A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity

Howell, Amy B.; Reed, Jess D.; Krueger, Christian G.; Winterbottom, R.; Cunningham, David; Leahy, Marge

doi:10.1016/j.phytochem.2005.05.022

Cited by 440 publications

(451 citation statements)

References 19 publications

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“…Cranberry products do not inhibit bacterial growth, but inhibit bacterial adherence to uroepithelial cells, thereby reducing the development of UTI. The anti-adhesive effects of p-fimbriated UPEC to uroepithelial cells are related to A-linked PAC as compared with lack of anti-adhesion activities of B-linked PAC from grape, apple juice, green tea and chocolate (Howell et al, 2005). The A-type PAC in cranberries enhance the anti-adhesive effects in vitro and in urine.…”

Section: Vaccinium Macrocarpon (Cranberry)mentioning

confidence: 98%

Natural Approaches for Controlling Urinary Tract Infections

Amalaradjou¹,

Venkitanarayanan²

2011

Urinary Tract Infections

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Section: Vaccinium Macrocarpon (Cranberry)mentioning

confidence: 98%

Natural Approaches for Controlling Urinary Tract Infections

Amalaradjou¹,

Venkitanarayanan²

2011

Urinary Tract Infections

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“…This activity was originally believed to be due to acidification of urine, and/or increased excretion of the cranberry urinary metabolite hippuric acid [6,7], although later research suggested these effects were not significant enough to account for observed bioactivity [8,9]. Inhibition of E. coli adherence to uroepithelial cells [5,[10][11][12][13][14], rather than direct bacteriostatic or bactericidal activity, is currently believed to be the mechanism by which cranberry helps prevent and treat urinary tract infections.…”

Section: Cranberries As Antibacterial Agentsmentioning

confidence: 99%

An experimental implementation of chemical subtraction

Chen¹,

Turner²,

Jaki³

et al. 2008

Journal of Pharmaceutical and Biomedical Analysis

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A preparative analytical method was developed to selectively remove ("chemically subtract") a single compound from a complex mixture, such as a natural extract or fraction, in a single step. The proof of concept is demonstrated by the removal of pure benzoic acid (BA) from cranberry (Vaccinium macrocarpon Ait.) juice fractions that exhibit anti-adhesive effects vs. uropathogenic E. coli. Chemical subtraction of BA, representing a major constituent of the fractions, eliminates the potential in vitro interference of the bacteriostatic effect of BA on the E. coli anti-adherence action measured in bioassays. Upon BA removal, the anti-adherent activity of the fraction was fully retained, 36% inhibition of adherence in the parent fraction at 100 ug/mL increased to 58% in the BA-free active fraction. The method employs countercurrent chromatography (CCC) and operates loss-free for both the subtracted and the retained portions as only liquid-liquid partitioning is involved. While the high purity (97.47% by quantitative 1 H NMR) of the subtracted BA confirms the selectivity of the method, one minor impurity was determined to be scopoletin by HR-ESI-MS and (q)HNMR and represents the first coumarin reported from cranberries. A general concept for the selective removal of phytoconstituents by CCC is presented, which has potential broad applicability in the biological evaluation of medicinal plant extracts and complex pharmaceutical preparations.

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“…The growing of cranberry has also been initiated in Latvia, Belarus, Romania, Azerbaijan and Tunisia (Food and Agriculture Organization -FAO of the United Nations 2012). Increasing knowledge about the specific properties of cranberry fruit, their health benefits and functional values (Howell et al 2005, Howell 2009) that has been confirmed by conventional medical knowledge (Avorn et al 1994, Shmuely et al 2004, Vatten et al 2005) has induced growth in demand for cranberries. In Central European countries, the cultivation of cranberry is still at a low level.…”

Section: Introductionmentioning

confidence: 98%

Initial growth and yield structure of selected cultivars of cranberry (Vaccinium macrocarpon Ait.) cultivated on mineral soils

Szwonek¹,

Maciorowski²,

Koziński³

et al. 2016

Folia Horticulturae

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A study was conducted to evaluate the possibility of cranberry cultivation on mineral soils and to assess the influence of vegetative biomass development, generative growth and yield components on the yielding of three cranberry cultivars originating in the USA (Stevens, Pilgrim and Ben Lear) at two locations in Poland. The key biometrical traits involved in yield formation were taken into account, and the soil and plant chemical conditions were evaluated. All of the measured biometrical characteristics were strongly influenced by the location and the year of cultivation, and varietal differences were also noted. The most important determinants that explained yield variation were: the number of uprights per square meter, floral induction and berry set. However, the participation of each component in yield variation was strongly affected by the location, age of plantation and to a minor extent by the cultivar. The study confirmed the possibility of cranberry cultivation on mineral soils with a low pH. The biggest average yield of the three years was collected from cv. Stevens as cultivated on sandy soil in contrast to the same cultivar grown on sandy loam soil. In the case of sandy loam soil after acidification, cv. Pilgrim appeared to be a relatively better yielding cultivar.

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A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity

Cited by 440 publications

References 19 publications

Natural Approaches for Controlling Urinary Tract Infections

Natural Approaches for Controlling Urinary Tract Infections

An experimental implementation of chemical subtraction

Initial growth and yield structure of selected cultivars of cranberry (Vaccinium macrocarpon Ait.) cultivated on mineral soils

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