A Vasoactive Intestinal Peptide Binding Component in Hen Granulosa Cells

Kawashima, Mitsuo; Takahashi, Tetsuya; Yasuoka, Tadashi; Kamiyoshi, Michiharu; Tanaka, Katuhide

doi:10.3181/00379727-209-43912

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…The presence of neuropeptide receptors in the gonads: GnRH-R in mammals (Jones et al, 1980; Whitelaw et al, 1995; Schirman-Hildesheim et al, 2005)and fish, (von Schalburg et al, 1999; Bogerd et al, 2002); galanin receptor in mammals (Romanelli et al, 1998); vasoactive intestinal peptide receptor (VIP-R) in birds and mammals (Johnson and Tilly, 1988; Kawashima, 1995; El-Gehani et al, 1998; Bajo et al, 2000; Vaccari et al, 2006); NPY-R in mammals (Kopp et al, 1997); CRF-R in mammals (Heinrich et al, 1998; Waser et al, 2006), urocortin receptor in mammals (Florio et al, 2004) and kisspeptin receptor (GPR54) in mammals (Shahed and Young, 2009), supports this function. See Table 1 for further clarification.…”

Section: Introductionmentioning

confidence: 99%

Neuropeptides in the gonads: from evolution to pharmacology

McGuire

Bentley

2010

Front. Pharmacol.

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Vertebrate gonads are the sites of synthesis and binding of many peptides that were initially classified as neuropeptides. These gonadal neuropeptide systems are neither well understood in isolation, nor in their interactions with other neuropeptide systems. Further, our knowledge of the control of these gonadal neuropeptides by peripheral hormones that bind to the gonads, and which themselves are under regulation by true neuropeptide systems from the hypothalamus, is relatively meager. This review discusses the existence of a variety of neuropeptides and their receptors which have been discovered in vertebrate gonads, and the possible way in which such systems could have evolved. We then focus on two key neuropeptides for regulation of the hypothalamo-pituitary-gonadal axis: gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibitory hormone (GnIH). Comparative studies have provided us with a degree of understanding as to how a gonadal GnRH system might have evolved, and they have been responsible for the discovery of GnIH and its gonadal counterpart. We attempt to highlight what is known about these two key gonadal neuropeptides, how their actions differ from their hypothalamic counterparts, and how we might learn from comparative studies of them and other gonadal neuropeptides in terms of pharmacology, reproductive physiology and evolutionary biology.

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Section: Introductionmentioning

confidence: 99%

Neuropeptides in the gonads: from evolution to pharmacology

McGuire

Bentley

2010

Front. Pharmacol.

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“…In the literature only scarce papers dealing with the VIP/PACAP receptors can be found. In the human ovary the VIP binding and VPAC1 expression (with immunoblot) were shown (Bajo et al 2000) as well as the binding of VIP by the hen granulosa cells (Kawashima et al 1995). It is known that in the ovary VIP stimulates the synthesis of cAMP, estradiol and progesterone (Davoren and Hsueh 1985).…”

Section: Discussionmentioning

confidence: 99%

Expression of VPAC1 receptor at the level of mRNA and protein in the porcine female reproductive system

Bukowski¹,

Wąsowicz²

2015

Polish Journal of Veterinary Sciences

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The presence and distribution of vasoactive intestinal polypeptide (VIP) receptor VPAC1 was studied in the ovary, oviduct and uterus (uterine horn and cervix) of the domestic pig using methods of molecular biology (RT-PCR and immunoblot) and immunohistochemistry.The expression of VPAC1 receptor at mRNA level was confirmed with RT-PCR in all the studied parts of the porcine female reproductive system by the presence of 525 bp PCR product and at the level of proteins by the detection of 46 kDa protein band in immunoblot. Immunohistochemical stainings revealed the cellular distribution of VPAC1 receptor protein. In the ovary it was present in the wall of arterial blood vessels, as well as in the ovarian follicles of different stages. In the tubular organs the VPAC1 receptor immunohistochemical stainings were observed in the wall of the arterial blood vessels, in the muscular membrane, as well as in the mucosal epithelium.The study confirmed the presence of VPAC1 receptor in the tissues of the porcine female reproductive tract what clearly shows the possibility of influence of VIP on the porcine ovary, oviduct and uterus.

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“…It has been suggested that a single VIP receptor is expressed and functions in nonmammalian species [31]. In birds, VIP receptors are present on the surface membranes of the anterior pituitary [32][33][34], the hypothalamus [35], the small intestine, and the granulosa cells [36]. VIP stimulation increases levels of intracellular cAMP in chicken pituitary cells [37] and in the hypothalamus [38].…”

Section: Introductionmentioning

confidence: 99%

Expression of Vasoactive Intestinal Peptide Receptor Messenger RNA in the Hypothalamus and Pituitary Throughout the Turkey Reproductive Cycle1

Chaiseha

Youngren

Halawani

2004

Biology of Reproduction

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Vasoactive intestinal peptide (VIP) has been implicated in the regulation of avian reproductive activity and appears to act at the level of the hypothalamus and pituitary. This in situ hybridization histochemistry study describes the distribution of VIP receptor mRNA expression in the hypothalamus and the pituitary of reproductively active (laying) and quiescent (nonphotostimulated, incubating, and photorefractory) female turkeys and characterizes the differences observed in VIP receptor gene expression. VIP receptor mRNA, while expressed throughout the hypothalamus, was specifically expressed in areas known to contain GnRH-I neurons in the chicken, i.e., the lateral septum, medial preoptic area, anterior hypothalamus, and paraventricular nucleus. Significant differences in VIP receptor mRNA expression between different reproductive states was observed only within the infundibular nuclear complex. VIP receptor mRNA was markedly less in nonphotostimulated and photorefractory hens as compared with laying and incubating hens. The most dense VIP receptor mRNA was found in the anterior pituitary, where it was 2.4- and 3.0-fold greater in laying and incubating hens, respectively, as compared with that in nonphotostimulated ones. Hens that stopped incubating and became photorefractory displayed pituitary VIP receptor mRNA levels similar to those of nonphotostimulated birds. The changes in pituitary VIP receptor mRNA expression were positively correlated with known changes in pituitary prolactin (PRL) mRNA expression and PRL content and release. These findings indicate that the variations in PRL secretion observed across the turkey reproductive cycle are, in part, regulated by changes in VIP receptors at the pituitary level.

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A Vasoactive Intestinal Peptide Binding Component in Hen Granulosa Cells

Cited by 7 publications

References 23 publications

Neuropeptides in the gonads: from evolution to pharmacology

Neuropeptides in the gonads: from evolution to pharmacology

Expression of VPAC1 receptor at the level of mRNA and protein in the porcine female reproductive system

Expression of Vasoactive Intestinal Peptide Receptor Messenger RNA in the Hypothalamus and Pituitary Throughout the Turkey Reproductive Cycle1

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