A vaccine and diagnostic target for Clostridium bolteae, an autism-associated bacterium

Pequegnat, Brittany; Sagermann, Martin; Valliani, Moez; Toh, Michael; Chow, H. S.; Allen‐Vercoe, Emma; Monteiro, Mário A.

doi:10.1016/j.vaccine.2013.04.018

Cited by 59 publications

(79 citation statements)

References 30 publications

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“…Several species of microbiota have been postulated to be associated with ASD. In particular, the presence of Micobacterium paratuberclosis may evoke antibodies that interact with the myelin basic protein in the CNS (Dow, 2011), while Clostridium bolteae and Sutterella species have been proposed to elicit antibody production that aggravates gastrointestinal co-morbidities (Pequegnat et al, 2013;Williams, Hornig, Parekh, & Lipkin, 2012). Re-establishing microbial balance through Fecal Microbiota Transplant (FMT) has been shown to alleviate gastrointestinal and core autistic symptoms (Kang et al, 2017;Moon et al, 2015;Palm et al, 2014).…”

Section: Microbiota and Antibodiesmentioning

confidence: 99%

A systematic review of gut‐immune‐brain mechanisms in Autism Spectrum Disorder

Azhari

Azizan

Esposito

2018

Developmental Psychobiology

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Despite decades of research, the etiological origins of Autism Spectrum Disorder (ASD) remain elusive. Recently, the mechanisms of ASD have encompassed emerging theories involving the gastrointestinal, immune, and nervous systems. While each of these perspectives presents its own set of supporting evidence, the field requires an integration of these modular concepts and an overarching view of how these subsystems intersect. In this systematic review, we have synthesized relevant evidences from the existing literature, evaluating them in an interdependent manner and in doing so, outlining their possible connections. Specifically, we first discussed gastrointestinal and immuno‐inflammation pathways in‐depth, exploring the relationships between microbial composition, bacterial metabolites, gut mucosa, and immune system constituents. Accounting for temporal differences in the mechanisms involved in neurodevelopment, prenatal and postnatal phases were further elucidated, where the former focused on maternal immune activation (MIA) and fetal development, while the latter addressed the role of immune dysregulation in contributing to atypical neurodevelopment. As autism remains, foremost, a neurodevelopmental disorder, this review presents an integration of disparate modules into a “Gut‐Immune‐Brain” paradigm. Existing gaps in the literature have been highlighted, and possible avenues for future research with an integrated physiological perspective underlying ASD have also been suggested.

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Section: Microbiota and Antibodiesmentioning

confidence: 99%

A systematic review of gut‐immune‐brain mechanisms in Autism Spectrum Disorder

Azhari

Azizan

Esposito

2018

Developmental Psychobiology

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“…Excluding the phylotypes mentioned above, Enterorhabduscaecimuris has been isolated from mice with spontaneous colitis [19]. Clostridium bolteae has been shown to be overabundant in the intestinal tract of autistic children suffering from gastric intestinal ailments [20]. They probably associate with the disease.…”

Section: Resultsmentioning

confidence: 99%

“…As mentioned above, overabundance of this bacterium is found in the intestinal tract of autistic children suffering from gastric intestinal ailments [20]. …”

Section: Resultsmentioning

confidence: 99%

Alteration of Intestinal Microbiota in Mice Orally Administered with Salmon Cartilage Proteoglycan, a Prophylactic Agent

2013

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Proteoglycan (PG) extracted from salmon nasal cartilage has potential to be a prophylactic agent. Daily oral administration of the PG attenuates systemic inflammatory response in the experimental mouse models. In this study, we applied the culture-independent approach to investigate an alteration of intestinal microbiota composition in PG-administered mice. The results indicated that the population level of bacilli increased in the small and large intestine upon PG administration. On the other hand, the population level of clostridia decreased in the large intestine. The proportion of bacteria that are able to ferment saccharides and produce short-chain fatty acids increased in the small intestine and decreased in the large intestine. Importantly, population level of probiotic lactobacilli and bacteria exhibiting the immunomodulatory effect increased in the PG-administered mice. In addition, several disease-associated bacteria decreased upon PG administration. These results provided an understanding of the specific role of PG involved in host immune modulation and supported our hypothesis that daily oral administration of PG improves the overall balance in composition of the intestinal microbial community.

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“…В ýтой связи достаточно актуально повышение со-держания Clostridium bolteae в микробиоте ки-шечника при болезни Паркинсона, поскольку для данных бактерий показана ассоциация с аутиз-мом [32]. Кроме того, в микробиоте кишечника пациентов с болезнью Паркинсона отмечается повышение представленности бактерий, способ-ных оказывать влияние на работу нейронов.…”

Section: оригинальные статьиunclassified