A Topologically Engineered Gold Island for Programmed In Vivo Stem Cell Manipulation

Qu, Xiaogang; Cui, Tingting; Wu, Si; Wei, Yunrong; Qin, Hongshuang; Ren, Jinsong

doi:10.1002/anie.202113103

Cited by 10 publications

(4 citation statements)

References 68 publications

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“…In addition, other transition metal ions, including lanthanide ions, Zn 2+ , Mn 2+ , Cu 2+ , Fe 2+ , and Ni 2+ also show nucleic acid cleavage activity. [91,[115][116][117][118][119] These transition metals contain free coordination sites for the binding with phosphoryl oxygen, and can act as effective nucleophilic reagents by ligating with water or hydroxide and nucleophilic attack to hydrolyze the phosphodiester bonds.…”

Section: Nuclease Mimeticsmentioning

confidence: 99%

Polyoxometalates as Potential Artificial Enzymes toward Biological Applications

Li,

Xu,

et al. 2023

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Artificial enzymes, as alternatives to natural enzymes, have attracted enormous attention in the fields of catalysis, biosensing, diagnostics, and therapeutics because of their high stability and low cost. Polyoxometalates (POMs), a class of inorganic metal oxides, have recently shown great potential in mimicking enzyme activity due to their well‐defined structure, tunable composition, high catalytic efficiency, and easy storage properties. This review focuses on the recent advances in POM‐based artificial enzymes. Different types of POMs and their derivatives‐based mimetic enzyme functions are covered, as well as the corresponding catalytic mechanisms (where available). An overview of the broad applications of representative POM‐based artificial enzymes from biosensing to theragnostic is provided. Insight into the current challenges and the future directions for POMs‐based artificial enzymes is discussed.

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Section: Nuclease Mimeticsmentioning

confidence: 99%

Polyoxometalates as Potential Artificial Enzymes toward Biological Applications

Li,

Xu,

et al. 2023

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“…Moreover, the MNPs coupled with RGD-grafted Au features were magnetically manipulated for the monitoring and regulation of stem cell differentiation. [94][95][96] Magnetically controlled axial movement has allowed the liganded nanostructure to move either upward (away from the substrate) or downward (toward the substrate), thereby controlling the ligand stability. Stem cells cultured in the magnetic upward group showed relatively low stem cell adhesion and differentiation that was shown to be opposite in those cultured in the magnetic downward group.…”

Section: Magnetic Control Of Dynamic Nanoscale Featuresmentioning

confidence: 99%

Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy

Hong

Choi

et al. 2022

Advanced NanoBiomed Research

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Dynamic therapy is a key research area for noninvasive clinical therapeutics. Up to now, light, electricity, ultrasound, and magnetic field have been investigated for the potential remote cellular regulation tools. Opening ion channels, activating cell death, and manipulating individual receptors that can control various cellular signal pathways have been suggested using external energy forms that can be dynamically applied in situ, which advance from the static control strategies. [1][2][3][4] For instance, optogenetics using light [5,6] have greatly advanced cellular modulation over the past decades, especially for neuromodulation. [7] Other energy sources have also been demonstrated with promising potential for regulating cellular metabolism and death. However, controlling the penetration and localization of energy sources (e.g., light and electricity) in tissues and cells have been challenging for in vivo applications. On the other hand, a magnetic field can safely penetrate deep tissues, which is particularly relevant for clinical applications. Consequently, utilizing the magnetic field to manipulate the MNPs is emerging as an effective approach to dynamically regulate cellular activity. [8] Recent advancements of multifunctional MNPs, spintronics, and magnetogenetics have enabled precise modulation of magnetic field gradients and pulses to remotely control the movement, heat generation, and reactive oxygen species (ROS) generation of the MNPs (Figure 1).Engineering multifunctional magnetic particles is the key requirement to achieve desired biomedical applications. [9][10][11] In the past 20 years, MNPs have received increasing attention

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“…Integrins, the main cellular receptors for the extracellular matrix, have a key role in mediating these activities. , The tripeptide Arg-Gly-Asp or RGD is one of the highly conserved peptide sequences present in the extracellular matrix (ECM) recognized by the integrins. Since its discovery, this peptide sequence and its variations have been integrated into and onto a variety of scaffolds to investigate the role of cell adhesion molecules during cell adhesion processes and fabrication of biomaterials for cell culture, tissue engineering, and regenerative medicine. − The scaffolds for immobilizing bioactive peptides can be either static (biopolymers, self-assembled monolayers (SAMs) − ) or dynamic (hydrogels, , supported lipid bilayers (SLBs), host–guest-based assemblies, − self-assembled peptide amphiphiles). In terms of two-dimensional (2D) crystalline-like layers, the most well-studied cases are SAMs and SLBs. ,,,, The former in combination with light-responsive, , magnetic, or electrical-responsive functionalities, ,, or host–guest-based chemistry, − enable controllable surface properties for reversible cell adhesion albeit featuring only short-range dynamic properties.…”

Section: Introductionmentioning

confidence: 99%

Reversible Self-Assembled Monolayers with Tunable Surface Dynamics for Controlling Cell Adhesion Behavior

Yeung

Sergeeva

Pan

et al. 2022

ACS Appl. Mater. Interfaces

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Cells adhering onto surfaces sense and respond to chemical and physical surface features. The control over cell adhesion behavior influences cell migration, proliferation, and differentiation, which are important considerations in biomaterial design for cell culture, tissue engineering, and regenerative medicine. Here, we report on a supramolecular-based approach to prepare reversible self-assembled monolayers (rSAMs) with tunable lateral mobility and dynamic control over surface composition to regulate cell adhesion behavior. These layers were prepared by incubating oxoacid-terminated thiol SAMs on gold in a pH 8 HEPES buffer solution containing different mole fractions of ω-(ethylene glycol)2‑4- and ω-(GRGDS)-, α-benzamidino bolaamphiphiles. Cell shape and morphology were influenced by the strength of the interactions between the amidine-functionalized amphiphiles and the oxoacid of the underlying SAMs. Dynamic control over surface composition, achieved by the addition of inert filler amphiphiles to the RGD-functionalized rSAMs, reversed the cell adhesion process. In summary, rSAMs featuring mobile bioactive ligands offer unique capabilities to influence and control cell adhesion behavior, suggesting a broad use in biomaterial design, tissue engineering, and regenerative medicine.

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A Topologically Engineered Gold Island for Programmed In Vivo Stem Cell Manipulation

Cited by 10 publications

References 68 publications

Polyoxometalates as Potential Artificial Enzymes toward Biological Applications

Polyoxometalates as Potential Artificial Enzymes toward Biological Applications

Multifunctional Magnetic Nanoparticles for Dynamic Imaging and Therapy

Reversible Self-Assembled Monolayers with Tunable Surface Dynamics for Controlling Cell Adhesion Behavior

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