A triple-network organization for the mouse brain

Mandino, Francesca; Vrooman, Roël M.; Foo, Heidi; Yeow, Ling Yun; Bolton, T. B.; Salvan, Piergiorgio; Teoh, Chai Lean; Lee, Chun Yao; Beauchamp, Antoine; Luo, Sarah Xinwei; Bi, Renzhe; Zhang, Jiayi; Lim, Guan; Low, Nathaniel; Sallet, Jérôme; Gigg, John; Lerch, Jason P.; Mars, Rogier B.; Olivo, Malini; Fu, Yang Ming; Grandjean, Joanes

doi:10.1038/s41380-021-01298-5

Cited by 64 publications

(92 citation statements)

References 53 publications

(84 reference statements)

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“…S8, A and B). Given the putative causal control of the anterior insular cortex (AI) on the Frontal module of the DMN (26,53), we also examined the effects of LC-NE activation on their FC changes and found that CNO-evoked activation significantly enhanced anticorrelation between AI and DMN frontal module (fig. S8, C and D).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, systemic administration of these agents indiscriminately targets all NE-producing neurons in the brain and sympathetic nervous system, making it difficult determine the role of the LC-NE in modulating the DMN. Though selective manipulation of LC-NE while imaging DMN is currently impossible in humans due to technical and ethical constraints (7,19), such studies are feasible in rodent models since structural and functional homologs of the human DMN have been identified in mice (20)(21)(22)(23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

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Chemogenetic Stimulation of Tonic Locus Coeruleus Activity Strengthens the Default Mode Network

Oyarzabal

Hsu

Das

et al. 2021

Preprint

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The default mode network (DMN) of the brain is involved in cognition, emotion regulation, impulsivity, and balancing between internally and externally focused states. DMN dysregulation has been implicated in several neurological and neuropsychiatric disorders. In this study, we used functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and spectral fiber-photometry to investigate the selective neuromodulatory effect of norepinephrine (NE)-releasing noradrenergic neurons in the locus coeruleus (LC) on the DMN in mice. Chemogenetic-induced tonic LC-NE activity decreased cerebral blood volume (CBV) and glucose uptake, and increased synchronous low frequency fMRI activity within the frontal cortices of the DMN. Fiber-photometry results corroborated these findings, showing that LC-NE activation induced NE release, enhanced calcium-weighted neuronal spiking, and reduced CBV in the anterior cingulate cortex. These data suggest that LC-NE alters conventional stimulus-evoked coupling between neuronal activity and CBV in the frontal DMN. We also demonstrated that chemogenetic activation of LC-NE neurons strengthened functional connectivity within the frontal DMN, and this effect was causally mediated by reduced modulatory inputs from retrosplenial and hippocampal regions to the association cortices of the DMN.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemogenetic Stimulation of Tonic Locus Coeruleus Activity Strengthens the Default Mode Network

Oyarzabal

Hsu

Das

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Additionally, the rat salience network converged by functional and structural connectivity as is reported in Tsai et al (2020) is also included. For mice RSNs, brain regions that are commonly found in Sforazzini et al (2014) and Mandino et al (2021) for DMN and for salience network are included in the table. For other areas, the homologous networks defined in Zerbi et al (2015) are used.…”

Section: Time-averaged Features Of Resting-state Functional Magnetic ...mentioning

confidence: 99%

“…For other areas, the homologous networks defined in Zerbi et al (2015) are used. Finally, the lateral cortical network (LCN), which is postulated to perform the central executive function in rodents, is also included for rats ( Schwarz et al, 2013 ) and for mice ( Mandino et al, 2021 ). Note that the LCN is essentially the same as the somatosensory/motor areas for rodents ( Grandjean et al, 2020 ).…”

Section: Time-averaged Features Of Resting-state Functional Magnetic ...mentioning

confidence: 99%

Functional Connectivity of the Brain Across Rodents and Humans

LaGrow

Anumba

et al. 2022

Front. Neurosci.

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Resting-state functional magnetic resonance imaging (rs-fMRI), which measures the spontaneous fluctuations in the blood oxygen level-dependent (BOLD) signal, is increasingly utilized for the investigation of the brain’s physiological and pathological functional activity. Rodents, as a typical animal model in neuroscience, play an important role in the studies that examine the neuronal processes that underpin the spontaneous fluctuations in the BOLD signal and the functional connectivity that results. Translating this knowledge from rodents to humans requires a basic knowledge of the similarities and differences across species in terms of both the BOLD signal fluctuations and the resulting functional connectivity. This review begins by examining similarities and differences in anatomical features, acquisition parameters, and preprocessing techniques, as factors that contribute to functional connectivity. Homologous functional networks are compared across species, and aspects of the BOLD fluctuations such as the topography of the global signal and the relationship between structural and functional connectivity are examined. Time-varying features of functional connectivity, obtained by sliding windowed approaches, quasi-periodic patterns, and coactivation patterns, are compared across species. Applications demonstrating the use of rs-fMRI as a translational tool for cross-species analysis are discussed, with an emphasis on neurological and psychiatric disorders. Finally, open questions are presented to encapsulate the future direction of the field.

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“…These regions are part of the so-called Salience Network (SN) and are highly responsive to arousing situations in humans (Hermans et al, 2014b) and in mice (Mandino et al, 2021;Zerbi et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Remote contextual fear retrieval engages activity from salience network regions in rats

Corrêa

Grisanti

Franciscatto

et al. 2021

Preprint

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The ability to retrieve contextual fear memories depends on the coordinated activation of a brain-wide circuitry. Transition from recent to remote memories seems to involve the reorganization of this circuitry, a process called systems consolidation that has been associated with time-dependent fear generalization. However, it is not known whether emotional memories acquired under different levels of stress can undergo different systems consolidation processes. Here, we explored the activation pattern and functional connectivity of key brain regions associated with contextual fear conditioning (CFC) retrieval after recent (2 days) or remote (28 days) memory tests performed in rats submitted to strong (1.0mA footshock) or mild (0.3mA footshock) training. We used brain tissue from Wistar rats from a previous study, where we observed that increasing training intensity promotes fear memory generalization over time, possibly due to an increase in corticosterone levels during memory consolidation. Analysis of Fos expression across 8 regions of interest (ROIs) allowed us to identify coactivation between them at both timepoints following memory recall. Our results showed that strong CFC elicits higher Fos activation in the anterior insular and prelimbic cortices during remote retrieval, which was - along with the basolateral amygdala - positively correlated with freezing. Rats trained either with mild or strong CFC showed a broad functional connectivity at the recent timepoint whereas only animals submitted to the strong CFC showed a widespread loss of coactivation during remote retrieval. Our findings suggest that increasing training intensity results in differential processes of systems consolidation, possibly associated with increased post-training corticosterone release, and that strong CFC engages activity from areas associated with the salience network during remote retrieval.

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A triple-network organization for the mouse brain

Cited by 64 publications

References 53 publications

Chemogenetic Stimulation of Tonic Locus Coeruleus Activity Strengthens the Default Mode Network

Chemogenetic Stimulation of Tonic Locus Coeruleus Activity Strengthens the Default Mode Network

Functional Connectivity of the Brain Across Rodents and Humans

Remote contextual fear retrieval engages activity from salience network regions in rats

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