A validated UPLC method for the determination of process-related impurities in Azathioprine bulk drug

Davadra, Prakash M.; Mepal, Vivek V.; Jain, Mukul; Joshi, Chhelshanker G.; Bapodra, Atul H.

doi:10.1039/c0ay00406e

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Starting materials, intermediates, precursors, etc., are the most common impurities found in every API unless proper care is taken in every step involved throughout the multi-step synthesis. Sometimes, impurities of intermediates and precursors generate structurally related by-products during synthesis [56].…”

Section: Detection Of Impuritiesmentioning

confidence: 99%

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Principles and Applications of Ultra-High-Performance Liquid Chromatography

Ahmed¹,

Eticha²,

Hymete³

et al. 2023

High Performance Liquid Chromatography - Recent Advances and Applications

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The science of separation had advanced significantly with the development of ultra-high-performance liquid chromatography (UHPLC), a brand-new type of liquid chromatography. The need for the evolution of HPLC into UHPLC has been driven by the continuously evolving of packing material modifications that affect the separation of mixtures. The separation process of analytes is completed in a substantially decreased amount of time due to the lower particle sizes, which increases surface area of interaction allowing reduction of column length to one-third; thus, shorter columns are employed in UHPLC, which consequently causes the flow rate to be three times higher and subsequently reducing analysis time. Although UHPLC shares the same fundamental idea and instrument layout as HPLC, it differs from HPLC in that it produces narrow peaks and has high spectral quality, allowing for simple compound identification in a variety of analytical applications such as impurity profiling, product formulation, and improved analytical technique and method development. However, high back pressure in UHPLC might lead to decreased column life, and the instrument’s higher price compared to HPLC are the disadvantages.

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Section: Detection Of Impuritiesmentioning

confidence: 99%

“…validated. The validation results also indicated positive data for each of the examined parameters [56][57][58][59][60][61][62][63].…”

Section: Detection Of Impuritiesmentioning

confidence: 99%

Principles and Applications of Ultra-High-Performance Liquid Chromatography

Ahmed¹,

Eticha²,

Hymete³

et al. 2023

High Performance Liquid Chromatography - Recent Advances and Applications

View full text Add to dashboard Cite

show abstract

“…Purine analogues are less hydrophilic than pyrimidine analogues. Thus, RPLC was the main technique employed for the analysis of both the first [118][119][120][121][122][123][124][125] and second generation [126][127][128] purine analogues. It should be noted that several studies were based on the analysis of the products resulting from the …”

Section: Antimetabolitesmentioning

confidence: 99%

Antineoplastic drugs and their analysis: a state of the art review

Guichard

Guillarme

Bonnabry

et al. 2017

Analyst

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The number of patients suffering from cancer is constantly increasing and, consequently, the number of different chemotherapy treatments administered is increasing. Given the high reactivity and toxicity of antineoplastic drugs, analytical methods are required in all pharmaceutical fields, from drug development to their elimination in wastewater; including formulation quality control, environment and human exposure and therapeutic drug monitoring. The aim of this paper is to provide an overview of the analytical methods available for the determination of antineoplastic drugs in different matrices such as pharmaceutical formulations, biological and environmental samples. The applicability and performance of the reported methods will be critically discussed, with focus on the most commonly used antineoplastic drugs. Only conventional compounds and small molecules for targeted therapy will be considered in the present review.

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