A-to-I–edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis

Xu, Xiaowu; Wang, Yumeng; Mojumdar, Kamalika; Zhou, Zhicheng; Jeong, Kang Jin; Mangala, Lingegowda S.; Yu, Shuangxing; Tsang, Yiu Huen; Rodríguez-Aguayo, Cristian; Lu, Yiling; López-Berestein, Gabriel; Sood, Anil K.; Mills, Gordon B.; Liang, Han

doi:10.1172/jci123396

Cited by 58 publications

(52 citation statements)

References 53 publications

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“…MiRNA retargeting in humans have been reported for miR-376a-5p edited at position 3 (redirecting from RAP2A to AMFR) [ 55 ], miR-200b-3p edited at position 5 (redirecting from ZEB1 to LIFR) [ 56 ], miR-589-3p (redirecting from PCDH9 to ADAM12) [ 57 ], and a few others. Finally, certain A-to-I editing events in miRNAs could cause simultaneous impairment of miRNA biogenesis and target redirecting, as might be the case of human miR-379-5p edited at position 5 [ 46 , 58 ].…”

Section: Effects Of A-to-i Mirna Editing On Mirna Biogenesis and Fmentioning

confidence: 99%

Detecting and Characterizing A-To-I microRNA Editing in Cancer

Marceca

Tomasello

Distefano

et al. 2021

Cancers

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Adenosine to inosine (A-to-I) editing consists of an RNA modification where single adenosines along the RNA sequence are converted into inosines. Such a biochemical transformation is catalyzed by enzymes belonging to the family of adenosine deaminases acting on RNA (ADARs) and occurs either co- or post-transcriptionally. The employment of powerful, high-throughput detection methods has recently revealed that A-to-I editing widely occurs in non-coding RNAs, including microRNAs (miRNAs). MiRNAs are a class of small regulatory non-coding RNAs (ncRNAs) acting as translation inhibitors, known to exert relevant roles in controlling cell cycle, proliferation, and cancer development. Indeed, a growing number of recent researches have evidenced the importance of miRNA editing in cancer biology by exploiting various detection and validation methods. Herein, we briefly overview early and currently available A-to-I miRNA editing detection and validation methods and discuss the significance of A-to-I miRNA editing in human cancer.

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Section: Effects Of A-to-i Mirna Editing On Mirna Biogenesis and Fmentioning

confidence: 99%

Detecting and Characterizing A-To-I microRNA Editing in Cancer

Marceca

Tomasello

Distefano

et al. 2021

Cancers

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“…And the ADAR2, which was identified as a promising target for an innovative anti-tumoral strategy, was treated as a radar enzyme that maintains a degree of editing in the miRNA population and balances miRNA expression [32]. It has been reported about the RNA editing in inhibiting cancer cell proliferation and differentiation [33], which focused on an ADAR2-catalyzed RNA editing site within microRNA seed region [34,35]. The present study suggested that the expression of miR-181a-5p has upregulated on MSCs chondrogenic differentiation, which was due to the editing by ADAR2 enzyme.…”

Section: Discussionmentioning

confidence: 99%

Atractylodes Lancea Volatile Oils Target ADAR2-miR-181a-5p Signaling to Mesenchymal Stem Cells Chondrogenic Differentiation

Ye¹,

Si²,

Qin³

et al. 2021

Preprint

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Background：The Rhizoma Atractylodis has long been recommended for the treatment of different diseases in traditional Chinese medicine. The main component of Rhizoma Atractylodis is Atractylodes lancea volatile oils which possesses anti-microorganism, anti-tumor, cognitive protection and immunoregulation. The aim of the study was to elucidate the mechanism of Atractylodes lancea volatile oils promoting mesenchymal stem cells (MSCs) chondrogenic differentiation. Method：Atractylodes lancea volatile oils were extracted from Chinese medicine Cangzhu by volatile oil extractor. MSCs culture were treated with Atractylodes lancea volatile oils medium. Real-time reverse transcription PCR was conducted to verify the candidate microRNAs discovered by microarray analysis. Western-blot analyzed the expressions of mark genes. Sanger sequences identified the changes of the base pairs which would be edited by ADAR2 enzyme. Toluidine blue staining identified the changes of cells chondrogenic differentiation. Result：Treatment of Atractylodes lancea volatile oils increased the cells chondrogenic differentiation of MSCs. Atractylodes lancea volatile oils promoted the expression of ADAR2 enzyme which may edit the precursor of miR-181a-5p. A dual luciferase reporter system assay verified that transcription factors yingyang1(YY1) was targeted by miR-181a-5p which was downregulated in MSCs chondrogenic differentiation. Conclusion：This work demonstrates the mechanism of Atractylodes lancea volatile oils promoting MSCs to chondrogenic differentiation. It may provide an alternative strategy for treatment purposes and diagnosis in clinic.

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“…For instance, compared to the wild-type miRNA, the edited miR-200b could increase the invasion and migration of cancer cells [141]. In another study, it was shown that the edited miR-379-5p, as opposed to the wild-type miR-379-5p that targets CD97, suppressed rapid cell proliferation and increased apoptosis in tumor cells in-vitro [142]. Table 1 and Fig.…”

Section: Regulation Of Autophagy By Micrornas In Cancermentioning

confidence: 93%

Autophagy in cancers including brain tumors: role of MicroRNAs

et al. 2020

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Autophagy has a crucial role in many cancers, including brain tumors. Several types of endogenous molecules (e.g. microRNAs, AKT, PTEN, p53, EGFR, and NF1) can modulate the process of autophagy. Recently miRNAs (small noncoding RNAs) have been found to play a vital role in the regulation of different cellular and molecular processes, such as autophagy. Deregulation of these molecules is associated with the development and progression of different pathological conditions, including brain tumors. It was found that miRNAs are epigenetic regulators, which influence the level of proteins coded by the targeted mRNAs with any modification of the genetic sequences. It has been revealed that various miRNAs (e.g., miR-7-1-3p, miR-340, miR-17, miR-30a, miR-224-3p, and miR-93), as epigenetic regulators, can modulate autophagy pathways within brain tumors. A deeper understanding of the underlying molecular targets of miRNAs, and their function in autophagy pathways could contribute to the development of new treatment methods for patients with brain tumors. In this review, we summarize the various miRNAs, which are involved in regulating autophagy in brain tumors. Moreover, we highlight the role of miRNAs in autophagy-related pathways in different cancers.

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A-to-I–edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis

Cited by 58 publications

References 53 publications

Detecting and Characterizing A-To-I microRNA Editing in Cancer

Detecting and Characterizing A-To-I microRNA Editing in Cancer

Atractylodes Lancea Volatile Oils Target ADAR2-miR-181a-5p Signaling to Mesenchymal Stem Cells Chondrogenic Differentiation

Autophagy in cancers including brain tumors: role of MicroRNAs

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