A twin study of genetic and environmental influences on suicidality in men

Fu, Qiang; Heath, Andrew C.; Bucholz, K. K.; Nelson, E. C.; Glowinski, Anne L.; Goldberg, Joel; Lyons, Michael J.; Tsuang, Ming T.; Jacob, Theodore; True, M. R.; Eisen, Seth A.

doi:10.1017/s0033291701004846

Cited by 218 publications

(176 citation statements)

References 49 publications

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“…4,[18][19][20] Employment and marital status have been shown to be associated with SI, with unemployed and unmarried people being significantly more likely to have SI. 6,21 While the prevalence rates of completed suicides appear to indicate that younger adults are at greater risk of death by suicide, there are some inconsistencies in the data, with several trials finding younger people more likely to have SI, 19,22 and at least one study failing to find an association between age and SI. 13 Studies attempting to relate education level to SI have also been inconclusive.…”

Section: S Erious Si Is Not Uncommon In the General Populationmentioning

confidence: 99%

“…13 Studies attempting to relate education level to SI have also been inconclusive. 6,19,21 Additionally, a low level of social and occupational functioning, and poor perceived social support, may also be independent risk factors for SI. 5,23 SI and behaviour, collectively referred to as suicidality, is often measured along a continuum, ranging from passive thoughts that life is not worth living, to fleeting ideas of death or suicide with no intention of inflicting harm, to active SI and behaviour accompanied by a genuine intent to inflict harm.…”

Section: S Erious Si Is Not Uncommon In the General Populationmentioning

confidence: 99%

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Clinical and Sociodemographic Characteristics Associated with Suicidal Ideation in Depressed Outpatients

et al. 2013

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Objective: To identify clinical and sociodemographic characteristics associated with suicidal ideation (SI) among patients seeking care for depression in routine primary and psychiatric care settings. Methods:We examined data from 4041 treatment-seeking outpatients with major depressive disorder (MDD) to compare baseline sociodemographic and clinical characteristics of those with and without SI, and the presence or absence of baseline depressive symptoms and psychiatric comorbidities in those with SI.Results: SI was significantly (P < 0.01) associated with numerous sociodemographic characteristics (that is, lower level of education, Caucasian or African American, male, unemployed, and treated in psychiatric care) and clinical features (that is, previous suicide attempt, younger age of MDD onset, greater baseline depressive symptom severity, greater number of depressive symptoms, and presence of agoraphobia and [or] generalized anxiety disorder). Elevated levels of SI at baseline were associated with decreased remission rates.Conclusions: Consistent with past findings, increased rates of SI were associated with greater depressive symptom severity as well as other features suggestive of severity of illness. Our results confirm previous findings of associations between SI and panic and (or) phobic symptoms and anxiety, but did not confirm previous findings of an association between SI and alcohol or drug use and (or) dependence. While selective serotonin reuptake inhibitor monotherapy appeared significantly helpful in reducing SI during the course of treatment, the presence of SI at baseline was found to be a associated with decreased treatment response, with patients reporting SI at the start of treatment being less likely to achieve remission.

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Section: S Erious Si Is Not Uncommon In the General Populationmentioning

confidence: 99%

Section: S Erious Si Is Not Uncommon In the General Populationmentioning

confidence: 99%

Clinical and Sociodemographic Characteristics Associated with Suicidal Ideation in Depressed Outpatients

et al. 2013

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“…However, in a 5 year follow-up of alcoholics, clinical risk factors accounted for less than half of the variance for suicidal behavior, whereas genetic-epidemiologic studies indicate that up to half of the variance for attempting suicide is owing to genetic factors (Preuss et al, 2003;Statham et al, 1998;Glowinski et al, 2001;Fu et al, 2002). As low central serotonin function is implicated in suicidal behavior, we examine here the possible role of the serotonin transporter gene in suicidal behavior among substance dependent patients (Asberg, 1997).…”

Section: Introductionmentioning

confidence: 99%

Interaction between Childhood Trauma and Serotonin Transporter Gene Variation in Suicide

Roy

Janal³

et al. 2007

Neuropsychopharmacol

178

115

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Although the serotonin transporter promoter polymorphism (5-HTTLPR) contributes to depression and suicidality in a fashion modulated by environmental stress, 5-HTTLPR has been little examined in relation to suicidal behavior in substance dependence. Recently, a third functional allele of 5-HTTLPR was discovered enabling more of the interindividual variation in serotonin transporter expression to be predicted by genotype. We examined whether the 5-HTTLPR gene alone, or interacting with childhood trauma, was predictive of suicidal behavior in substance-dependent patients, a clinical population that is at high risk of suicide, as well as childhood trauma and other stress. We interviewed 306 abstinent male African-American substance-dependent patients about whether they had ever attempted suicide and administered the 34-item Childhood Trauma Questionnaire (CTQ). Patients and 132 male African-American controls were genotyped to determine the S, L G , and L A 5-HTTLPR alleles; some analyses grouped the S and L G alleles on the basis of equivalent function. The distribution of 5-HTTLPR genotypes did not differ between patients and controls, nor between suicide attempters and nonattempters. However, patients with low expression 5-HTTLPR genotypes and above-median CTQ scores were more likely to have attempted suicide. Logistic regression showed increasing risk of a suicide attempt with increasing reports of childhood trauma scores; in addition, this increase was exaggerated among those with low expression forms of the 5-HTTLPR genotype. Childhood trauma interacts with low expressing 5-HTTLPR genotypes to increase the risk of suicidal behavior among patients with substance dependence.

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“…Kim et al (2005) observaron que los familiares de los suicidas presentaron hasta 10 veces mayor riesgo de suicidio y atentados suicidas, que en el grupo control. Este riesgo familiar se ha mostrado en diversos trabajos (Brezo et al, 2008;Fu et al, 2002;Kim et al, 2005), destaca un estudio realizado en población sueca, en individuos que fueron hospitalizados por presentar intentos de suicidio entre 1968y 1980(Mittendorfer-Rutz, Rasmussen, & Wasserman, 2008, y observaron que el riesgo de suicidio aumenta entre familiares con intentos suicidas este se presenta a edad temprana principalmente en el género masculino.…”

Section: Neurobiología De La Conducta Suicidaunclassified

“…Baldessarini & Hennen, (2004) reportaron que los gemelos monocigotos presentan un riesgo 17 veces mayor a presentar conducta suicida que los gemelos dicigotos. Otros estudios estiman una heredabilidad del 17 al 55% para intentos de suicidio y un 20% para el suicidio consumado (Fu et al, 2002;Roy, Segal, Centerwall, & Robinette, 1991;Statham et al, 1998).…”

Section: Estudios En Gemelosunclassified

Genes, the serotonergic system and suicidal behavior

Tovilla‐Zárate

Mendoza

2012

Int. j. psychol. res.

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The study of suicidal behavior has gained relevance given that recently about 50% of the population between 14 and 19 years old exhibit suicidal ideation and, in the population in general, there has been a rise of up to 150% in suicidal behavior. The outcomes of these studies of genetic epidemiology show that several genes may be associated with suicidal behavior. In particular, one of the hypotheses propounds that genes of proteins that participate in the serotonergic pathway could be responsible for the development of this behavior. There is neurochemical evidence showing alterations at different levels along this pathway. In this work, a review is made of several of the genes participating in the serotonergic pathway and their possible participation in suicidal behavior.Key Words: Suicide; serotonin; genetics; polymorphism; association studies . RESUMENLa conducta suicida es un problema de salud mental en el mundo. El estudio de la conducta suicida toma interés dado que en los años recientes, cerca del 50% de la población entre 14 y 19 años de edad presentan ideación suicida y en la población general se observa un aumento hasta del 150% en la conducta suicida. Estudios de epidemiología genética muestran que los genes pueden estar asociados a la conducta suicida. Recientemente se ha propuesto que los genes involucrados en la llamada vía serotoninérgica están participando, ya que evidencia neuroquímica demuestran alteraciones a diferentes niveles. Sin embargo, en población latina son pocos los estudios que evalúen el papel de los genes para generar estas condiciones. En este trabajo, se presenta una revisión de los principales genes que participan en la vía serotoninérgica y presenta evidencia de la participación de esos en la conducta suicida.Palabras Clave: Suicidio, Serotonina, Genética, polimorfismos, Estudios de asociación . ________________________ Recibido

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A twin study of genetic and environmental influences on suicidality in men

Abstract: There may be a genetic susceptibility specific to both suicidal ideation and suicide attempt in men, which is not explained by the inheritance of common psychiatric disorders.

Cited by 218 publications

References 49 publications

Clinical and Sociodemographic Characteristics Associated with Suicidal Ideation in Depressed Outpatients

Clinical and Sociodemographic Characteristics Associated with Suicidal Ideation in Depressed Outpatients

Interaction between Childhood Trauma and Serotonin Transporter Gene Variation in Suicide

Genes, the serotonergic system and suicidal behavior

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