A ‘turn-on’ fluorescent chemosensor for the detection of Zn²⁺ ion based on 2-(quinolin-2-yl)quinazolin-4(3H)-one

Abstract

Abstract2-(Quinolin-2-yl)quinazolin-4(3H)-one (Q) was synthesized via the Brønsted acid-promoted tandem cyclization/dehydrogenation reaction with a good yield. Compound Q is a selective ‘turn-on’ fluorescent sensor for Zn2+ ion without interference by Cd2+. The 1:1 binding model of Q to Zn2+ was confirmed by the Benesi-Hildebrand analysis, Job’s plot analysis and a ultraviolet-visible (UV-Vis) titration experiment. Furthermore, the light-on fluorescent response can be observed by the naked eye under UV-lamp irradiation (365 nm).

Cellphone-Aided Attomolar Zinc Ion Detection Using Silkworm Protein-Based Nanointerface Engineering in a Plasmon-Coupled Dequenched Emission Platform

“…In this background, several techniques have been developed for the detection of Zn 2+ ions. − However, the proposed methodologies involve the use of harmful elements or high-end techniques that are experimentally not feasible in a resource-limited setting. Also, the limit of detection that is achieved so far has been in the nanomolar concentration range. , …”

“…cavity nanointerface using ARS as the fluorescent probe. The strong and selective interaction of Zn 2+ ions with ARS results in shift of the absorbance maximum of ARS from ∼400 to ∼510 nm upon Zn 2+ ion addition. − We have utilized this understanding to detect Zn 2+ ions by excitation at 532 nm in the SPCE platform. The zinc ions and ARS are mixed together and then doped in the PVA matrix and spin-coated as a single layer on the Ag thin film.…”

Zn2+ detection of a benzimidazole 8-aminoquinoline fluorescent sensor by inhibited tautomerization

“…Numerous fluorescent chemosensors for Zn 2+ -sensing have been designed over the past decades. 7,8 Among many trace metal ion sensors, quinoline is a common fluorophore used as a backbone in zinc sensing structures. 9,10 The application of various 8-hydroxyquinolates in the fluorometric detection of zinc dates back as far as the 1960s.…”

Design, Synthesis And Evaluation Of New Chemosensors Containing Quinazolinones Moiety For Ions In An Aqueous Medium And Biological Samples

“…Synthesized azo dye-based heterocyclic chemosensors to produce fluorescent sensors for the detection of zinc without interference with cadmium. 35 Ailin Yuan et al :(2013) synthesis of novel quinazolinone compound as a fluorescence sensor for the ferric ion. 36 Quinazolinone and its derivatives have widespread medical treatments, for instance, antibacterial, anti-fungal, anti-HIV, and antitumor.…”