A Therapeutic and Diagnostic Dilemma: Granular Cell Tumor of the Breast

Pergel, Ahmet; Yücel, Ahmet Fikret; Karaca, Ahmet Serdar; Aydın, İbrahim; Şahin, Dursun Ali; Demirbag, Nilgun

doi:10.1155/2011/972168

Cited by 24 publications

(38 citation statements)

References 9 publications

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“…Despite the success of screening, however, review of published cases suggests that until recently, most cases (70%) were found by palpation (Brown et al, 2011) as in our patient. Clinically GCT can resemble cancer due to firm consistency, nipple and/or skin retraction (Lack et al, 1980;Pergel et al, 2011). These features can be attributed to stromal desmoplasia that was observed in our case as well.…”

Section: Discussionsupporting

confidence: 73%

Granular Cell Tumour of the Breast Cancer: Challenging Clinical and Radiological Mimic of Cancer

Āboliņš¹,

Štrumfa²,

Vanags³

et al. 2012

Acta Chirurgica Latviensis

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SummaryGranular cell tumours (GCT) are rare soft tissue neoplasms of unclear histogenesis affecting almost any organ or tissues. Approximately 5% of GCT cases are located in the breast. Although granular cell tumour is benign in most instances, it can mimic breast cancer by radiological and clinical traits. Increased awareness of GCT is necessary to avoid misinterpretation as cancer and subsequent overtreatment

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Section: Discussionsupporting

confidence: 73%

Granular Cell Tumour of the Breast Cancer: Challenging Clinical and Radiological Mimic of Cancer

Āboliņš¹,

Štrumfa²,

Vanags³

et al. 2012

Acta Chirurgica Latviensis

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“…GCTs account for an incidence of 0.5% among soft tissue tumors (3)(4)(5)(6). It may occur throughout the body, usually in the head and neck, skin or subcutaneous tissues of the trunk and upper extremities.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, Costa Almeida et al (7) published a case report of GCT on the upper limb and reviewed 21 patients with this GCT localization from the literature. When occurring in the breast, as it occurs in 5-8% of all cases of GCT, they present mostly as painless rounded nodules (4,6). GCT of the breast may mimic breast cancer both clinically and radiologically (8-10).…”

Section: Discussionmentioning

confidence: 99%

“…GCTs were considered to arise from Schwann cells, histiocytes, fibroblasts, myocytes or intestinal mesenchymal cells. Nowadays, the accepted theory claims nerve sheath origin of the tumour (3,4). These tumors may occur throughout the body, usually in the head and neck, skin or subcutaneous tissues of the trunk and upper extremities, breasts and female genital region.…”

Section: Introductionmentioning

confidence: 99%

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Granular cell tumor in axillary region: A rare entity

2018

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Abstract. A granular cell tumor (GCT), is a rare soft tissue tumor which may occur throughout the body, usually in the head and neck, skin or subcutaneous tissues of the trunk and upper extremities, and female genital region. A total of 5-8% of all cases of GCTs occur in the breast. GCT of the breast may mimic breast cancer both clinically and radiologically. GCTs are usually benign and solitary; however, approximately 2% occur as malignant tumors. Benign GCTs are treated with wide local excision and are associated with a good prognosis. The current case report presents findings in a patient with a benign form of GCT in a rare location, specifically in the axillary region.

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“…Some GCTs of the breast have been documented to be coexisting with an ipsilateral infiltrating ductal carcinoma8–10 and also as a lesion occurring in mastectomy scars 11. The most frequent location is the upper-middle and medial quadrant, and the most frequent positive receptors are S-protein, periodic acid–Schiff (PAS) and diastase 9,10. It is more common in middle aged, premenopausal, black women and is extremely rare in male patients 3…”

Section: Introductionmentioning

confidence: 99%

Granular cell tumor in breast: a case report

Lara¹,

Herrera²,

Cardoso³

et al. 2017

BCTT

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Granular cell tumor (GCT) is a rare neoplasm of the soft tissues, and <1% of all GCTs are malignant. It usually appears in the tongue and sometimes may affect the female breast. Initially, GCT was considered to be a myogenic lesion affecting female breast (myoblastoma). Actually, it is assumed as a tumor originating from perineural or putative Schwann cells of peripheral nerves or their precursors that grows in the lobular breast tissue, due to the immunohistochemical features. Here, we review the importance of differentiating between this tumor and malignant breast carcinoma. Mammographically, by ultrasound scan and clinically, this case appears to be a malignant tumor of the breast, but with a correct and precise diagnosis including histopathologic examination and immunohistochemical studies, it was correctly identified as a GCT.Case detailsWe present a case of a 52-year-old premenopausal woman. This report is of interest because of patient’s familial oncologic history and personal history of gynecologic cancer. This rare tumor of the breast and the special way to approach the tumor by local anesthesia makes it interesting to communicate.ConclusionThis is a case of interest because GCT located in the breast is very unusual and knowledge of GCT is required for the differential diagnosis with breast cancer.

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A Therapeutic and Diagnostic Dilemma: Granular Cell Tumor of the Breast

Cited by 24 publications

References 9 publications

Granular Cell Tumour of the Breast Cancer: Challenging Clinical and Radiological Mimic of Cancer

Granular Cell Tumour of the Breast Cancer: Challenging Clinical and Radiological Mimic of Cancer

Granular cell tumor in axillary region: A rare entity

Granular cell tumor in breast: a case report

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