A tripartite view of the posterior cingulate cortex

Foster, Brett L.; Koslov, Seth; Aponik-Gremillion, Lyndsey; Monko, Megan E.; Hayden, Benjamin Y.; Heilbronner, Sarah R.

doi:10.1038/s41583-022-00661-x

Cited by 56 publications

(52 citation statements)

References 255 publications

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“…While early functional connectivity research labelled the entire MPC as part of the 'default mode network' 22 , subsequent work has instead separated recognition responsive regions of the MPC as falling within a distinct cognitive control 23,24 or parietal memory 25 network. This fractionation is consistent with the heterogenous anatomy of MPC 26,27 , which is comprised of multiple subregions, specifically the precuneus (PrC), posterior cingulate cortex (PCC), and retrosplenial cortex (RSC), that have variably been implicated in executive and episodic cognitive functions 17 (Figure 1b). Together, a growing literature suggests that the observed dissociation of MPC responses during different types of episodic memory tasks may be better understood by considering the distinct types of mnemonic demands they require.…”

Section: Introductionsupporting

confidence: 76%

“…Of these regions, the medial parietal cortex (MPC; Figure 1a) is of particular interest given that it is routinely observed in neuroimaging studies of episodic memory retrieval 7–12 , demonstrates larger magnitude responses with increasing memory strength 13,14 , and displays strong anatomical connectivity with MTL structures 15,16 . However, despite the ubiquitous observation of MPC activity during episodic retrieval, little is known about this region’s unique contributions to mnemonic processing and therefore its role in cognition more broadly 17 . Traditionally, investigators have used tasks requiring the recall of autobiographical events, or more commonly, laboratory-based tasks of studied item recognition, to experimentally probe episodic memory 18,19 .…”

Section: Introductionmentioning

confidence: 99%

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Dissociable contributions of the medial parietal cortex to recognition memory

Koslov,

Kable,

Foster

2023

Preprint

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Human neuroimaging studies of episodic memory retrieval routinely observe the engagement of specific cortical regions beyond the medial temporal lobe. Of these, medial parietal cortex (MPC) is of particular interest given its ubiquitous, and yet distinct, functional characteristics during different types of retrieval tasks. Specifically, while recognition memory and autobiographical recall tasks are both used to probe episodic retrieval, these paradigms consistently drive distinct patterns of response within MPC. This dissociation adds to growing evidence suggesting a common principle of functional organization across memory related brain structures, specifically regarding the control or content demands of memory-based decisions. To carefully examine this putative organization, we used a high-resolution fMRI dataset collected at ultra-high field (7T) while subjects performed thousands of recognition-memory trials to identify MPC regions responsive to recognition-decisions or semantic content of stimuli within and across individuals. We observed interleaving, though distinct, functional subregions of MPC where responses were sensitive to either recognition decisions or the semantic representation of stimuli, but rarely both. In addition, this functional dissociation within MPC was further accentuated by distinct profiles of connectivity bias with the hippocampus during task and rest. Finally, we show that recent observations of person and place selectivity within MPC reflect category specific responses from within identified semantic regions that are sensitive to mnemonic demands. Together, these data better account for how distinct patterns of MPC responses can occur as a result of task demands during episodic retrieval and may reflect a common principle of organization throughout hippocampal-neocortical memory systems.Significance statementMedial parietal cortex (MPC) plays a growing role in contemporary theories of episodic memory, as it is reliably observed in human neuroimaging to be engaged during tasks of recognition and retrieval. However, the spatial pattern of MPC engagement consistently differs across these putatively similar episodic memory tasks. Despite a large literature indicating that the MPC is important for episodic memory, there is little consensus about its specific role. Here, we employed ‘precision-neuroimaging’ to identify dissociable interleaving MPC subregions, where activity reflected either memory-based decision-making or stimulus content. This dissociation within MPC provides a better understanding for how retrieval demands shape response patterns and speaks to growing evidence for a common principle of organization across memory structures of the human brain.

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Section: Introductionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Dissociable contributions of the medial parietal cortex to recognition memory

Koslov,

Kable,

Foster

2023

Preprint

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“…1b). Next, we manually defined sulci in precuneal (PrC) and posterior cingulate cortices (PCC) -which are subregions of the PMC 20,39,47 -in all human and chimpanzee brains ( Materials and Methods for a detailed description of these sulci). All PMC sulci were defined on cortical reconstructions from FreeSurfer (v6.0.0, surfer.nmr.mgh.harvard.edu; Fig.…”

Section: Chimpanzeesmentioning

confidence: 99%

“…The sulcal organization of PMC has been under-documented, even in the most recent neuroanatomical treatises (e.g., 40,41 ). Nevertheless, PMC is critically important in hominoids as it contains regions implicated in the default mode and cognitive control networks [42][43][44][45][46][47] with complex structural and functional connections 39,44,47,48 . PMC is also implicated in many complex cognitive abilities 43,47,[49][50][51][52] and is particularly susceptible to neurodegenerative disease 50 .…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, PMC is critically important in hominoids as it contains regions implicated in the default mode and cognitive control networks [42][43][44][45][46][47] with complex structural and functional connections 39,44,47,48 . PMC is also implicated in many complex cognitive abilities 43,47,[49][50][51][52] and is particularly susceptible to neurodegenerative disease 50 . Thus, quantifying the similarities and differences in the PMC sulcal patterning between chimpanzees and humans will not only shed light on the comparative neuroanatomy of PMC between species, but also provide understanding regarding structural-functional relationships between species with potential cognitive insights 53 .…”

Section: Introductionmentioning

confidence: 99%

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Sulcal morphology of posteromedial cortex substantially differs between humans and chimpanzees

Willbrand

Maboudian

Kelly

et al. 2023

Preprint

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Recent studies identify a surprising coupling between evolutionarily new sulci and the functional organization of human posteromedial cortex (PMC). Yet, no study has compared this modern PMC sulcal patterning between humans and non-human hominoids. To fill this gap in knowledge, we first manually defined 918 sulci in 120 chimpanzee (Pan Troglodytes) hemispheres and 1619 sulci in 144 human hemispheres. We uncovered four new PMC sulci, and quantitatively identified species differences in incidence, depth, and surface area. Interestingly, some PMC sulci are more common in humans and others, in chimpanzees. Further, we found that the prominent marginal ramus of the cingulate sulcus differs significantly between species. Contrary to classic observations, the present results reveal that the surface anatomy of PMC substantially differs between humans and chimpanzees, findings which lay a foundation for better understanding the evolution of neuroanatomical-functional and neuroanatomical-behavioral relationships in this highly expanded region of the human cerebral cortex.

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Neural substrates of affective temperaments: An intersubject representational similarity analysis to resting‐state functional magnetic resonance imaging in nonclinical subjects

Qiu,

Wu,

Liu

et al. 2024

Human Brain Mapping

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Previous research has suggested that certain types of the affective temperament, including depressive, cyclothymic, hyperthymic, irritable, and anxious, are subclinical manifestations and precursors of mental disorders. However, the neural mechanisms that underlie these temperaments are not fully understood. The aim of this study was to identify the brain regions associated with different affective temperaments. We collected the resting‐state functional magnetic resonance imaging (fMRI) data from 211 healthy adults and evaluated their affective temperaments using the Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire. We used intersubject representational similarity analysis to identify brain regions associated with each affective temperament. Brain regions associated with each affective temperament were detected. These regions included the prefrontal cortex, anterior cingulate cortex (ACC), precuneus, amygdala, thalami, hippocampus, and visual areas. The ACC, lingual gyri, and precuneus showed similar activity across several affective temperaments. The similarity in related brain regions was high among the cyclothymic, irritable, and anxious temperaments, and low between hyperthymic and the other affective temperaments. These findings may advance our understanding of the neural mechanisms underlying affective temperaments and their potential relationship to mental disorders and may have potential implications for personalized treatment strategies for mood disorders.

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A tripartite view of the posterior cingulate cortex

Cited by 56 publications

References 255 publications

Dissociable contributions of the medial parietal cortex to recognition memory

Dissociable contributions of the medial parietal cortex to recognition memory

Sulcal morphology of posteromedial cortex substantially differs between humans and chimpanzees

Neural substrates of affective temperaments: An intersubject representational similarity analysis to resting‐state functional magnetic resonance imaging in nonclinical subjects

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