A Ventrolateral Medulla-Midline Thalamic Circuit for Hypoglycemic Feeding

Beas, B. Sofia; Gu, Xinglong; Leng, Yan; Koita, Omar; Rodriguez-Gonzalez, Shakira; Kindel, Morgan; Matikainen‐Ankney, Bridget A.; Larsen, Rylan S.; Kravitz, Alexxai V.; Hoon, Mrinalini; Penzo, Mario

doi:10.1016/j.biopsych.2021.02.046

Cited by 10 publications

(24 citation statements)

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“…Although we cannot rule out yet whether and how the adaptive activation of PVT-neurons following TH deletion may be responsible for the direct activation of LH and DMH regions, it is interesting to note that PVT excitatory (glutamate) neurons also project to the hypothalamus 29,76 , therefore potentially modulating feeding and energy homeostasis. Indeed, while the existence of a hypothalamus→PVT→accumbal circuit seems critical for behavioral adaptations 7,26,29,77-80 , our results combined to previous and recent literature 8,16,17,76,81 also suggest a hindbrain→PVT→hypothalamus path that may regulate homeostatic functions requiring the integration of exteroceptive and interoceptive signals.…”

Section: Discussionsupporting

confidence: 72%

“…This plethora of PVT-related brain functions highly relies on different afferent projections which, by carrying distinct neurochemical information, synergistically scale the activity of PVT-neurons and their downstream connected regions. Among the different afferents, the PVT also harbors a dense plexus of catecholaminergic (CA) fibers mainly arising from the hindbrain (Schroeter et al, 2000;Beas et al, 2018;Sofia Beas et al, 2020;Wang et al, 2021b) and only few scattered CA fibers from the hypothalamus (Li et al, 2014). In addition, recent reports have indicated that brain CA (norepinephrine, NE, and/or dopamine, DA), by modulating different homeostatic functions (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Hindbrain catecholaminergic inputs to the paraventricular thalamus scale feeding and metabolic efficiency in stress-related contexts

Dumont

Castel

et al. 2022

Preprint

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Aim: The regulation of food intake and energy balance relies on the integration of exteroceptive and interoceptive signals monitoring nutritional, metabolic and emotional states. This study aims at unraveling the role of catecholaminergic (CA) inputs to the paraventricular thalamus (PVT) in scaling feeding and metabolic efficiency. Methods: To tackle this question, a region-specific retrograde disruption of PVT CA inputs was performed. Behavioral tests and in vivo calorimetric technologies were mobilized to study the adaptive strategies underlying feeding, metabolic efficiency and nutrient partitioning. Moreover, immunofluorescence investigations were conducted to identify the sources of TH-neurons projecting to the PVT and to reveal the molecular pattern of neuronal activation (cFos) in the PVT as well as in homeostasis-related regions of the hypothalamus. Results: First, we show that PVT CA inputs mainly arise from the hindbrain, notably the locus coeruleus (LC) and the nucleus tractus solitarius (NTS). Second, we reveal that PVT CA inputs contribute to feeding strategies and metabolic efficiency in environmental, behavioral, physiological and metabolic stress-like contexts. Third, we show that PVT CA inputs contribute in modulating the activity of PVT as well as lateral (LH) and dorsomedial (DMH) hypothalamic neurons. Conclusion: This study, by assessing the key role of PVT CA inputs in scaling homeostatic and allostatic regulations of feeding patterns, reveals the integrative and converging hindbrain→PVT paths that contribute to whole-body metabolic adaptations in stress-like contexts.

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Hindbrain catecholaminergic inputs to the paraventricular thalamus scale feeding and metabolic efficiency in stress-related contexts

Dumont

Castel

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…General arousal has also been conceptualized as a brain activation phenomena that invigorates behavior by enhancing the activity of the sensory and motor circuits (Pfaff et al 2008;Pfaff 2006) Hua et al 2018;Sofia Beas et al 2020;Leib et al 2017;Labouebe et al 2016;Zhu et al 2018;Meffre et al 2019). The PVT also receives signals related to predator odor via the ventromedial nucleus of the hypothalamus to suppress food reward seeking (Engelke et al 2021).…”

Section: Functional Considerationsmentioning

confidence: 99%

“…Brainstem catecholaminegic neurons regulate physiological and behavioral responses to homeostatic challenges via ramifying projections to many regions of the brain (Guyenet et al 2013;Card et al 2006;Rinaman 2011;Guyenet 2006;Dampney 1994;Aston-Jones and Cohen 2005). Recent papers have reported that catecholaminegic inputs to the PVT from the LC and VLM respectively modulates aversive stress and hypoglycemia-induced feeding responses (Beas et al 2018;Sofia Beas et al 2020).…”

Section: Introductionmentioning

confidence: 99%

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Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

Kirouac

2022

Preprint

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The paraventricular nucleus of the thalamus (PVT) projects to areas of the forebrain involved in behavior. Homeostatic challenges and salient cues activate the PVT and evidence shows that the PVT regulates appetitive and aversive responses. The brainstem is a source of afferents to the PVT and the present study was done to determine if the lateral parabrachial nucleus (LPB) is a relay for inputs to the PVT. Retrograde tracing experiments with cholera toxin B (CTB) demonstrate that the LPB contains more PVT projecting neurons than other regions of the brainstem including the catecholamine cell groups. The hypothesis that the LPB is a relay for brainstem signals to the PVT was assessed using an intersectional monosynaptic rabies tracing approach. Sources of inputs included the reticular formation, periaqueductal gray (PAG), nucleus cuneiformis, superior and inferior colliculi, and the LPB. Distinctive clusters of input cells to LPB-PVT projecting neurons were also found in the dorsolateral bed nucleus of the stria terminalis (BSTDL) and the lateral central nucleus of the amygdala (CeL). Anterograde viral tracing demonstrates that LPB-PVT neurons densely innervate all of the PVT in addition to providing collateral innervation to the preoptic area, lateral hypothalamus, zona incerta and PAG but not the BSTDL and CeL. The paper discusses the anatomical evidence that suggests that the PVT is part of a network of interconnected neurons involved in arousal, homeostasis, and the regulation of behavioral states with forebrain regions potentially providing descending modulation or gating of signals relayed from the LPB to the PVT.

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Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

Kirouac

2022

Brain Struct Funct

View full text Add to dashboard Cite

The paraventricular nucleus of the thalamus (PVT) projects to areas of the forebrain involved in regulating behavior. Homeostatic challenges and salient cues activate the PVT and evidence shows that the PVT regulates appetitive and aversive responses. The brainstem is a source of afferents to the PVT and the present study was done to determine if the lateral parabrachial nucleus (LPB) is a relay for inputs to the PVT. Retrograde tracing experiments with cholera toxin B (CTB) demonstrate that the LPB contains more PVT projecting neurons than other regions of the brainstem including the catecholamine cell groups. The hypothesis that the LPB is a relay for signals to the PVT was assessed using an intersectional monosynaptic rabies tracing approach. Sources of inputs to LPB included the reticular formation; periaqueductal gray (PAG); nucleus cuneiformis; and superior and inferior colliculi. Distinctive clusters of input cells to LPB-PVT projecting neurons were also found in the dorsolateral bed nucleus of the stria terminalis (BSTDL) and the lateral central nucleus of the amygdala (CeL). Anterograde viral tracing demonstrates that LPB-PVT neurons densely innervate all regions of the PVT in addition to providing collateral innervation to the preoptic area, lateral hypothalamus, zona incerta and PAG but not the BSTDL and CeL. The paper discusses the anatomical evidence that suggests that the PVT is part of a network of interconnected neurons involved in arousal, homeostasis, and the regulation of behavioral states with forebrain regions potentially providing descending modulation or gating of signals relayed from the LPB to the PVT.

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A Ventrolateral Medulla-Midline Thalamic Circuit for Hypoglycemic Feeding

Cited by 10 publications

References 0 publications

Hindbrain catecholaminergic inputs to the paraventricular thalamus scale feeding and metabolic efficiency in stress-related contexts

Hindbrain catecholaminergic inputs to the paraventricular thalamus scale feeding and metabolic efficiency in stress-related contexts

Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

Convergence of monosynaptic inputs from neurons in the brainstem and forebrain on parabrachial neurons that project to the paraventricular nucleus of the thalamus

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