A User-Friendly Software Package for HIFU Simulation

Soneson, Joshua E.

doi:10.1063/1.3131405

Cited by 96 publications

(78 citation statements)

References 5 publications

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“…Simulated acoustic pressure fields in water were obtained using the software HIFU_Simulator (Soneson, 2008), which solves the axisymmetric KZK equation for continuous wave beams using a split-step time and frequency domain algorithm on a finite difference discretization. HIFU_Simulator was also used to generate the focal acoustic pressures and temperatures in tissue against which the derating algorithm was compared.…”

Section: A Computational Designmentioning

confidence: 99%

Nonlinear derating of high-intensity focused ultrasound beams using Gaussian modal sums

Dibaji

Banerjee

Soneson

et al. 2013

The Journal of the Acoustical Society of America

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A method is introduced for using measurements made in water of the nonlinear acoustic pressure field produced by a high-intensity focused ultrasound transducer to compute the acoustic pressure and temperature rise in a tissue medium. The acoustic pressure harmonics generated by nonlinear propagation are represented as a sum of modes having a Gaussian functional dependence in the radial direction. While the method is derived in the context of Gaussian beams, final results are applicable to general transducer profiles. The focal acoustic pressure is obtained by solving an evolution equation in the axial variable. The nonlinear term in the evolution equation for tissue is modeled using modal amplitudes measured in water and suitably reduced using a combination of "source derating" (experiments in water performed at a lower source acoustic pressure than in tissue) and "endpoint derating" (amplitudes reduced at the target location). Numerical experiments showed that, with proper combinations of source derating and endpoint derating, direct simulations of acoustic pressure and temperature in tissue could be reproduced by derating within 5% error. Advantages of the derating approach presented include applicability over a wide range of gains, ease of computation (a single numerical quadrature is required), and readily obtained temperature estimates from the water measurements.

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Section: A Computational Designmentioning

confidence: 99%

Nonlinear derating of high-intensity focused ultrasound beams using Gaussian modal sums

Dibaji

Banerjee

Soneson

et al. 2013

The Journal of the Acoustical Society of America

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“…A HIFU-Simulator [19] was customized to the HMI configuration. This module consisted of 1) a KhokhlovZabolotskaya-Kuznetsov (KZK) [20] based nonlinear acoustic module for simulation of the pressure and intensity field, and 2) a conventional BHT-based thermal module for simulation of the temperature change and lesion map surrounding the focal region.…”

Section: A Ultrasoundmentioning

confidence: 99%

A comprehensive framework for Harmonic Motion Imaging for Focused Ultrasound (HMIFU) with ex vivo validation

Hou

Luo

Maruet

et al. 2011

2011 IEEE International Ultrasonics Symposium

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Harmonic Motion Imaging for Focused Ultrasound (HMIFU) is a novel high-intensity focused ultrasound (HIFU) therapy monitoring method with feasibilities demonstrated in vitro, ex vivo and in vivo. Its principle is based on Amplitudemodulated (AM) -Harmonic Motion Imaging (HMI), an oscillatory radiation force used for imaging the tissue mechanical response during thermal ablation. In this study, a theoretical framework of HMIFU is presented, comprising a customized nonlinear wave propagation model, a finite-element (FE) analysis module, and an image-formation model. The objective of this study is to develop such a framework in order to 1) assess the fundamental performance of HMIFU in detecting HIFU lesions based on the change in tissue apparent elasticity, i.e., the increasing Young's modulus, and the HIFU lesion size with respect to the HIFU exposure time and 2) validate the simulation findings ex vivo. The same HMI and HMIFU parameters as in the experimental studies were used, i.e., 4.5-MHz HIFU frequency and 25 Hz AM frequency. For a lesion-to-background Young's modulus ratio of 3, 6, and 9, the estimated HMI displacement ratios were equal to 1.65, 3.19, 4.59, respectively. In experiments, the HMI displacement followed a similar increasing trend of 1.19, 1.28, 1.78 at 10-s, 20-s, and 30-s HIFU exposure, respectively. In addition, moderate agreement in lesion size growth was also found in both simulations (16.2, 73.1 and 334.7 mm 2 ) and experiments (26.2, 94.2 and 206.2 mm 2 ). Therefore, the feasibility of HMIFU for HIFU lesion detection based on the underlying tissue elasticity changes was verified through the developed theoretical framework, i.e., validation of the fundamental performance of the HMIFU system for lesion detection, localization and quantification, was demonstrated both theoretically and ex vivo.

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“…In order to ensure safety and efficacy of HIFU devices, preclinical evaluations of the thermal and acoustic field generated by the HIFU transducers are necessary. Preclinical testing of HIFU systems has been performed using computational modeling [3][4][5][6][7], ex-vivo [8][9][10][11] or in-vivo [12][13][14][15] animal tissues, and tissue phantoms [16][17][18][19]. The advantage of using phantoms with tissue mimicking material (TMM) is that such test sections can be reused repeatedly without affecting acoustical and thermal properties, which can be made similar to that of human tissue [20].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Heat Transfer and Thermal Dose Using Magnetic Nanoparticles During HIFU Thermal Ablation—An In-Vitro Study

Dibaji

Al-Rjoub

Myers

et al. 2013

Journal of Nanotechnology in Engineering and Medicine

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Avoiding collateral damage to healthy tissues during the high intensity focused ultrasound (HIFU) ablation of malignant tumors is one of the major challenges for effective thermal therapy. Such collateral damage can originate out of the need for using higher acoustic powers to treat deep seated or highly vascularized tumors. The objective of this study is to assess the utility of using magnetic nanoparticles (mNPs) during HIFU procedures to locally enhance heating at low powers, thereby reducing the likelihood of collateral thermal damage and undesired destruction due to cavitation. Tissue phantoms with 0% (control), 1% and 3% mNPs concentrations by volume were fabricated. Each tissue phantom was embedded with four thermocouples (TCs) and sonicated using transducer acoustic powers of 5.15 W, 9.17 W, and 14.26 W. The temperature profiles during the heating and cooling periods were recorded for each embedded TC. The measured transient temperature profiles were used for thermal-dose calculations. The increase in the concentration of mNPs in the tissue phantoms, from 0% to 3%, resulted in the rise in the peak temperatures for all the TCs for each acoustic power. The thermal dose also increased with the rise in the concentration of mNPs in the tissue phantoms. For the highest applied acoustic power (14.26 W), the peak temperature at TC 1 (T1) in tissue phantoms with 1% and 3% mNPs concentrations increased (with respect to tissue phantom with 0% (control) mNPs concentration) by 1.59Â and 2.09Â, respectively. For an acoustic power of 14.26 W, the time required to achieve cellular necrosis as defined by a 240 equivalent min thermal dose was approximately 75 s in the absence of mNPs, 14 s for the 1% concentration, and 8 s for the 3% concentration. Magnetic nanoparticles have the potential to significantly reduce the time for HIFU thermal-ablation procedures. They can also decrease the likelihood of collateral damage by the propagating beam in HIFU procedures by reducing the intensity required to achieve cellular necrosis.

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A User-Friendly Software Package for HIFU Simulation

Cited by 96 publications

References 5 publications

Nonlinear derating of high-intensity focused ultrasound beams using Gaussian modal sums

Nonlinear derating of high-intensity focused ultrasound beams using Gaussian modal sums

A comprehensive framework for Harmonic Motion Imaging for Focused Ultrasound (HMIFU) with ex vivo validation

Enhanced Heat Transfer and Thermal Dose Using Magnetic Nanoparticles During HIFU Thermal Ablation—An In-Vitro Study

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