52 citation statements)

References 35 publications

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“…which limits its diffusion distance thereby limiting therapeutic efficacy [32]. This would present a particular challenge where the actual nanoparticle itself is the sensitizer or where the sensitizer is covalently attached to the nanoparticle where stimulus-generated ROS would be expected to diffuse away from the actual sensitizer in order to elicit a cytotoxic effect [10,11,32,33]. Such a limitation would also be exacerbated in less vascularized tumours and those comprising a high proportion of stroma, both of which are negative prognostic markers in cancer as a result of limited diffusion and dispersion of therapeutics throughout the tumour tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Although others have reported the use of nanoparticle-based platforms in PDT and more recently in SDT [10,11,32,33] none have described a single multifunctional, biodegradable nanoparticle-based preparation with diagnostic capabilities, composed of clinically-approved reagents for use in both SDT and PDT and enabling the slow release of sensitizer that could enhance dispersion of that sensitizer at the target site. Use of the PLGA 23 nanoparticle platform enables the use of therapeutic doses of an otherwise insoluble porphyrin and provides a degree of tumour specificity that is superior to that obtained with clinically approved, porphyrin-based sensitisers.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to aiding the preferential accumulation of sensitiser in target lesions, nanoparticles can also be exploited to deliver multiple functionalities and this approach has been used to incorporate diagnostic as well as therapeutic capabilities in a single formulation. In another recent study, Chen et al described the use mesoporous silica grown on reduced graphene nanosheet that was capped with rose bengal-conjugated to iron-oxide nanoparticles and demonstrated its use to simultaneously generate cytotoxic ROS and induce hyperthermia in an acoustic field [11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapy

et al. 2017

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We describe a biocompatible and biodegradable nanoparticle-based platform for use in sonodynamic and photodynamic therapeutic approaches for the treatment of cancer. The non-toxic nanoparticles produce cytotoxic reactive oxygen species when exposed to ultrasound and/or light at levels that have no impact on tissues. The system is unique in that it is accumulated by tumours within six hours and has the ability to release its sensitising capability while retaining its imaging capability within a therapeutic time frame. The former could enhance dispersion and sensitising capabilities in less permeable tumour tissues and the latter permits the design of therapeutic approaches that minimize collateral damage to normal tissues.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapy

et al. 2017

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“…Reduced graphene oxide nanosheet (nrGO) was employed as the substrate, which was further coated by a mesoporous silica layer (MSN). Sonosensitizer Rose Bengal (RB)‐PEG‐conjugated iron oxide (IONs) were finally capped onto the surface of MSN layer to form a composite nrGO@MSN‐ION‐PEG‐RB nano‐sensitizer ( Figure a) . Graphene oxide nanosheet (nrGO) was chosen because of its high heat‐conducting capability, which could be used to increase the local tissue temperature upon US irradiation.…”

Section: Inorganic Micro/nanoparticle‐augmented Sonosensitizermentioning

confidence: 99%

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

2016

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The fast development of photoactivation for cancer treatment provides an efficient photo-therapeutic strategy for cancer treatment, but traditional photodynamic or photothermal therapy suffers from the critical issue of low in vivo penetration depth of tissues. As a non-invasive therapeutic modality, sonodynamic therapy (SDT) can break the depth barrier of photoactivation because ultrasound has an intrinsically high tissue-penetration performance. Micro/nanoparticles can efficiently augment the SDT efficiency based on nanobiotechnology. The state-of-art of the representative achievements on micro/nanoparticle-enhanced SDT is summarized, and specific functions of micro/nanoparticles for SDT are discussed, from the different viewpoints of ultrasound medicine, material science and nanobiotechnology. Emphasis is put on the relationship of structure/composition-SDT performance of micro/nanoparticle-based sonosensitizers. Three types of micro/nanoparticle-augmented SDT are discussed, including organic and inorganic sonosensitizers and micro/nanoparticle-based but sonosensitizer-free strategies to enhance the SDT outcome. SDT-based synergistic cancer therapy augmented by micro/nanoparticles and their biosafety are also included. Some urgent critical issues and potential developments of micro/nanoparticle-augmented SDT for efficient cancer treatment are addressed. It is highly expected that micro/nanoparticle-augmented SDT will be quickly developed as a new and efficient therapeutic modality which will find practical applications in cancer treatment. At the same time, fundamental disciplines regarding materials science, chemistry, medicine and nanotechnology will be advanced.

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“…US‐triggered SDT has been extensively explored for cancer therapy, which depends on the reactive oxygen species (ROS) production but the tumor hypoxia unfortunately induces the low ROS‐production efficacy . To solve this critical issue, an oxygen‐self‐produced nanoplatform was constructed for relieving the tumor hypoxia and enhancing the SDT‐therapeutic efficacy .…”

Section: Oxygen (O2)‐generating Ggnsmentioning

confidence: 99%

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

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The fast advances of theranostic nanomedicine enable the rational design and construction of diverse functional nanoplatforms for versatile biomedical applications, among which gas-generating nanoplatforms (GGNs) have emerged very recently as unique theranostic nanoplatforms for broad gas therapies. Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease-environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H ), hydrogen sulfide (H S) and sulfur dioxide (SO ), and other gases such as carbon dioxide (CO ), dl-menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(d,l-lactic-co-glycolic acid), micelles, silica/mesoporous silica, organosilica, MnO , graphene, Bi Se , upconversion nanoparticles, CaCO , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.

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A theranostic nrGO@MSN-ION nanocarrier developed to enhance the combination effect of sonodynamic therapy and ultrasound hyperthermia for treating tumor

Cited by 92 publications

References 35 publications

A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapy

A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapy

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

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