A tribological assessment of a PEEK based self-mating total cervical disc replacement

Hua, Xueming; Shepherd, Duncan E.T.; Dearn, Karl D.

doi:10.1016/j.wear.2013.03.052

Cited by 45 publications

(19 citation statements)

References 25 publications

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“…Additionally a study on the size, aspect ratio and roundness of debris from periprosthetic tissue of SB Charité III TDRs found very similar ECD and aspect ratio distributions [32,33]. This validates both the kinematics of in vitro simulations of TDRs using a Bose ElectroForce Spinal Disc Fatigue/Wear system-in part validating other studies using the same procedure, such as those conducted by Moghadas [34] or Xin [35], and the observational algorithms used to generate this data.…”

Section: Discussionsupporting

confidence: 77%

The evolution of polymer wear debris from total disc arthroplasty

2015

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a b s t r a c tTotal disc arthroplasty is an alternative to spinal fusion, aimed at preserving flexibility; these devices typically involve a cobalt chrome molybdenum alloy socket articulating against an ultra-high molecular weight polyethylene (UHMWPE) ball. As with all artificial joints, wear debris is of particular concern due to its effect on both implant life and the in vivo biological reactions that can occur. In this paper, a profile of the UHMWPE wear debris generated from disc arthroplasty, tested on a spine simulator, is built with a combination of SEM image analysis tools. SEM images were analysed by computer vision, which allowed size and shape information to be extracted and images to be categorised by the shared topological features on individual wear particles. The computer visions techniques were based on a Scale Invariant Feature Transform (SIFT) to extract key point data from individual images and a Support Vector Decision Machine (SVM) to filter images based on a series of trained parameters. As certain wear particle morphology is predominantly produced by a particular wear regime, grouping wear particles by morphology and size made it possible to infer the relative rates of various wear regimes responsible for wear debris generation. By sampling synovial lubricant at intervals throughout the tribological test, the predominant wear regimes and particle sizes were tracked over the course of the implant life. Wear debris samples were taken at 12 intervals over a 5 million cycle test. The majority of debris was found to be 0.88 μm in equivalent circle diameter, with an aspect ratio (defined as the major over the minor diameter of the smallest possible encompassing ellipse of the debris) of 1.55. There was a decreasing trend in average particle size as the number of cycles increased. During the early stages of the test, adhesion and abrasion were dominant in forming particle morphologies, however after 2 million cycles; particles generated as a result of fatigue became the major particle morphology.

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Section: Discussionsupporting

confidence: 77%

The evolution of polymer wear debris from total disc arthroplasty

2015

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“…Only one carbon fiber-reinforced PEEK (CFR-PEEK) total hip arthroplasty (THA) (ABG II Hip System; Stryker SA, Montreux, CH) [ 35 , 36 ] and one unfilled PEEK nucleus replacement device (NUBAC™; Pioneer Surgical Technology, Marquette, MI, USA) [ 5 ] have been evaluated clinically. However, currently no PEEK-based TJA device has been cleared by the FDA for patient use, although the use of PEEK for cervical disc replacement [ 49 ] is under consideration. PEEK composites have shown in vitro wear properties comparable to metal-on-metal bearing couples [ 5 , 38 , 46 ] and are commonly used in trauma implants and spinal fixation devices [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

The Biologic Response to Polyetheretherketone (PEEK) Wear Particles in Total Joint Replacement: A Systematic Review

Stratton‐Powell

Pasko

Brockett

et al. 2016

Clinical Orthopaedics &Amp; Related Research

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BackgroundPolyetheretherketone (PEEK) and its composites are polymers resistant to fatigue strain, radiologically transparent, and have mechanical properties suitable for a range of orthopaedic applications. In bulk form, PEEK composites are generally accepted as biocompatible. In particulate form, however, the biologic response relevant to joint replacement devices remains unclear. The biologic response to wear particles affects the longevity of total joint arthroplasties. Particles in the phagocytozable size range of 0.1 µm to 10 µm are considered the most biologically reactive, particularly particles with a mean size of < 1 µm. This systematic review aimed to identify the current evidence for the biologic response to PEEK-based wear debris from total joint arthroplasties.Questions/purposes(1) What are the quantitative characteristics of PEEK-based wear particles produced by total joint arthroplasties? (2) Do PEEK wear particles cause an adverse biologic response when compared with UHMWPE or a similar negative control biomaterial? (3) Is the biologic response affected by particle characteristics?MethodsEmbase and Ovid Medline databases were searched for studies that quantified PEEK-based particle characteristics and/or investigated the biologic response to PEEK-based particles relevant to total joint arthroplasties. The keyword search included brands of PEEK (eg, MITCH, MOTIS) or variations of PEEK types and nomenclature (eg, PAEK, CFR-PEEK) in combination with types of joint (eg, hip, knee) and synonyms for wear debris or immunologic response (eg, particles, cytotoxicity). Peer-reviewed studies, published in English, investigating total joint arthroplasty devices and cytotoxic effects of PEEK particulates were included. Studies investigating devices without articulating bearings (eg, spinal instrumentation devices) and bulk material or contact cytotoxicity were excluded. Of 129 studies, 15 were selected for analysis and interpretation. No studies were found that isolated and characterized PEEK wear particles from retrieved periprosthetic human tissue samples.ResultsIn the four studies that quantified PEEK-based particles produced using hip, knee, and spinal joint replacement simulators, the mean particle size was 0.23 µm to 2.0 µm. The absolute range reported was approximately 0.01 µm to 50 µm. Rod-like carbon particulates and granular-shaped PEEK particles were identified in human tissue by histologic analysis. Ten studies, including six animal models (rat, mouse, and rabbit), three cell line experiments, and two human tissue retreival studies, investigated the biologic response to PEEK-based particles. Qualitative histologic assessments showed immunologic cell infiltration to be similar for PEEK particles when compared with UHMWPE particles in all six of the animal studies identified. However, increased inflammatory cytokine release (such as tumor necrosis factor-α) was identified in only one in vitro study, but without substantial suppression in macrophage viability. Only one study tested the effects of par...

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“…) or per intervertebral disc for Total Disc Prostheses (TDP) with PEEK/PEEK contact (a adapted from Ref. and b from Ref. )…”

Section: Discussionmentioning

confidence: 99%

Tribology of flexible and sliding spinal implants: Development of experimental and numerical models

et al. 2016

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New fusionless devices are being developed to get over the limits of actual spinal surgical treatment, based on arthrodesis. However, due to their recentness, no standards exist to test and validate those devices, especially concerning the wear. A new tribological first approach to the definition of an in vitro wear protocol to study wear of flexible and sliding spinal devices is presented in this article, and was applied to a new concept. A simplified synthetic spine portion (polyethylene) was developed to reproduce a simple supra-physiological spinal flexion (10° between two vertebrae). The device studied with this protocol was tested in wet environment until 1 million cycles (Mc). We obtained an encouraging estimated wear volume of same order of magnitude compared to similar devices. An associated finite element (FE) numerical model has permitted to access contact information and study the effect of misalignment of one screw. First results could point out how to improve the design and suggest that a vertical misalignment of a screw (under or over-screwing) has more impact than a horizontal one. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 104-111, 2018.

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A tribological assessment of a PEEK based self-mating total cervical disc replacement

Cited by 45 publications

References 25 publications

The evolution of polymer wear debris from total disc arthroplasty

The evolution of polymer wear debris from total disc arthroplasty

The Biologic Response to Polyetheretherketone (PEEK) Wear Particles in Total Joint Replacement: A Systematic Review

Tribology of flexible and sliding spinal implants: Development of experimental and numerical models

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