A two fatal cases of poisoning involving new cathinone derivative PV8

Pieprzyca, Ewelina; Skowronek, Rafał; Korczyńska, Małgorzata; Kulikowska, Joanna; Chowaniec, Małgorzata

doi:10.1016/j.legalmed.2018.05.002

Cited by 18 publications

(7 citation statements)

References 12 publications

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“…Future improvement of the method used in this study should include the so-called new psychoactive substances, such as cathinones, phenethylamines and synthetic opioids, which have been involved in recent intoxication cases in Brazil and elsewhere. 35,36…”

Section: Resultsmentioning

confidence: 99%

Drugs, pesticides and metabolites in forensic post-mortem blood samples

Júnior

Santos²,

Caldas

2020

Med Sci Law

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Forensic post-mortem toxicological data provide valuable information for the elucidation of cause of death. However, this is still not routine practice in Brazilian laboratories. This study investigated the presence of illicit and prescription drugs, pesticides and metabolites in 111 post-mortem blood samples from cases investigated by the Forensic Medical Institute of the Federal District, Brazil. Quantitative analysis was performed for 14 analytes using a validated programmed temperature vaporisation-large volume injection-gas chromatography–mass spectrometry method, which was also used as screening (qualitative analysis) for an additional 19 substances of forensic interest. At least one analyte was found in 61.2% of the samples, of which 34 were related to homicide, 15 to accidental death and 10 to suicide cases. The victims were 14–72 years old. The benzodiazepines diazepam, midazolam and 7-aminoflunitrazepan were detected in 46% of the positive samples (0.02–1.12 µg/mL; midazolam only qualitative). Cocaine was found in 34% (0.02–4.07 µg/mL), associated with substances commonly used as cocaine adulterants (e.g. caffeine, lidocaine and phenacetin). Three suicide cases involved the illegal rodenticide chumbinho, residues of which were found in the gastric content, and blood samples showed the presence of terbufos (0.03 and 0.04 µg/mL) and carbofuran (27.3 µg/mL). These results are discussed, along with autopsy and crime-scene information.

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Section: Resultsmentioning

confidence: 99%

Drugs, pesticides and metabolites in forensic post-mortem blood samples

Júnior

Santos²,

Caldas

2020

Med Sci Law

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“…The analytes were isolated from the matrix by acetonitrile precipitation as well as extraction with ethyl acetate. The exact test procedure was published together with the detailed description of two cases of intoxication with the PV8 SC ( 8 ).…”

Section: Methodsmentioning

confidence: 99%

Toxicological Analysis of Intoxications with Synthetic Cathinones

Pieprzyca

Skowronek

Czekaj

2021

Journal of Analytical Toxicology

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Synthetic cathinones (SCs) are currently the second largest and the second most frequently seized group of new psychoactive substances. They are sold as replacements for controlled stimulants such as amphetamine, cocaine and MDMA. Administration of low doses of SCs can cause euphoria and increased alertness, and administration of high doses or chronic use of cathinones can cause serious adverse effects, such as hallucinations, delirium, hyperthermia, and tachycardia. In the years 2013–2019 in our practice, as many as 16 different SCs were detected in biological materials. Presented article lists the observed concentrations in 39 fatal and 18 non-fatal cases, in which a single SC as well as an SC in combination with amphetamine or ethyl alcohol were detected and quantified in biological materials. The quantitative analyses were carried out by LC-MS/MS. The analysed cases of taking SCs were associated with intoxication (2 cases), fatal intoxication (36), driving under the influence of drugs (10), and other circumstances (9), such as violence, insulting an officer, and holding a hostage. Taking SCs has serious side effects that can lead to multiple organ failure and death. Screening for the presence of SCs in biological materials should be part of the routine course of treatment in intoxication cases, both at the stage of clinical diagnosis and at the stage of forensic toxicological analysis. Ethyl alcohol and amphetamine may contribute to increased SC toxicity. This data could be valuable for further interpretation of other results from toxicological analyses.

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“…MDPV8, first identified in 2019, is an analog of other popular synthetic cathinones; PV8 (1-phenyl-2-(pyrrolidin-1-yl)-heptan-1-one) [ 102 , 103 ], and MDPHP (1-(1,3-benzodioxol-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one) distinguished from them by the presence of a 3,4-methylenedioxy moiety, and by elongated alkyl side chain respectively (Fig. 5 ).…”

Section: Chemistrymentioning

confidence: 99%

A review of synthetic cathinones emerging in recent years (2019–2022)

Kuropka¹,

Zawadzki

Szpot

2022

Forensic Toxicol

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Purpose The emergence of novel psychoactive substances (NPS) has been being a continuous and evolving problem for more than a decade. Every year, dozens of new, previously unknown drugs appear on the illegal market, posing a significant threat to the health and lives of their users. Synthetic cathinones are one of the most numerous and widespread groups among NPS. The purpose of this work was to identify and summarize available data on newly emerging cathinones in very recent years. Methods Various online databases such as PubMed, Google Scholar, but also databases of government agencies including those involved in early warning systems, were used in search of reports on the identification of newly emerging synthetic cathinones. In addition, threads on various forums created by users of these drugs were searched for reports on the effects of these new substances. Results We have identified 29 synthetic cathinones that have been detected for the first time from early 2019 to mid-2022. We described their structures, known intoxication symptoms, detected concentrations in biological material in poisoning cases, as well as the countries and dates of their first appearance. Due to the lack of studies on the properties of the novel compounds, we compared data on the pharmacological profiles of the better-known synthetic cathinones with available information on the newly emerged ones. Some of these new agents already posed a threat, as the first cases of poisonings, including fatal ones, have been reported. Conclusions Most of the newly developed synthetic cathinones can be seen as analogs and replacements for once-popular compounds that have been declining in popularity as a result of legislative efforts. Although it appears that some of the newly emerging cathinones are not widely used, they may become more popular in the future and could become a significant threat to health and life. Therefore, it is important to continue developing early warning systems and identifying new compounds so that their widespread can be prevented.

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A two fatal cases of poisoning involving new cathinone derivative PV8

Cited by 18 publications

References 12 publications

Drugs, pesticides and metabolites in forensic post-mortem blood samples

Drugs, pesticides and metabolites in forensic post-mortem blood samples

Toxicological Analysis of Intoxications with Synthetic Cathinones

A review of synthetic cathinones emerging in recent years (2019–2022)

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