“…Compared with the flexible 25-gauge instruments, the stiffer and larger 23-gauge instruments allow for ocular movements to be more easily controlled and manipulations during surgery are more secure and unrestricted. 3,4 Thus, although the 25-gauge instruments are constantly improved, some vitreoretinal surgeons may prefer to perform 23-gauge TSV for complicated vitreoretinal surgery that requires thorough removal of peripheral vitreous gel and long-acting gas tamponade.Transconjunctival sutureless vitrectomy with gas tamponade requires more complete closure of sclerotomy sites because dysfunction in self-sealing could cause an early postoperative gas leakage, thus leading to decreased tamponade efficiency. It is true that postoperative intraocular pressure (IOP) is a good index of wound closure in fluid-filled eyes, but postoperative gas volume and its decreasing process would also be important indices in gas-filled eyes.…”