A valid option for asthma control: Clinical evidence on efficacy and safety of fluticasone propionate/formoterol combination in a single inhaler

Latorre, Manuela; Paggiaro, Pier Luigi; Canonica, Giorgio Walter; Foschino, Maria Pia; Papi, A

doi:10.1016/j.pupt.2015.08.004

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Fluticasone propionate is a corticosteroid that is extensively used in the treatment of asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis, and nasal polyps. [26][27][28][29] The objective of the present study was to determine the time point(s) at which the maximum concentration of fluticasone propionate (Cmax) occurs in synovial fluid and plasma in Beagle dog knees after an IA with EP-104IAR.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetic Profile of Intra-articular Fluticasone Propionate Microparticles in Beagle Dog Knees

et al. 2017

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Objective The objective of this pilot study was to determine time point(s) at which maximum concentration of fluticasone propionate (Cmax) occurs in synovial fluid and plasma in Beagle dog knees after intra-articular injection of EP-104IAR. Design EP-104IAR is composed of fluticasone propionate drug crystals coated with heat-treated polyvinyl alcohol (PVA) to result in extended release properties. Thirty-two Beagle dogs had an injection of EP-104IAR into the knee joint at 2 different dose levels (0.6 mg and 12 mg). Outcome measures included plasma, synovial fluid, and articular cartilage fluticasone propionate concentrations as well as histological analysis of cartilage and synovium at a variety of time points up to 58 days postdosing. Results Intra-articular administration of 0.6 and 12 mg EP-104IAR was well tolerated. Early minor abnormalities found on microscopy resolved by the end of the study. There were no quantifiable concentrations of fluticasone propionate in plasma of animals administered 0.6 mg at any of the sampling time points. Highest concentrations in plasma following 12 mg administration occurred 1 day postdose and declined with a half-life of approximately 45 days. Highest concentrations of fluticasone propionate in synovial fluid and cartilage generally occurred 5 days postdose in both dose groups and declined with a half-life of approximately 11 to 14 days. Conclusions EP-104IAR is capable of providing a safe and prolonged local exposure to a corticosteroid in the synovial joint while minimizing systemic exposure, with peak exposures occurring within a matter of days after dosing before declining in all tissues in a predictable manner.

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Section: Introductionmentioning

confidence: 99%

“…Fluticasone propionate is a corticosteroid that is extensively used in the treatment of asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis, and nasal polyps. 26-29…”

Section: Introductionmentioning

confidence: 99%