2012
DOI: 10.1002/jbm.a.34256
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A tissue‐engineered aneurysm model for evaluation of endovascular devices

Abstract: Endovascular stent grafts used for treatment of arterial aneurysms require preclinical testing for investigation of biological responses following implantation. The preclinical evaluation process related to the safety and efficacy of these devices is limited by the absence of an in vitro aneurysmal blood vessel equivalent capable of providing high-throughput, cost-effective assessments. With this in mind, the focus of this work was to develop an aneurysm model consisting of human blood vessel cells. To create … Show more

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Cited by 7 publications
(7 citation statements)
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“…An in vivo porcine model of infrarenal aneurysm has been investigated [17], and porcine carotid arteries have previously been used ex vivo in a bioreactor to study the effect of stent implantation [18]. More recently, an in vitro bioreactor model of aneurysm has been described [19] in which PTFE grafts were firstly dilated with a balloon catheter and subsequently seeded with human SMC which over 14 days formed a full “neointima” over the dilated vessel.…”
Section: Introductionmentioning
confidence: 99%
“…An in vivo porcine model of infrarenal aneurysm has been investigated [17], and porcine carotid arteries have previously been used ex vivo in a bioreactor to study the effect of stent implantation [18]. More recently, an in vitro bioreactor model of aneurysm has been described [19] in which PTFE grafts were firstly dilated with a balloon catheter and subsequently seeded with human SMC which over 14 days formed a full “neointima” over the dilated vessel.…”
Section: Introductionmentioning
confidence: 99%
“…For this purpose, there are already studies showing the feasibility of TEBVs as an evaluation method for endovascular devices. [95][96][97][98] Two promising novel technologies add even more potential to the use of TE as an alternative to animal experimentation: three-dimensional bioprinting and organ-ona-chip. Bioprinting is a process that aims to deposit cells suspended in polymeric hydrogels onto a substrate, in a layer-by-layer manner, to build three-dimensional constructs analogous to tissues or organs.…”
Section: Te As a 3rs Strategymentioning
confidence: 99%
“…Study on stent materials can be conducted through in vitro and in vivo models. While animal models provide a complete biological environment, they are expensive and time consuming and this is difficult to perform studies with a high number of individuals 23,24 . In this case, bioreactors are widely used to represent a native surrounding and make it possible to observe and determine the influence of physiochemical environment 25 .…”
Section: Introductionmentioning
confidence: 99%