A Trace Amount of Surfactants Enables Diffusiophoretic Swimming of Bacteria

Doan, Viet Sang; Saingam, Prakit; Yan, Tao; Shin, Sangwoo

doi:10.1021/acsnano.0c07502

Cited by 24 publications

(28 citation statements)

References 73 publications

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“…Bacterial cells were introduced along a microchannel containing a low concentration of NaCl (8.55 mM) solution, which was connected to another microchannel filled with M9 medium containing a high concentration of NaCl (1.5 M) to induce diffusiophoresis, resulting in a single bacterial cell that was successfully captured in the microfunnels. Furthermore, Doan et al [ 109 ] demonstrated that even a trace concentration of ionic surfactants, lowered to a single ppm level, can promote bacterial diffusiophoresis by boosting the surface charge of the cells, which were applied for various bacterial strains, such as E. coli (EC), E. faecalis (EF), S. enterica (SE), and V. parahemolyticus (VP), as shown in Figure 3 C(ii).…”

Section: Passive Separation Group 2: Gradient-based Separationmentioning

confidence: 99%

“…This functionalization using a strong binding affinity enables selective and sensitive separation of specific bioparticles. In conventional batch bioprocesses, the magnetic force-based separation is one of the most popular methods for extracting specific bioparticles from complex biosample matrices [ 109 ] by a serial combination of centrifugation or membrane filtration. However, continuous sample handling, minimization of run-by-run errors, and application to small sample volumes remain challenges.…”

Section: Active Separation Group 1: Non-contacting Mechanical Forcesmentioning

confidence: 99%

“…Negatively charged bacterial cells moved toward high salt concentration channel by salt concentration gradient. Reprinted with permission from the American Chemical Society [ 109 ]. All rights reserved.…”

Section: Figurementioning

confidence: 99%

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Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles

Choe

Kim

2021

Biosensors

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Separation of micro- and nano-sized biological particles, such as cells, proteins, and nucleotides, is at the heart of most biochemical sensing/analysis, including in vitro biosensing, diagnostics, drug development, proteomics, and genomics. However, most of the conventional particle separation techniques are based on membrane filtration techniques, whose efficiency is limited by membrane characteristics, such as pore size, porosity, surface charge density, or biocompatibility, which results in a reduction in the separation efficiency of bioparticles of various sizes and types. In addition, since other conventional separation methods, such as centrifugation, chromatography, and precipitation, are difficult to perform in a continuous manner, requiring multiple preparation steps with a relatively large minimum sample volume is necessary for stable bioprocessing. Recently, microfluidic engineering enables more efficient separation in a continuous flow with rapid processing of small volumes of rare biological samples, such as DNA, proteins, viruses, exosomes, and even cells. In this paper, we present a comprehensive review of the recent advances in microfluidic separation of micro-/nano-sized bioparticles by summarizing the physical principles behind the separation system and practical examples of biomedical applications.

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Section: Passive Separation Group 2: Gradient-based Separationmentioning

confidence: 99%

Section: Active Separation Group 1: Non-contacting Mechanical Forcesmentioning

confidence: 99%

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Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles

Choe

Kim

2021

Biosensors

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“…Particle zeta potential was obtained by measuring their diffusiophoretic mobilities in microfluidic dead-end pores. The details of this technique can be found in our previous studies [19][20][21][22][23]. By utilizing diffusiophoresis, this technique provides a simple and reliable method for measuring the particle zeta potential.…”

Section: Colloid Preparation and Characterizationmentioning

confidence: 99%

Formation of a colloidal band via pH‐dependent electrokinetics

Doan

Shin

2021

Electrophoresis

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Electroosmosis on nonuniformly charged surfaces often gives rise to intriguing flow behaviors, which can be utilized in applications such as mixing processes and designing micromotors. Here, we demonstrate nonuniform electroosmosis induced by electrochemical reactions. Water electrolysis creates pH gradients near the electrodes that cause a spatiotemporal change in the wall zeta potential, leading to nonuniform electroosmosis. Such nonuniform EOFs induce multiple vortices, which promote the continuous accumulation of particles that subsequently form a colloidal band. The band develops vertically into a “wall” of particles that spans from the bottom to the top surface of the chamber. Such a flow‐driven colloidal band can be potentially used in colloidal self‐assembly and separation processes irrespective of the particle surface properties. For instance, we demonstrate these vortices can promote rapid segregation of soft colloids such as oil droplets and fat globules.

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“…In particular, many important experimental studies were reported by Shin et al. recently to broaden the potential practical applications of diffusiophoresis [14–16].…”

Section: Introductionmentioning

confidence: 99%

Diffusiophoresis of a highly charged soft particle normal to a conducting plane

Lee

2021

Electrophoresis

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Diffusiophoresis of a soft particle in electrolyte solutions normal to a conducting solid plane is investigated theoretically in this study, focusing on the highly charged particle in particular. A pseudo‐spectral method based on Chebyshev polynomial is adopted to solve the resultant governing electrokinetic equations. It was found, among other things, that the closer the soft particle is to the plane, the faster it moves in general, provided only the chemiphoresis component of the diffusiophoresis is involved, i.e., no diffusion potential is present. The presence of the conducting plane is found to have three effects upon the particle motion nearby: the geometric boundary confinement effect, the electrostatic mirror‐image force analog effect, and the hydrodynamic retarding effect. The enhancement of the double layer polarization by the first two effects leads to the seeming intriguing observation mentioned above. The particle always moves away from the plane in chemiphoresis. If a diffusion potential is present, however, then it is possible to drive the particle toward the plane. The results have potential applications in drug delivery.

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A Trace Amount of Surfactants Enables Diffusiophoretic Swimming of Bacteria

Cited by 24 publications

References 73 publications

Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles

Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles

Formation of a colloidal band via pH‐dependent electrokinetics

Diffusiophoresis of a highly charged soft particle normal to a conducting plane

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