A Unique Radiologic Case of Optic Nerve Infarction in a Patient With Mucormycosis

Chaulk, Alexandria L; Thai, Hoang; Supsupin, Emilio P; Bhattacharjee, Meenakshi B.; Richani, Karina; Adesina, Ore‐Ofeoluwatomi O

doi:10.1097/wno.0000000000001179

Cited by 8 publications

(14 citation statements)

References 11 publications

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“…Prognosis is improved by surgical treatment in combination with antifungal agents. 2 14 Mucorales of the problematic genus or species appear to have little effect on results. 9 14 Mortality in previous studies was 65%.…”

Section: Discussionmentioning

confidence: 99%

“…2 14 Mucorales of the problematic genus or species appear to have little effect on results. 9 14 Mortality in previous studies was 65%. 4…”

Section: Discussionmentioning

confidence: 99%

“…In comparison to female patients, male patients have a weak immune system. 6,14,20 Steroid treatment, remdesivir, and tocolizumab were used to treat COVID-19 in 68.8, 28.6, and 16.9% of cases, respectively. Individuals with mucormycosis had the COVID-19 active form in 83.1% of studies, while 11.7% of studies reported recovered patients.…”

Section: Discussionmentioning

confidence: 99%

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Onset of Mucormycosis in Patients with COVID-19: A Systematic Review on Patients' Characteristics

Ghasemi

Dashti²,

Fahimipour

et al. 2022

Eur J Dent

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Mucormycosis has a significant impact on patients' standard of living and, therefore, a high clinical suspicion, prediagnosis, and rapid treatment are critical in easing patients' suffering and fast recovery. Our focus is to conduct an organized review based on various variables on the patients' characteristics having mucormycosis in severe novel coronavirus disease 2019 (COVID-19). We examined Embase, PubMed-Medline, LitCovid, Web of Science, Scopus, and the reference lists of included case reports up to September 20, 2021, using the Medical Subject Heading (MeSH) phrases and other keywords related to this topic. Subsequently, we investigated associated comorbidities, patient characteristics, position of mucormycosis, steroids use, body involvements, and outcomes. Overall, 77 studies were conducted and among these, 72 studies mentioned that the patients' age to be 48.13±14.33 (mean±standard deviation [SD]) years. Diabetes mellitus (DM) was reported in 77.9% (n=60) of cases. Studies showed that central nervous system (CNS) and bone involvement were reported in 62.3 (n=48) and 53.2% (n=41), respectively. More fatalities were observed in patients with mucormycosis with the active form of COVID-19. Also, men infected with mucormycosis significantly affected by COVID-19. In the end, mortality was higher in males with mucormycosis. As a result, a solid investigation into the root cause of mucormycosis, especially in COVID-19, should be included in the study plan. If the patient is COVID-19-positive and immunosuppressed, this opportunistic pathogen diagnostic test should not be overlooked.

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Section: Discussionmentioning

confidence: 99%

“…2 14 Mucorales of the problematic genus or species appear to have little effect on results. 9 14 Mortality in previous studies was 65%. 4…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Onset of Mucormycosis in Patients with COVID-19: A Systematic Review on Patients' Characteristics

Ghasemi

Dashti²,

Fahimipour

et al. 2022

Eur J Dent

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“…8). Detailed literature search yielded only few case reports of nerve abscesses involving the trigeminal and optic nerves in the pre-pandemic era with a single documented case report in CAM [16,17].…”

Section: Orbital Diseasementioning

confidence: 99%

MR imaging spectrum in COVID associated Rhino-Orbito-Cerebral mucormycosis with special emphasis on intracranial disease and impact on patient prognosis

Sehgal

Kumar

Garg

et al. 2022

European Journal of Radiology

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“…There are few rhino-orbito-cerebral mucormycosis cases in the literature with associated optic nerve ischemia [4][5][6][7][8]. There are even fewer cases of rhino-orbito-cerebral mucormycosis associated with optic nerve ischemia and ischemic neuropathy in the literature [9,10]. With the outbreak of coronavirus disease 2019 (COVID- 19), there have been reported cases of acute invasive rhino-orbito-cerebral mucormycosis in the setting of COVID-19 [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

COVID-19-Related Rhino-Orbito-Cerebral Mucormycosis Complicated by the Optic Nerve and Optic Tract Ischemia With Ischemic Neuropathy

Onyi¹,

Shin²,

Umeh³

et al. 2022

Cureus

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Mucormycosis is a life-threatening invasive fungal infection usually seen in immunocompromised patients and patients with poorly controlled diabetes mellitus with or without diabetic ketoacidosis. We present a rhino-orbito-cerebral mucormycosis (ROCM) case in a coronavirus disease 2019 (COVID-19) patient complicated by the optic nerve and optic tract ischemia with ischemic neuropathy. Both CT and MRI played an essential role in diagnosing ROCM and the accompanying complications in our patient.CT showed sinonasal sinusitis and MRI showed the sinusitis and its progression to ROCM. MRI also showed necrosis involving the bilateral orbits, basal ganglia, thalamus, internal capsule, hypothalamus, optic chiasm, optic nerves, olfactory bulbs, and skull base. ROCM associated with optic nerve ischemia is a rare but life-threatening complication of COVID-19, especially in patients with underlying diabetes and/or those treated with corticosteroids. Physicians should be aware of this complication as early diagnosis may improve the chances of survival in such patients.

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A Unique Radiologic Case of Optic Nerve Infarction in a Patient With Mucormycosis

Cited by 8 publications

References 11 publications

Onset of Mucormycosis in Patients with COVID-19: A Systematic Review on Patients' Characteristics

Onset of Mucormycosis in Patients with COVID-19: A Systematic Review on Patients' Characteristics

MR imaging spectrum in COVID associated Rhino-Orbito-Cerebral mucormycosis with special emphasis on intracranial disease and impact on patient prognosis

COVID-19-Related Rhino-Orbito-Cerebral Mucormycosis Complicated by the Optic Nerve and Optic Tract Ischemia With Ischemic Neuropathy

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