miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

Chu, Rui; Mo, Guangquan; Duan, Zhijun; Huang, Mei; Chang, Jiuyang; Li, Xiaodong; Liu, Pixu

doi:10.1186/preaccept-5069088841256961

Cited by 17 publications

(20 citation statements)

References 65 publications

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“…HCC carcinogenesis is a multistep process through accumulation of genetic and epigenetic alterations. Although the risk factors for HCC are well characterized, the molecular pathogenesis is not well understood 4 5 . Thus, the identification of new possible targets for preventing the initiation and progression of HCC is imperative and must be improved.…”

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confidence: 99%

MiR-148b suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting WNT1/β-catenin pathway

Zhang

Shi

Hong

et al. 2015

Sci Rep

106

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Accumulating evidences indicate that microRNAs play a vital role in regulating tumor progression. However, the roles of miR-148b in hepatocellular carcinoma (HCC) are still largely unknown. In this study, our data showed that miR-148b was significantly downregulated in 40 pairs of human HCC tissues. Further, the deregulated miR-148b was significantly correlated with larger tumor size, more tumor number, metastasis and worse prognosis in HCC. Overexpression of miR-148b inhibited HCC HepG2 cells proliferation and tumorigenicity. Further, miR-148b induced cells apoptosis by activating caspase- 3 and caspase-9, and induced S phase arrest by regulating cyclinD1 and p21, and also inhibited cell invasion. Data from the dual-luciferase reporter gene assay showed that WNT1 was a direct target of miR-148b, and overexpressed WNT1 inversely correlated with miR-148b levels in HCC tissues. Silencing of WNT1 inhibited the growth of HCC cells, and also induced cells apoptosis and inhibited invasion, which is consistent with the effects of miR-148b overexpression. MiR-148b downregulated expression of WNT1, β-catenin and C-myc, while upregulated E-cadherin expression. We conclude that the frequently downregulated miR-148b can regulate WNT1/β-catenin signalling pathway and function as a tumor suppressor in HCC. These findings suggest that miR-148b may serve as a novel therapeutic target for HCC.

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mentioning

confidence: 99%

MiR-148b suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting WNT1/β-catenin pathway

Zhang

Shi

Hong

et al. 2015

Sci Rep

106

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“…Through imperfect pairing with target mRNAs of protein-coding genes, evidence that MiRNAs played an important role in various crucial biological processes has been showed by earlier researches [22,23]. Noncoding RNA includes highly plentiful and functionally important RNAs, such as MicroRNAs and long noncoding RNAs.…”

Section: Discussionmentioning

confidence: 99%

Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

Liu

Wang

et al. 2020

Preprint

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Background It has been proved that a significant proportion of prostate cancer diagnoses may be associated with a strong hereditary component. Micro-RNAs and Long Non-coding RNAs are a group of a noncoding small molecule, which play critical roles in signalling pathways, metabolism, apoptosis and cancer development. Exercising a meta-analysis to examine the relationship between rs3746444, rs3787016 and prostate cancer (PCa) risk was the main objective of our study. Results 10 case-control studies were included, while 6 on rs3787016 and 4 on rs3746444. On the whole, the genotypes carrying the T allele, in which were verified an increased risk between rs3787016 and PCa risk.( T vs C: odds ratio(OR) = 1.802, 95% CI 1.015–3.198, P value of heterogeneity(PH) = 0.00%; CT vs CC: OR = 1.179,95% CI 1.091–1.275, PH = 0.41; TT vs CC: .OR = 1.418, 95% CI 1.229–1.636, PH= 0.961; TT + CT vs CC: OR = 1.216, 95% CI 1.129–1.310, PH= 0.408; TT vs CT + CC: OR = 1.328, 95%CI 1.159–1.521, PH = 0.987). A vital relevance was performed by this meta-analysis in three models between rs3746444 and PCa risk, in which a tendency of increased PCa risk could be found (C vs T: OR = 1.197, 95% CI 1.035–1.384, PH= 0.837; CC vs TT: OR = 1. 137, 95% CI 0.813–1.590, PH = 0.392; CC + CT vs TT: OR = 1.426, 95% CI 1.166–1.743, PH= 0.406.). Conclusion Our findings proposed that rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E polymorphisms increased the risk of developing PCa. Further functional studies are warranted to reveal the role of the polymorphism in carcinogenesis.

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“…Deregulated expression of miRNA could contribute to the pathogenesis of HCC through the downregulation of miRNAs that modulate oncogenes, or the upregulation of miRNA that can target tumor suppressor genes. 16,17 Among the most prominent deregulated miRNAs in HCC are miR-221, miR-21, and miR-18 that are upregulated in HCC and miR-122a, miR-199a, and miR-200 that are downregulated in HCC. ►Table 1 summarizes selected differentially expressed miRNAs, their target genes, and potential involvement in HCC or other cancers.…”

Section: Micrornas In Hepatocellular Carcinomamentioning

confidence: 99%

Noncoding RNA as Therapeutic Targets for Hepatocellular Carcinoma

George

Patel

2015

Semin Liver Dis

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Recent studies have suggested that non-coding RNAs (ncRNAs) contribute to the pathogenesis and progression of hepatocellular carcinoma (HCC). These RNA genes may be involved in various pathobiological processes such as cell proliferation, apoptosis, angiogenesis, invasion, and metastasis. Aberrant expression of ncRNA resulting from deregulated epigenetic, transcriptional or post-transcriptional activity has been described in several studies. ncRNAs comprise of a highly diverse group of transcripts that include microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as well as several other types of RNA genes. Understanding the molecular mechanisms by which ncRNA contribute to hepatocarcinogenesis may enable the design of ncRNA based therapeutics for HCC. This review provides a perspective on therapeutic applications based on the emerging evidence of a contributory role of miRNAs and lncRNAs to the pathogenesis and progression of HCC. In addition, ncRNA that are deregulated in expression in HCC may have utility as potential prognostic or diagnostic markers.

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miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression

Cited by 17 publications

References 65 publications

MiR-148b suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting WNT1/β-catenin pathway

MiR-148b suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting WNT1/β-catenin pathway

Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

Noncoding RNA as Therapeutic Targets for Hepatocellular Carcinoma

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