A transformable nanoplatform with multiple therapeutic and immunostimulatory properties for treatment of advanced cancers

Xue, Xiangdong; Qu, Haijing; Bo, Ruonan; Zhang, Dalin; Zhu, Zheng; Xiang, Bingren; Li, Longmeng; Ricci, Marina; Pan, Chong‐Xian; Lin, Tzu‐Yin; Li, Yuanpei

doi:10.1016/j.biomaterials.2023.122145

Cited by 14 publications

(3 citation statements)

References 36 publications

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“…In recent years, tumor immunotherapy has been regarded as the most promising therapeutic strategy. − Nevertheless, the inherent immunosuppressive microenvironment of the tumor greatly reduces the effectiveness of the immunotherapy. Therefore, the elimination of immunosuppressive factors is a critical method for immunotherapy. − Transforming growth factor-β (TGF-β), as an immunosuppressive cytokine in the tumor microenvironment, has been shown to promote tumor immune escape and metastasis, making it a critical target for immunotherapy. − Additionally, TGF-β also plays a pivotal role in tumor-induced hyperalgesia. − Therefore, the efficient inhibition of TGF-β within the tumor extracellular matrix can mitigate tumor-induced immunosuppression and alleviate cancer-associated pain. Curcumin (CUR), derived from the traditional turmeric spice, is known for its anti-inflammatory, antioxidant, and anticancer characteristics. , Furthermore, recent studies have reported that CUR can inhibit TGF-β production. , It was also found that CUR can combine with calcium ions (Ca 2+ ) to promote their enrichment in tumors, leading to tumor inhibition through calcium overload .…”

Section: Introductionmentioning

confidence: 99%

Calcium Carbonate/Polydopamine Composite Nanoplatform Based on TGF-β Blockade for Comfortable Cancer Immunotherapy

Li,

Wang,

Sun

et al. 2024

ACS Appl. Mater. Interfaces

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Cancer pain seriously reduces the quality of life of cancer patients. However, most research about cancer focuses solely on inhibiting tumor growth, neglecting the issue of cancer pain. Therefore, the development of therapeutic agents with both tumor suppression and cancer pain relief is crucial to achieve human-centered treatment. Here, the work reports curcumin (CUR) and ropivacaine (Ropi) coincorporating CaCO 3 /PDA nanoparticles (CaPNM CUR+Ropi ) that realized efficient tumor immunotherapy and cancer pain suppression. The therapeutic efficiency and mechanism are revealed in vitro and in vivo. The results indicate that CaPNM CUR+Ropi underwent tumor microenvironment-responsive degradation and realized rapid release of calcium ions, Ropi, and CUR. The excessive intracellular calcium triggered the apoptosis of tumor cells, and the transient pain caused by the tumor injection was relieved by Ropi. Simultaneously, CUR reduced the levels of immunosuppressive factor (TGF-β) and inflammatory factor (IL-6, IL-1β, and TNF-α) in the tumor microenvironment, thereby continuously augmenting the immune response and alleviating inflammatory pain of cancer animals. Meanwhile, the decrease of TGF-β leads to the reduction of transient receptor potential vanilloid 1 (TRPV1) expression, thereby alleviating hyperalgesia and achieving long-lasting analgesic effects. The design of the nanosystem provides a novel idea for humancentered tumor treatment in the future.

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Section: Introductionmentioning

confidence: 99%

Calcium Carbonate/Polydopamine Composite Nanoplatform Based on TGF-β Blockade for Comfortable Cancer Immunotherapy

Li,

Wang,

Sun

et al. 2024

ACS Appl. Mater. Interfaces

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“…These include surface modification of carriers with tumor cell-specific receptors to achieve targeted drug delivery to the tumor [ 2 , 3 ]. Alternatively, structural alterations of the carrier can be implemented to transition from larger to smaller morphologies, thereby enhancing intratumoral penetration efficiency [ 4 , 5 ]. Additionally, utilizing endocytosis facilitates carrier transmission between tumor cells, enabling deep-seated delivery of the carrier to the tumor [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Achieving deep intratumoral penetration and multimodal combined therapy for tumor through algal photosynthesis

Zhang,

Liu

et al. 2024

J Nanobiotechnol

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Background Elevated interstitial fluid pressure within tumors, resulting from impaired lymphatic drainage, constitutes a critical barrier to effective drug penetration and therapeutic outcomes. Results In this study, based on the photosynthetic characteristics of algae, an active drug carrier (CP@ICG) derived from Chlorella pyrenoidosa (CP) was designed and constructed. Leveraging the hypoxia tropism and phototropism exhibited by CP, we achieved targeted transport of the carrier to tumor sites. Additionally, dual near-infrared (NIR) irradiation at the tumor site facilitated photosynthesis in CP, enabling the breakdown of excessive intratumoral interstitial fluid by generating oxygen from water decomposition. This process effectively reduced the interstitial pressure, thereby promoting enhanced perfusion of blood into the tumor, significantly improving deep-seated penetration of chemotherapeutic agents, and alleviating tumor hypoxia. Conclusions CP@ICG demonstrated a combined effect of photothermal/photodynamic/starvation therapy, exhibiting excellent in vitro/in vivo anti-tumor efficacy and favorable biocompatibility. This work provides a scientific foundation for the application of microbial-enhanced intratumoral drug delivery and tumor therapy. Graphical Abstract

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“…Nanomedicines have shown significant promise in the administration of therapeutics that are otherwise unresponsive to conventional drug-based treatments for various diseases. − Considering the considerable influence of surface traits on the in vivo behaviors of nanomedicines, many modifications have been employed to alter their surface properties. Among these techniques, PEGylation stands out as the most commonly utilized approach.…”

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confidence: 99%

Biomimetic Lung-Targeting Nanoparticles with Antioxidative and Nrf2 Activating Properties for Treating Ischemia/Reperfusion-Induced Acute Lung Injury

Wang,

Dong,

et al. 2024

Nano Lett.

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Ischemia/reperfusion (IR)-induced acute lung injury (ALI) has a high mortality rate. Reactive oxygen species (ROS) play a crucial role in causing cellular damage and death in IR-induced ALI. In this work, we developed a biomimetic lung-targeting nanoparticle (PC@MB) as an antioxidative lung protector for treating IR-induced ALI. PC@MBs showed excellent ROS scavenging and Nrf2 activation properties, along with a lungtargeting function through autologous cell membrane coating. The PC@MBs exhibited an impressive antioxidative and pulmonary protective role via redox homeostasis recovery through Nrf2 and heme oxygenase-1 activation. PC@ MBs could maintain cell viability by effectively scavenging the intracellular ROS and restoring the redox equilibrium in the lesion. In the IR mouse model, the PC@MBs preferentially accumulated in the lung and distinctly repaired the pneumonic damage. Our strategy has the potential to offer a promising therapeutic paradigm for treating IR-induced ALI through the incorporation of different therapeutic mechanisms.

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A transformable nanoplatform with multiple therapeutic and immunostimulatory properties for treatment of advanced cancers

Cited by 14 publications

References 36 publications

Calcium Carbonate/Polydopamine Composite Nanoplatform Based on TGF-β Blockade for Comfortable Cancer Immunotherapy

Calcium Carbonate/Polydopamine Composite Nanoplatform Based on TGF-β Blockade for Comfortable Cancer Immunotherapy

Achieving deep intratumoral penetration and multimodal combined therapy for tumor through algal photosynthesis

Biomimetic Lung-Targeting Nanoparticles with Antioxidative and Nrf2 Activating Properties for Treating Ischemia/Reperfusion-Induced Acute Lung Injury

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