A thiophene based pyrrolo [1, 2-a] quinoxaline fluorescent probe as a “turn-off” sensor for the selective nanomolar detection of sodium ion

Divya, Kumble; Savitha, D.P.; Krishna, Gopal; Dhanya, T.M.; Mohanan, P.V.

doi:10.1016/j.jphotochem.2022.114046

Cited by 9 publications

(5 citation statements)

References 36 publications

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“…In order to reveal the quenching mechanism, quenching experiments of the N-CDs@Eu-UiO-66-(COOH) 2 caused by HOCl were conducted at 293 K. Figure C shows that I 0 / I at 440 nm is linear with the concentrations of HOCl, suggesting that both static and dynamic quenching is possible. According to the SV equation, the quenching rate constant ( K q ) was 3.69 × 10 4 L·mol –1 ·s –1 , which was lower than the maximum collision quenching constant of 2.0 × 10 10 L·mol –1 ·s –1 in the dynamic quenching process, indicating that the quenching mechanism belongs to dynamic quenching. To verify the quenching mechanism, transient fluorescence spectra at 440 nm in the absence and presence of HOCl were measured.…”

Section: Resultsmentioning

confidence: 83%

Selective Determination of HOCl in Environmental Water Samples and Real-Time Detection of HOCl Levels in Live Cells via Ratio Fluorescence Imaging Based on Eu³⁺-Modified and Carbon Dot-Encapsulated Metal Organic Frameworks

Zhang,

Tong

2024

ACS Appl. Nano Mater.

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Hypochlorous acid (HOCl) is one kind of significant ROS and a typical environmental pollution, which is closely linked to our food chain and threatens human health. Hence, a dual-emission ratiometric fluorescent nanoprobe (N-CDs@Eu-UiO-66-(COOH)2) for sensitive and specific determination of HOCl was fabricated based on Eu3+-modified and carbon dot-encapsulated MOFs. The N-CDs were encapsulated into MOFs, which can greatly improve their photostability and resistance to photobleaching in aqueous solution. The N-CDs@UiO-66-(COOH)2 was modified by Eu3+ ions, which can emit the red characteristic fluorescence of Eu3+ ions via the antenna effect. HOCl can quench the fluorescence of N-CDs through oxidizing hydroxyl groups on its surface, while the characteristic fluorescence of Eu3+ remains unchanged. The ratiometric fluorescence nanoprobe of N-CDs@Eu-UiO-66-(COOH)2 was thus fabricated for detecting HOCl. The nanoprobe has high sensitivity and selectivity, and its LOD (3σ/K) can attain 15.0 nM. Moreover, the N-CDs@Eu-UiO-66-(COOH)2 nanoprobe can also be applied for real-time detection of HOCl levels in the live cells via ratio fluorescence imaging, which can serve as a noninvasive tool for sensitively detecting fluctuations of HOCl levels in the living cells. This work can provide a promising application in environmental monitoring and real-time monitoring HOCl levels in vivo.

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Section: Resultsmentioning

confidence: 83%

Selective Determination of HOCl in Environmental Water Samples and Real-Time Detection of HOCl Levels in Live Cells via Ratio Fluorescence Imaging Based on Eu³⁺-Modified and Carbon Dot-Encapsulated Metal Organic Frameworks

Zhang,

Tong

2024

ACS Appl. Nano Mater.

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“…Divya et al developed a novel thiophene based pyrrolo [1,2- a ] quinoxaline fluorescent sensor (TAAPP), which was suitable for the nanomolar detection of sodium ions. 37 The fluorescence quenching mechanism of TAAPP is shown in Fig. 2a.…”

Section: Fluorescent Detection Of Metal Ionsmentioning

confidence: 99%

Organic small-molecule fluorescent probe-based detection for alkali and alkaline earth metal ions in biological systems

Xing

Yuan

et al. 2023

J. Mater. Chem. B

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“…As an important class of nitrogen heterocyclic compounds, pyrrolo[1,2‐ α ]quinoxalines and their derivatives, contain two six‐membered rings and one five‐membered ring in their structures, and have excellent biological activities for compounds containing a pyrrolo[1,2‐ α ]quinoxaline fragment, such as anticancer, [1a] antitumor, antimalarial, [1b] inhibition of protein tyrosine phosphatase 1B, [1c] activation of Sirt2‐7, [1d] inhibition of the D‐ring activity of RAD51, [1e] etc. In addition, the three rings form a highly conjugated plane with large rigidity and exhibit extremely strong fluorescence, [2] and their modification by using different groups can modulate fluorescence of different colors, which can be used in organic electroluminescence, [3] chemical sensing detection, [4] fluorescent probe design, [5] etc, shown in Figure 1, therefore, the rapid construction of pyrrolo[1,2‐ α ]quinoxalines fragment is particularly important.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in the Catalytic Synthesis of Pyrrolo[1,2‐α]quinoxaline

Liu

Wang

2023

Asian J Org Chem

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Pyrrolo[1,2‐α]quinoxaline and its derivatives have excellent biological activity and photoelectric properties, and are widely used in the fields of pharmaceutical preparations and organic electroluminescence. This review starts from catalysts and summarizes the single metal catalysis of palladium, rhodium, iron, molybdenum, and copper, as well as the synergistic catalysis of iron molybdenum bimetallic and metal‐free catalytic systems for the synthesis of pyrrolo[1,2‐α]quinoxaline. The pyrrolo[1,2‐α]quinoxaline catalytic mechanism in the different catalytic systems was detailly introduced and analysed. By analysing the advantages and disadvantages of existing catalyst systems, the prospects of new catalysts and methods for synthesis of pyrrolo[1,2‐α]quinoxaline are presented.

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A thiophene based pyrrolo [1, 2-a] quinoxaline fluorescent probe as a “turn-off” sensor for the selective nanomolar detection of sodium ion

Cited by 9 publications

References 36 publications

Selective Determination of HOCl in Environmental Water Samples and Real-Time Detection of HOCl Levels in Live Cells via Ratio Fluorescence Imaging Based on Eu³⁺-Modified and Carbon Dot-Encapsulated Metal Organic Frameworks

Selective Determination of HOCl in Environmental Water Samples and Real-Time Detection of HOCl Levels in Live Cells via Ratio Fluorescence Imaging Based on Eu³⁺-Modified and Carbon Dot-Encapsulated Metal Organic Frameworks

Organic small-molecule fluorescent probe-based detection for alkali and alkaline earth metal ions in biological systems

Recent Progress in the Catalytic Synthesis of Pyrrolo[1,2‐α]quinoxaline

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A thiophene based pyrrolo [1, 2-a] quinoxaline fluorescent probe as a “turn-off” sensor for the selective nanomolar detection of sodium ion

Cited by 9 publications

References 36 publications

Selective Determination of HOCl in Environmental Water Samples and Real-Time Detection of HOCl Levels in Live Cells via Ratio Fluorescence Imaging Based on Eu3+-Modified and Carbon Dot-Encapsulated Metal Organic Frameworks

Selective Determination of HOCl in Environmental Water Samples and Real-Time Detection of HOCl Levels in Live Cells via Ratio Fluorescence Imaging Based on Eu3+-Modified and Carbon Dot-Encapsulated Metal Organic Frameworks

Organic small-molecule fluorescent probe-based detection for alkali and alkaline earth metal ions in biological systems

Recent Progress in the Catalytic Synthesis of Pyrrolo[1,2‐α]quinoxaline

Contact Info

Product

Resources

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Selective Determination of HOCl in Environmental Water Samples and Real-Time Detection of HOCl Levels in Live Cells via Ratio Fluorescence Imaging Based on Eu³⁺-Modified and Carbon Dot-Encapsulated Metal Organic Frameworks

Selective Determination of HOCl in Environmental Water Samples and Real-Time Detection of HOCl Levels in Live Cells via Ratio Fluorescence Imaging Based on Eu³⁺-Modified and Carbon Dot-Encapsulated Metal Organic Frameworks