A Therapeutic Wireless Capsule for Treatment of Gastrointestinal Haemorrhage by Balloon Tamponade Effect

Leung, Billy C.S.; Poon, Chi‐Sang; Zhang, Ruikai; Zheng, Yali; Chan, Cecilia Ka Wing; Chiu, Philip Wai Yan; Lau, James Y.; Sung, Joseph J.Y.

doi:10.1109/tbme.2016.2591060

Cited by 29 publications

(31 citation statements)

References 24 publications

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“…Firstly, an inflatable device was developed for the closed loop detection and treatment of GI hemorrhage by the balloon tamponade effect ( Figure a) . A lightweight automatic bleeding detection algorithm quantifies the number of blood‐colored pixels from an endoscope image to determine the extent of the bleeding.…”

Section: Ingestible Robot For Surgical Interventionmentioning

confidence: 99%

Section: Ingestible Robot For Surgical Interventionmentioning

confidence: 99%

“…Robotic strategies incorporating GI drug injection and drug‐loaded microrobots have been explored to enhance the efficacy of drug delivery . Also, various robotic structures have been prototyped to capacitate minimally invasive surgery in the gut . In addition, several ingestible robot prototypes utilized the narrow passage through the pylorus for gastric retention, enabling prolonged drug delivery or gut health monitoring …”

Section: Introductionmentioning

confidence: 99%

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Robotics in the Gut

Min

Yang

et al. 2019

Advanced Therapeutics

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Since the advent of ingestible temperature sensors and capsule endoscopes, rapid advances in electronics, robotics, nanotechnology, and material sciences have opened the door for the development of novel medical ingestible robots. The untethered robots provide direct, non-invasive access to the entire gastrointestinal (GI) tract. Furthermore, the tissues, gases, and fluids of the gastrointestinal lumen contain a multitude of biomarkers indicative of gut diseases and health. Ingestible medical robots equipped with advanced imaging and sensing techniques can enable the diagnosis and monitoring of diseases, while providing a better pathophysiological understanding of gastrointestinal disorders. In addition, various robotic actuation mechanisms in the macro-and microscale can realize enhanced drug delivery and surgical interventions for the treatment of diseases. In this paper, an overview of recent advances in ingestible robots toward imaging, sensing, drug delivery, and surgical applications in the GI tract is provided. Key challenges and strategies for the development of novel ingestible robots and future directions of ingestible robots toward precision medicine are also discussed.

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Section: Ingestible Robot For Surgical Interventionmentioning

confidence: 99%

Section: Ingestible Robot For Surgical Interventionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Robotics in the Gut

Min

Yang

et al. 2019

Advanced Therapeutics

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“…In vitro experiments showed that SonoCAIT achieved enhancement of drug uptake. been proposed by the group of Leung et al [35]. The capsule consists of three segments linked with flexible joints.…”

Section: Sonocaitmentioning

confidence: 99%

The future of capsule endoscopy in clinical practice: from diagnostic to therapeutic experimental prototype capsules

Vasilakakis

Koulaouzidis

Marlicz

et al. 2020

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Capsule endoscopy (CE) is indicated as a first-line clinical examination for the detection of small-bowel pathology, and there is an ever-growing drive for it to become a method for the screening of the entire gastrointestinal tract (GI). Although CE's main function is diagnosis, the research for therapeutic capabilities has intensified to make therapeutic capsule endoscopy (TCE) a target within reach. This manuscript presents the research evolution of CE and TCE through the last 5 years and describes notable problems, as well as clinical and technological challenges to overcome. This review also reports the state-of-the-art of capsule devices with a focus on CE research prototypes promising an enhanced diagnostic yield (DY) and treatment. Lastly, this article provides an overview of the research progress made in software for enhancing DY by increasing the accuracy of abnormality detection and lesion localisation. The future of capsule endoscopy-experimental devices for diagnosis and therapy Gastroenterology Review

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“…In addition to capturing images, a wireless capsule controlled in the body could have a wide range of medical applications such as drug delivery or sample collection from part of the GI tract for testing. Leung et al [2] proposed an inflatable capsule that has a balloon structure to stop the bleeding in the small intestine. For an active WCE, the velocity of a capsule moving within the body is important to allow clear and sufficient pictures.…”

Section: Introductionmentioning

confidence: 99%

A Locomotion Control Platform With Dynamic Electromagnetic Field for Active Capsule Endoscopy

Alsunaydih

Redouté

Yuce

2018

IEEE J. Transl. Eng. Health Med.

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Conventional radiological and endoscopic techniques utilizing long tubes were ineffective in visualizing the small bowel mucosa until the development of wireless capsule endoscopy (WCE). WCE is a revolutionary endoscopic technology that can diagnose the complete gastrointestinal tract. However, the existing capsule technologies are passive, and thus they cannot be navigated to or held in a specific location. The design of an active capsule will present the opportunity to move and stop a device at any targeted locations leading to numerous medical applications such as drug delivery or collecting tissue samples for examinations in the laboratory. This paper implements a new locomotion methodology for WCE systems using an electromagnetic platform. The platform produces a dynamic electromagnetic field to control the motion of the capsule. The strength and the direction of the electromagnetic field that is generated by the platform are continuously adjusted in order to maintain the equilibrium state during the capsule movement. We present the detailed design of the proposed platform with an experimental setup with polyvinyl chloride tubes and ex vivo to demonstrate the performance of the capsule motion.

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A Therapeutic Wireless Capsule for Treatment of Gastrointestinal Haemorrhage by Balloon Tamponade Effect

Abstract: To our best knowledge, this is the first study that demonstrated the potential to treat GI haemorrhage by an inflatable WCE. The proposed capsule enables the development of a closed-loop system based on a body sensor network to provide early treatment of GI bleeding for p-medicine.

Cited by 29 publications

References 24 publications

Robotics in the Gut

Robotics in the Gut

The future of capsule endoscopy in clinical practice: from diagnostic to therapeutic experimental prototype capsules

A Locomotion Control Platform With Dynamic Electromagnetic Field for Active Capsule Endoscopy

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