A Thermoresponsive Hydrogel Based on Telechelic PEG End‐Capped with Hydrophobic Dipeptides

Hamley, Ian W.; Cheng, Ge; Castelletto, Valeria

doi:10.1002/mabi.201100022

Cited by 47 publications

(73 citation statements)

References 62 publications

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“…Linear architectures of peptide‐PEG conjugates have been reported in other studies . However, few systems were able to show hydrogel formation through supramolecular interactions.…”

Section: Self‐assembling Hydrogels Of Peptide–polymer Conjugatesmentioning

confidence: 81%

Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

Radvar

Azevedo

2018

Macromolecular Bioscience

127

107

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Peptides and polymers are the "elite" building blocks in hydrogel fabrication where the typical approach consists of coupling specific peptide sequences (cell adhesive and/or enzymatically cleavable) to polymer chains aiming to obtain controlled cell responses (adhesion, migration, differentiation). However, the use of polymers and peptides as structural components for fabricating supramolecular hydrogels is less well established. Here, the literature on the design of peptide/polymer systems for self-assembly into hybrid hydrogels, as either peptide-polymer conjugates or combining both components individually, is reviewed. The properties (stiffness, mesh structure, responsiveness, and biocompatibility) of the hydrogels are then discussed from the viewpoint of their potential biomedical applications.

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“…Linear architectures of peptide‐PEG conjugates have been reported in other studies . However, few systems were able to show hydrogel formation through supramolecular interactions.…”

Section: Self‐assembling Hydrogels Of Peptide–polymer Conjugatesmentioning

confidence: 81%

Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

Radvar

Azevedo

2018

Macromolecular Bioscience

127

107

View full text Add to dashboard Cite

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“…For example, thermoresponsive hydrogels constituted of a telechelic PEG end-capped with hydrophobic dipeptides (i.e., phenylalanine-phenylalanine (Phe-Phe) or tyrosine-tyrosine (Tyr-Tyr) were proposed to be used in responsive delivery or encapsulation for biomedical applications [103]. In another study, PEG was replaced with an amphiphilic ABA-block copolymer (Pluronic F127) consisting in PEG end blocks and a poly(propylene oxide) (PPO) center block, which was able to self-assemble into micelles with a water-incompatible compartment that was segregated from the aqueous exterior by the PEG shell.…”

Section: Crosslinked Hydrogels and Scaffolds For Tissue Engineeringmentioning

confidence: 99%

Hybrid Block Copolymers Constituted by Peptides and Synthetic Polymers: An Overview of Synthetic Approaches, Supramolecular Behavior and Potential Applications

Morell

Puiggalı́

2013

Polymers

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Hybrid block copolymers based on peptides and synthetic polymers, displaying different types of topologies, offer new possibilities to integrate the properties and functions of biomacromolecules and synthetic polymers in a single hybrid material. This review provides a current status report of the field concerning peptide-synthetic polymer hybrids. The first section is focused on the different synthetic approaches that have been used within the last three years for the preparation of peptide-polymer hybrids having different topologies. In the last two sections, the attractive properties, displayed in solution or in the solid state, together with the potential applications of this type of macromolecules or supramolecular systems are highlighted.

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“…The temperature responsive hydrogels introduced in this section are mainly prepared based on the scaffolds of supramolecular assembled structure [28][29][30], hydrogel films [31] and hydrogel sphere [32,33]. Additionally, the temperature responsive hydrogels constructed employing the novel technics are also summarized [34][35][36].…”

Section: Responsive Hydrogelsmentioning

confidence: 99%

“…Typically, as the dynamic cross-link of CB [8]/viologen/naphthoxy, this hydrogel exhibited thermal reversibility. Additionally, the temperature responsive hydrogels based on hydrophobic interaction of dipeptides [40] and cyclic macromonomer crosslinking interaction [41] were also reported. Using a photo-crosslinkable benzophenone unit, Knoll and coworkers prepared the responsive hydrogel films by photo-cross-link method based on poly(N-isopropylacrylamide)(PNIPAM) copolymer [42].…”

Section: Responsive Hydrogelsmentioning

confidence: 99%

Temperature Responsive Hydrogels:Construction and Applications

Yin¹

2016

Polym Sci

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IntroductionAs a kind of smart materials, responsive hydrogels exhibit the rapidly responsive ability and sharp volume phase transitions according to the external stimuli from environment. Hydrogels demonstrate large-scale volumetric changes in response to small levels of stimuli. To the best of our knowledge, the most typical external stimuli factors related to responsive behaviors of smart hydrogels are pH [1][2][3][4][5], temperature [6][7][8], light [9][10][11] and multi-factors [12][13][14][15][16]. Additionally, the responsive hydrogels based on enzyme responsive [17,18], calcium responsive [19,20], glucose responsive [21,22], redox responsive [23,24], ionicstrength responsive [25,26], and chemical responsive [27] are also exhibited amazing responsive abilities. Among these insights, temperature responsive hydrogels are particularly important.This article gives an overview of the fundamentals of temperature responsive hydrogels. Some researches related to the construction methods, responsive mechanisms and applications of responsive hydrogels in the past few years are reviewed. Construction Method of Temperature Responsive HydrogelsThe temperature responsive hydrogels introduced in this section are mainly prepared based on the scaffolds of supramolecular assembled structure [28][29][30], hydrogel films [31] and hydrogel sphere [32,33]. Additionally, the temperature responsive hydrogels constructed employing the novel technics are also summarized [34][35][36]. Ritter and coworkers pioneered in construction of temperature responsive hydrogel using N-isopropylacrylamide as monomer [37]. As illustrated in Figure 1 based on the hostguest interaction between adamantyl group and cyclodextrin, the thermosensitive hydrogel 1 was prepared. Similarly, based on the host-guest interaction between D3-symmetric tris(spiroborate) cyclophane and [Ir(tpy) 2 ](PF 6 ) 3 complex, the assembled chain structure was obtained by Yamaguchi et al.[38]. Moreover, employing the host-guest interaction between cucurbit[8]uril and viologen/naphthoxy, a thermo-sensitive supramolecular polymer hydrogel 2 was prepared by Scherman and coworkers [39]. Typically, as the dynamic cross-link of CB[8]/viologen/naphthoxy, this hydrogel exhibited thermal reversibility. Additionally, the temperature responsive hydrogels based on hydrophobic interaction of dipeptides [40] and cyclic macromonomer crosslinking interaction [41] were also reported. Using a photo-crosslinkable benzophenone unit, Knoll and coworkers prepared the responsive hydrogel films by photo-cross-link method based on poly(N-isopropylacrylamide)(PNIPAM) copolymer [42]. To fabricate hydrogel nanoparticles with ultrafine nanosized hair, Yang's group developed a simple self-developed approach AbstractResponsive hydrogels have attracted researcher's special attentions. Up to now, a wide variety of responsive hydrogels are continuously constructed and the responsive mechanisms are deeply investigated. Typically, versatile responsive hydrogels with pH responsive, temperature responsive, ligh...

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A Thermoresponsive Hydrogel Based on Telechelic PEG End‐Capped with Hydrophobic Dipeptides

Cited by 47 publications

References 62 publications

Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications

Hybrid Block Copolymers Constituted by Peptides and Synthetic Polymers: An Overview of Synthetic Approaches, Supramolecular Behavior and Potential Applications

Temperature Responsive Hydrogels:Construction and Applications

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