A Variant of Wolf’s Isotopic Response - Overriding of Two Blistering Diseases

Abstract

ABSTRACT:The term Wolfs isotopic response refers to the occurrence of an unrelated dermatologic disease over the site of an already healed skin disease. The primary disease is usually a healed Herpes zoster scar and the second dermatoses are frequently granulomatous or lichenoid reactions. We report a variant of this phenomenon with co localization of active herpes zoster and Pemphigus vulgaris over the left upper limb as evidenced by the presence of both giant epithelial cells and positive direct immuno fluorescence for pemphigus. To the best of our knowledge such an association has not been reported earlier.