A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis

Li, Xiaodong; Li, Zhigao; Song, Xian-Xu; Liu, Chunfu

doi:10.3109/00313025.2010.522175

Cited by 93 publications

(89 citation statements)

References 29 publications

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“…Previous studies indicated that miR-196a2C>T polymorphisms have been widely investigated in various cancers, such as non-small cell lung cancer, breast cancer, pancreatic cancer and esophageal cancer as well as gastric cancer (Zhan et al, 2012;Linhares et al, 2012;Pavlakis et al, 2013;Wei et al, 2013;Yuan et al, 2013). Three studies reported that miR-196a2C>T polymorphism are associated with development of HCC (Li et al, 2010;Qi et al, 2010). A study conducted in Chinese HBV-related HCC patients demonstrated that the risk of HCC was significantly higher with miR-196a2 CT genotype or T allele compared with those with the CC genotype (Qi et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Another study with 310 HCC patients and 222 controls indicated that miR-196a2 CC genotype was associated with significantly increased mature miR-196a expression, and miR-196a2 polymorphism may contribute to cirrhosis-related HCC susceptibility in Chinese patients through influencing mature miR-196a expression (Li et al, 2010). Our study reported that miR-196a2 CC genotype and C allele significantly increased the risk of HCC when compared with CC genotype, which was in line with previous studies (Li et al, 2010;Qi et al, 2010). However, the results are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

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Associations Between Three Common MicroRNA Polymorphisms and Hepatocellular Carcinoma Risk in Chinese

Hao

Wang²,

Zhao³

2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Associations Between Three Common MicroRNA Polymorphisms and Hepatocellular Carcinoma Risk in Chinese

Hao

Wang²,

Zhao³

2013

Asian Pacific Journal of Cancer Prevention

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“…Hoffman et al (2009) found that miR-196a2 rs11614913 not only influences the mature miR196a levels, but also has a phenotypic effect on target gene expression, as a total of 684 transcripts were altered expression following introduction of pre-miR-196a-C, and fewer than half of that number were significantly altered after introduction of pre-miR-196a-T (Wang et al, 2012). Numerous studies have shown that individuals carrying the CC genotype show a significantly increased risk of breast cancer, lung cancer, gastric cancer, colorectal cancer, and hepatocellular carcinoma compared to those with the TT or TT+TC genotypes (Li et al, 2010;Lee et al, 2014). …”

Section: Discussionmentioning

confidence: 99%

Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population

Qi¹,

Wang²,

Zhou³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide polymorphisms (mir-499 rs3746444 A>G; miR-27a rs895819 A>G; miR-196a2 rs11614913 T>C; miR-146a rs2910164 G/C) were detected using Taqman assays. Mature miRNA expression, allele distribution, and the association with clinical features were further analyzed. Our results showed that the miR146a rs2910164 G/C polymorphism was associated with an elevated risk of breast cancer (odds ratio = 1.85, 95% confidence interval = 1.03-3.32; P < 0.05). Compared with the ancestral T allele in miR-196a2 rs11614913, the variant C allele was consistently associated with an increased risk of breast cancer (odds ratio = 2.20, 95% confidence interval = 1.19-4.09, P < 0.01) and clinical pathological type (P < 0.01). miR-27a rs895819 A>G and miR-499 rs3746444 A>G were not associated with breast cancer risk. Analysis of mature miRNA expression confirmed that the variant C allele in miR146a rs2910164 and miR-196a2 rs11614913 dramatically inhibited production of their mature products. Our results suggested that miR-146a rs2910164 G>C and miR-196a2 rs11614913 T>C may be biomarkers for predicting breast cancer risk in the Chinese population.

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“…The TC/CC genotypes in rs4938723 in the promoter region of pri-miR-34b/c were investigated and shown to be associated with significantly increased susceptibility and risks in HCC compared with the wild-type TT patients [34]. However, the patients with CT and CC genotypes of the rs11614913 SNP in mature miR-196a2 might have altered susceptibility and progression of HCC and also have a higher risk of developing HCC [35]. Similarly, a study detected that the rs999885 AG/GG genotypes located in the miR106b-25 cluster sequence were apparently associated with an increased HCC risk compared with that in the AA genotype carriers [36].…”

Section: Mirna and Genetic Predisposition For Hccmentioning

confidence: 99%

miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

Chu

Duan

et al. 2014

Cell Communication and Signaling

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The pathogenesis of hepatocellular carcinoma (HCC) is not fully understood, which has affected the early diagnosis and treatment of HCC and the survival time of patients. MicroRNAs (miRNAs) are a class of evolutionarily conserved small, non-coding RNAs, which regulate the expression of various genes post-transcriptionally. Emerging evidence indicates that the key enzymes involved in the miRNA biosynthesis pathway and some tumor-specific miRNAs are widely deregulated or upregulated in HCC and closely associated with the occurrence and development of various cancers, including HCC. Early studies have shown that miRNAs have critical roles in HCC progression by targeting many critical protein-coding genes, thereby contributing to the promotion of cell proliferation; the avoidance of apoptosis, inducing via angiogenesis; and the activation of invasion and metastasis pathways. Experimental data indicate that discovery of increasing numbers of aberrantly expressed miRNAs has opened up a new field for investigating the molecular mechanism of HCC progression. In this review, we describe the current knowledge about the roles and validated targets of miRNAs in the above pathways that are known to be hallmarks of HCC, and we also describe the influence of genetic variations in miRNA biosynthesis and genes.

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A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis

Cited by 93 publications

References 29 publications

Associations Between Three Common MicroRNA Polymorphisms and Hepatocellular Carcinoma Risk in Chinese

Associations Between Three Common MicroRNA Polymorphisms and Hepatocellular Carcinoma Risk in Chinese

Associations of miRNA polymorphisms and expression levels with breast cancer risk in the Chinese population

miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

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