A “turn-on” Michler's ketone–benzimidazole fluorescent probe for selective detection of serum albumins

Abstract

Enhanced emission and selective binding with albumins.

Functional α-Cyanostilbenes: Sensing to Imaging

“…Competitive binding studies showed that the probe selectively binds to albumin proteins over other substances commonly found in serum. Cellular imaging studies reveal localization in the cytoplasm, and serum depletion studies show a reduction in fluorescence intensity, indicating the probe's binding affinity to albumins 48 .…”

“…Cellular imaging studies reveal localization in the cytoplasm, and serum depletion studies show a reduction in fluorescence intensity, indicating the probe’s binding affinity to albumins. 48…”

“…The coumarin pyridinium scaffold 59 and 60 , with a nitrile group on the double bond, was utilized by our group to detect sulfite through a Michael addition reaction. 49 The molecules are characterized by strong donor moieties, N , N -diethylamine, or Julolidine groups, with a pyridinium acceptor. With an emission at 646 nm for 59 and 673 nm for 60 , the fluorophores showed emission quenching upon the addition of sulfite, with the formation of new absorption and emission bands, with a limit of detection of 1.47 μM and 2.8 μM, respectively.…”

Probing the Interactions Between Anthanthrene Derivatives and Bovine Serum Albumin (BSA) Through Aggregation Induced Emission

“…Elegant examples based on small molecules illustrating not only the significant fluorescence sensing performance towards albumins but also the photostability, fluorescence quantum yields and fine-tuning the emission wavelengths to NIR region have been reported. [20][21][22][23][24][25] In parallel, the use of organic dye molecules such as functionalized squiraine, [26][27][28][29] cyanine, [30] fluorescein, [31] BODIPY dyes, [32,33] and others [34,35] have proven to be highly efficient for the detection and quantification of protein samples. Certainly, these BSA-dye interactions are useful for developing fluorescent markers, [29,36,37] protein assays, [31] and monitoring protease activity, [38] biophosphors, [39] solid-sate lightening (SSL) based on biomaterials, [40] and understanding the pharmacokinetics of albumin-based drug delivery systems.…”

Differential detection of strong acids in weak acids: a combination of a benzimidazole-carbazole backbone with AIE luminophores as highly sensitive and selective turn-on fluorescent probes

“…Accordingly, stimuli-responsive turn-on fluorescent probes that can offer an easy and intuitive detection way with the naked eye directly are highly desired. [32][33][34][35] The user can quickly judge within an established detection range by the direct and time-saving lighton mechanism which is more in line with the industrial requirement.…”