A urine metabonomics study of chronic renal failure and intervention effects of total aglycone extracts of Scutellaria baicalensis in 5/6 nephrectomy rats

Abstract

This study was to clarify the pathogenesis of CRF and action mechanism of TAES.

Metabolomics study of renal fibrosis and intervention effects of total aglycone extracts of Scutellaria baicalensis in unilateral ureteral obstruction rats

“…A value of P < 0.05 was considered statistically significant. For GC/MS data, data processing，significant variables selection and identification are in accordance with our previously published work (Fang et al, 2015).…”

“…Urine sample preparation and sample analysis by GC/MS was performed in accordance with our previously published work (Fang et al, 2015).…”

“…The voucher specimens (HQRR039) were deposited in the Herbarium of Institute of Chinese Materia Medica，Shanghai University of TCM. TAES was prepared as described previously (Fang et al, 2015), and the extraction process is protected by the Chinese patent (CN 1583775A). The HPLC analysis of TAES was conducted (Fig.…”

“…), plant part: root] belonging to the Labiatae family, is a well-known TCM with the efficacy for heat-clearing, dampness-drying, fire-purging, detoxicating and maintaining hemostasis (Li, 2008). Our previous studies have demonstrated that total aglycone extracts of Scutellaria Baicalensis (TAES) can improve kidney disease in rats (Xie et al, 2009;Fang et al, 2015). However, no research has investigated the efficacy and mechanism of TAES in treating renal fibrosis induced by UUO.…”

Metabolomics insights into diabetes nephropathy and protective effects of Radix Scutellariae on rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

“…44,45 Moreover, recent research demonstrated that RS treatment regulated urinary glucose in chronic renal failure. 46 Downregulated urinary glucose level by RS treatment throughout the progress of DN implicated the potential suppressive effect of RS on SGLT1 or SGLT2. Citric acid is a major intermediate in the tricarboxylic acid (TCA) cycle.…”