A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γ

Tang, Xiao‐Tian; Arora, Gunjan; Matias, Jaqueline; Hart, Thomas; Cui, Yaya; Fikrig, Erol

doi:10.1016/j.celrep.2022.111673

Cited by 11 publications

(4 citation statements)

References 60 publications

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“…The attachment and engorgement weights of nymphs feeding on infected WT or KO mice were comparable (Fig 1D and 1E) and suggest adiponectin does not alter the ability of ticks to take a blood meal. As adiponectin encodes a C1q-like globular domain, and numerous C1q domain-containing proteins have high affinity for microbes [14][15][16][17], we then examined whether adiponectin directly interacts with B. burgdorferi. Flow cytometry showed adiponectin does not directly bind B. burgdorferi (Fig 2A).…”

Section: Adiponectin Deficiency Affects Borrelia Acquisition By Ticks...mentioning

confidence: 99%

“…Moreover, an adiponectin-homolog in tick, complement C1q-like protein 3, alters infectivity of B . burgdorferi by modulating host IFN-γ production [ 14 ]. In the present study, we investigated whether host serum adiponectin or its associated factors influence B .…”

Section: Introductionmentioning

confidence: 99%

“…Our recent study indicated a tick adiponectin receptor-like protein regulates phospholipid metabolism in tick gut, which is associated with colonization by the Lyme disease agent B. burgdorferi [13]. Moreover, an adiponectin-homolog in tick, complement C1q-like protein 3, alters infectivity of B. burgdorferi by modulating host IFN-γ production [14]. In the present study, we investigated whether host serum adiponectin or its associated factors influence B. burgdorferi acquisition or colonization by I. scapularis, since host blood is taken into the tick during a blood meal, and this is the primary method by which ticks acquire B. burgdorferi.…”

Section: Introductionmentioning

confidence: 99%

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Adiponectin in the mammalian host influences ticks’ acquisition of the Lyme disease pathogen Borrelia

Tang,

Cao,

Booth

et al. 2023

PLoS Biol

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Arthropod-borne pathogens cause some of the most important human and animal infectious diseases. Many vectors acquire or transmit pathogens through the process of blood feeding. Here, we report adiponectin, the most abundant adipocyte-derived hormone circulating in human blood, directly or indirectly inhibits acquisition of the Lyme disease agent, Borrelia burgdorferi, by Ixodes scapularis ticks. Rather than altering tick feeding or spirochete viability, adiponectin or its associated factors induces host histamine release when the tick feeds, which leads to vascular leakage, infiltration of neutrophils and macrophages, and inflammation at the bite site. Consistent with this, adiponectin-deficient mice have diminished pro-inflammatory responses, including interleukin (IL)-12 and IL-1β, following a tick bite, compared with wild-type animals. All these factors mediated by adiponectin or associated factors influence B. burgdorferi survival at the tick bite site. These results suggest a host adipocyte-derived hormone modulates pathogen acquisition by a blood-feeding arthropod.

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Section: Adiponectin Deficiency Affects Borrelia Acquisition By Ticks...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adiponectin in the mammalian host influences ticks’ acquisition of the Lyme disease pathogen Borrelia

Tang,

Cao,

Booth

et al. 2023

PLoS Biol

Self Cite

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“…To prevent this, Ixodes ticks secrete saliva into the feeding site, exposing the host to anticoagulants and immunomodulatory compounds, which dampens the host immune response and ensures the tick remains attached until completion of feeding [7][8][9]. This secretion also contributes to the spread of B. burgdorferi into new hosts-both by providing a mechanism to exit the tick [10][11][12] and by dampening the immune response while the pathogen establishes the infection [13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Peromyscus leucopus,Mus musculus, and humans have distinct transcriptomic responses to larvalIxodes scapularisbites

Bourgeois,

McCarthy,

Turk

et al. 2024

Preprint

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Ixodes scapularis ticks are an important vector for at least six tick-borne human pathogens, including the predominant North American Lyme disease spirochete Borrelia burgdorferi. The ability for these ticks to survive in nature is credited, in part, to their ability to feed on a variety of hosts without excessive activation of the proinflammatory branch of the vertebrate immune system. While the ability for nymphal ticks to feed on a variety of hosts has been well-documented, the host-parasite interactions between larval I. scapularis and different vertebrate hosts is relatively unexplored. Here we report on the changes in the vertebrate transcriptome present at the larval tick bite site using the natural I. scapularis host Peromyscus leucopus deermouse, a non-natural rodent host Mus musculus (BALB/c), and humans. We note substantially less evidence of activation of canonical proinflammatory pathways in P. leucopus compared to BALB/c mice and pronounced evidence of inflammation in humans. Pathway enrichment analyses revealed a particularly strong signature of interferon gamma, tumor necrosis factor, and interleukin 1 signaling at the BALB/c and human tick bite site. We also note that bite sites on BALB/c mice and humans, but not deermice, show activation of wound-healing pathways. These data provide molecular evidence of the coevolution between larval I. scapularis and P. leucopus as well as expand our overall understanding of I. scapularis feeding.

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Characterization and functional analysis of a novel C1q domain-containing protein from grass carp (Ctenopharyngodon idella) in response to bacterial challenge

A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γ

Cited by 11 publications

References 60 publications

Adiponectin in the mammalian host influences ticks’ acquisition of the Lyme disease pathogen Borrelia

Adiponectin in the mammalian host influences ticks’ acquisition of the Lyme disease pathogen Borrelia

Peromyscus leucopus,Mus musculus, and humans have distinct transcriptomic responses to larvalIxodes scapularisbites

Characterization and functional analysis of a novel C1q domain-containing protein from grass carp (Ctenopharyngodon idella) in response to bacterial challenge

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