A universal strategy for the construction of polymer brush hybrid non-glutaraldehyde heart valves with robust anti-biological contamination performance and improved endothelialization potential

Comparison study of surface-initiated hydrogel coatings with distinct side-chains for improving biocompatibility of polymeric heart valves

“…27,30 Currently, numerous researchers have explored the construction of hydrogel coatings on prosthetic heart valve surfaces to meet specific requirements, including excellent biocompatibility, anti-coagulation, and anti-calcification properties. For instance, Yu et al 31 departed from the traditional method of glutaraldehyde cross-linking for bioprosthetic valves. Instead, they adopted bromo bicyclic-oxazolidine cross-linking in the porcine pericardium and introduced amphiphilic pSBMA polymer brushes through in situ ATRP.…”