This paper presents a method to extract change information from temporal
mammogram pairs and to incorporate the temporal change information in the
malignant mass classification. In this method, a temporal mammogram
registration framework which is based on spatial relations between regions
of interest and graph matching was used to create correspondences between
regions of current mammogram and regions of previous mammogram. 18 image
features were then used to capture the differences (temporal changes)
between the matched regions. To assess the contribution of temporal change
information to the mass detection, 5 methods were designed to combine mass
classification on image features measured on single regions and mass
classification on temporal features to improve overall mass classification.
The method was tested on 95 pairs of temporal mammograms using k-fold cross
validation procedure. The experimental results showed that, when combining
two classification results using linear combination or by taking minimum
value, the Az score of overall classification performance increased from
0.8843 to 0.8989 and 0.8863 respectively. The results demonstrated that
registering temporal mammograms, measuring temporal changes from matched
regions and incorporating the change information in the mass classification
improves the overall mass detection.