A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices

Vadivel, Arul; Kartha, Reena V.; Rajadas, Jayakumar

doi:10.1016/j.lfs.2006.09.018

Cited by 73 publications

(40 citation statements)

References 45 publications

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“…Superoxide dismutase was increased 80% while catalase was increased 56% [52, 53]. GHK reduced gastric mucosal damage by 75% against lipid peroxidation by oxygen-derived free radicals induced by acute intragastric administration of ethanol [54].…”

Section: Discussionmentioning

confidence: 99%

GHK and DNA: Resetting the Human Genome to Health

Pickart¹,

Vasquez-Soltero²,

Margolina³

2014

BioMed Research International

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During human aging there is an increase in the activity of inflammatory, cancer promoting, and tissue destructive genes plus a decrease in the activity of regenerative and reparative genes. The human blood tripeptide GHK possesses many positive effects but declines with age. It improves wound healing and tissue regeneration (skin, hair follicles, stomach and intestinal linings, and boney tissue), increases collagen and glycosaminoglycans, stimulates synthesis of decorin, increases angiogenesis, and nerve outgrowth, possesses antioxidant and anti-inflammatory effects, and increases cellular stemness and the secretion of trophic factors by mesenchymal stem cells. Recently, GHK has been found to reset genes of diseased cells from patients with cancer or COPD to a more healthy state. Cancer cells reset their programmed cell death system while COPD patients' cells shut down tissue destructive genes and stimulate repair and remodeling activities. In this paper, we discuss GHK's effect on genes that suppress fibrinogen synthesis, the insulin/insulin-like system, and cancer growth plus activation of genes that increase the ubiquitin-proteasome system, DNA repair, antioxidant systems, and healing by the TGF beta superfamily. A variety of methods and dosages to effectively use GHK to reset genes to a healthier state are also discussed.

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Section: Discussionmentioning

confidence: 99%

GHK and DNA: Resetting the Human Genome to Health

Pickart¹,

Vasquez-Soltero²,

Margolina³

2014

BioMed Research International

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“…skin, bone, cartilage, tendon and ligaments). It represents 25% of the total protein body content [80,102,160,161], providing strength and integrity to tissue matrices [162]. In addition, collagen can also interact with cells and help essential cell signaling that will regulate cell anchorage, migration, proliferation, differentiation and survival [101,120,162].…”

Section: Cellulose and Its Derivativesmentioning

confidence: 99%

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

et al. 2013

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a b s t r a c tDiabetic foot ulcers (DFUs) are a chronic, non-healing complication of diabetes that lead to high hospital costs and, in extreme cases, to amputation. Diabetic neuropathy, peripheral vascular disease, abnormal cellular and cytokine/chemokine activity are among the main factors that hinder diabetic wound repair. DFUs represent a current and important challenge in the development of novel and efficient wound dressings. In general, an ideal wound dressing should provide a moist wound environment, offer protection from secondary infections, remove wound exudate and promote tissue regeneration. However, no existing dressing fulfills all the requirements associated with DFU treatment and the choice of the correct dressing depends on the wound type and stage, injury extension, patient condition and the tissues involved. Currently, there are different types of commercially available wound dressings that can be used for DFU treatment which differ on their application modes, materials, shape and on the methods employed for production. Dressing materials can include natural, modified and synthetic polymers, as well as their mixtures or combinations, processed in the form of films, foams, hydrocolloids and hydrogels. Moreover, wound dressings may be employed as medicated systems, through the delivery of healing enhancers and therapeutic substances (drugs, growth factors, peptides, stem cells and/or other bioactive substances). This work reviews the state of the art and the most recent advances in the development of wound dressings for DFU treatment. Special emphasis is given to systems employing new polymeric biomaterials, and to the latest and innovative therapeutic strategies and delivery approaches.

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“…In one example, curcuminincorporated collagen matrices (CICM) were developed to improve full-thickness wound healing in rats [51]. The same collagen scaffold was used to release Glycyl-histidyl-lysine (GHK), a matrikine with numerous healing properties such as angiogenesis and growth factor activation [52, 53]. Interestingly, the group has also investigated the sustained release of both reactive oxygen species (ROS) [54], and antioxidants [55] into the wound bed.…”

Section: Scaffoldsmentioning

confidence: 99%

Drug Delivery Systems for Wound Healing

Johnson¹,

Wang²

2015

CPB

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Protein, gene, and small molecule therapies hold great potential for facilitating comprehensive tissue repair and regeneration. However, their clinical value will rely on effective delivery systems which maximize their therapeutic benefit. Significant advances have been made in recent years towards biomaterial delivery systems to satisfy this clinical need. Here we summarize the most outstanding advances in drug delivery technology for cutaneous wound healing.

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A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices

Cited by 73 publications

References 45 publications

GHK and DNA: Resetting the Human Genome to Health

GHK and DNA: Resetting the Human Genome to Health

Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review

Drug Delivery Systems for Wound Healing

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