A treatment planning study to assess the feasibility of laser‐driven proton therapy using a compact gantry design

Hofmann, K.; Masood, Umar; Pawelke, J.; Wilkens, Jan J.

doi:10.1118/1.4927717

Cited by 14 publications

(9 citation statements)

References 35 publications

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“…It is recognized that there are significant challenges ahead before laser-driven ion beams capable of meeting therapeutic specifications, both in terms of energy, repetition rate and general reliability, may become available. However, several authors have started to consider how a laser-driven treatment could be delivered, for example designing reduced size magnetic delivery systems (gantries) [94] or developing treatment plans tailored to the characteristics of TNSA beams [95,96]. Another significant development in this area is the future availability of laser-driven proton beamlines with controlled output parameters, which will allow significant progress in preclinical work (e.g.…”

Section: Cancer Therapymentioning

confidence: 99%

Ion Acceleration: TNSA and Beyond

Borghesi

2019

Springer Proceedings in Physics

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This paper reviews experimental progress in laser-driven ion acceleration as well as discussing some of the current and foreseen applications employing laser-accelerated beams of ions. While sheath acceleration processes initiated by high-intensity irradiation of solid foils (the so-called target Normal Sheath Acceleration, TNSA) have now been studied for more than two decades, novel processes which can accelerate ions from the bulk of the irradiated target have emerged more recently. We will summarize the basic physics behind all these mechanisms, as well as briefly reporting current experimental evidence.

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Section: Cancer Therapymentioning

confidence: 99%

Ion Acceleration: TNSA and Beyond

Borghesi

2019

Springer Proceedings in Physics

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“…Subsequently, a pillar beam-line was required to distinguish the dissimilar particle beam with an energy range directing this beam to the patient and considers a defined dose delivery. In order to empower a patient particle delivery, the beam-line should offer an energy choice framework to pick the desired parts from the primary particle spectrum [6]. Moreover, citing the ions as proper transducers, the Bragg curve of three ions: Carbon, Neon, and Oxygen was illustrated and compared respectively and it was demonstrated that Oxygen ion is the best particle in Hadron therapy due to its minor energy dissipation through matter on its path to the tumor.…”

Section: This Amount Of Ion Beams Advances the Arrangement Of Onementioning

confidence: 99%

Hadron Therapy Based on Laser Acceleration in the Plasma Channel Using Oxygen Ionization

Alviri

Asem

2019

IEEE Access

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In a cancer radiation treatment, Hadron therapy plays an important role as a technique with a high accuracy providing treatment results better than conventional radiation therapy methods such as chemotherapy. The laser-based Hadron therapy techniques are attractive due to their compactness in producing miniaturized particle accelerators and supporting a more intense electric field compared to other methods. A good-quality laser beam focusing and guiding in a cold plasma channel leads to an accurate and precise laser spot after focus, which is an important necessity in medical aims and occurs in µm-wavelength (ultra-short pulse) laser types. A method used to level up this treatment approach has been emerged by using high-power lasers along with plasma channels as a source for high energy to more effectively perform the Hadron therapy. Additionally, cancer treatment by using ions as the particle transferor is preferred over other methods for Hadron therapy due to some physical properties such as maximum energy deposition to the cancerous targets providing a better dose delivery to the tumor. In this paper, multiple simulations around the dose delivery procedures were presented for efficient dosimetric evaluations. Moreover, the effects of the electric field on the particle energy enhancement were evaluated in the presence of the plasma channel. Finally, it was demonstrated that the use of Oxygen ion in the presence of plasma channel is the appropriate approach due to its minor energy dissipation through matter on the way to the tumor for a better dose delivery which was impressed with radially polarized laser accelerator simultaneously. The proposed research demonstrated that the Hadrons can reach the maximum accelerated energy and convey the maximum path through the body to the cancerous target and finally deliver the sufficient dose to the tumor by using Oxygen ion beam in a cold plasma channel, which is low in density, with appropriate laser power. Consequently, Hadron therapy by using Oxygen ionization in the laser-plasma based accelerator is an impressive and efficient method for precise cancer treatment. Lastly, Laser-Plasma accelerators have three important limitation factors of ''Energy Spread'', ''Dephasing Length'', and ''Pump Depletion'', which can limit the energy increasing. In this paper, facing up to these limitations was a critical challenge in Hadron therapy for better Hadron acceleration and dose delivery.

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“…Delivery of a clinical dose has been studied for axial clustering. Supposing a typical TNSA energy spectrum from a laser accelerator is transported through the suggested gantry (Figure 3), the number of beam pulses for patient irradiation is dependent on the number of protons accelerated by the laser [27]. For an initial proton number of about 3 Â 10 9 treatment plans with a sufficiently small number of pulses can be generated for small or medium sized tumors.…”

Section: Dose Delivery Proceduresmentioning

confidence: 99%

“…For an initial proton number of about 3 Â 10 9 treatment plans with a sufficiently small number of pulses can be generated for small or medium sized tumors. Pulseto-pulse fluctuations in the initial proton number may cancel in some cases [27], but exact stability requirements need further investigation. Additionally, the laterally clustering has to be considered.…”

Section: Dose Delivery Proceduresmentioning

confidence: 99%

Towards ion beam therapy based on laser plasma accelerators

et al. 2017

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Only few ten radiotherapy facilities worldwide provide ion beams, in spite of their physical advantage of better achievable tumor conformity of the dose compared to conventional photon beams. Since, mainly the large size and high costs hinder their wider spread, great efforts are ongoing to develop more compact ion therapy facilities. One promising approach for smaller facilities is the acceleration of ions on micrometre scale by high intensity lasers. Laser accelerators deliver pulsed beams with a low pulse repetition rate, but a high number of ions per pulse, broad energy spectra and high divergences. A clinical use of a laser based ion beam facility requires not only a laser accelerator providing beams of therapeutic quality, but also new approaches for beam transport, dosimetric control and tumor conformal dose delivery procedure together with the knowledge of the radiobiological effectiveness of laser-driven beams. Over the last decade research was mainly focused on protons and progress was achieved in all important challenges. Although currently the maximum proton energy is not yet high enough for patient irradiation, suggestions and solutions have been reported for compact beam transport and dose delivery procedures, respectively, as well as for precise dosimetric control. Radiobiological in vitro and in vivo studies show no indications of an altered biological effectiveness of laser-driven beams. Laser based facilities will hardly improve the availability of ion beams for patient treatment in the next decade. Nevertheless, there are possibilities for a need of laser based therapy facilities in future.

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A treatment planning study to assess the feasibility of laser‐driven proton therapy using a compact gantry design

Cited by 14 publications

References 35 publications

Ion Acceleration: TNSA and Beyond

Ion Acceleration: TNSA and Beyond

Hadron Therapy Based on Laser Acceleration in the Plasma Channel Using Oxygen Ionization

Towards ion beam therapy based on laser plasma accelerators

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