A versatile 3D-printable hydrogel for antichondrosarcoma, antibacterial, and tissue repair

In situ formed scaffold with royal jelly-derived extracellular vesicles for wound healing

“…The washed cocoons (10 grams) were boiled in 0.02 M Na 2 CO 3 solution (400 mL) for 1 h, and then dialyzed against ddH 2 O with a dialysis bag with relative molecular weight of 3.5 kDa to remove Na 2 CO 3 , and finally sericin was obtained by freeze-drying. The method of using MA to modify sericin is consistent with previous reports 58 .…”

From materials to clinical use: advances in 3D-printed scaffolds for cartilage tissue engineering

“…ZIF-8 is a pH-responsive metal–organic framework (MOF) that has been frequently reported as a drug delivery vehicle. 163,165–167 SerMA solution loaded with nanoparticles can promote the repair of damaged cartilage tissue. The complex material design endows this hydrogel with the ability to promote tissue repair, spatiotemporally controlled release of drugs, antibacterial and anti-inflammatory properties, and photothermal killing ability of tumor cells, opening up new avenues for future scaffold functionalization research.…”

“…Facing a huge challenge of tissue reconstruction after chondrosarcoma surgery, Zhu et al developed a multifunctional hydrogel that can be directly written and printed with the assistance of photocrosslinking for this application scenario. 163 In their research, repair of defective tissue, tumor recurrence, and bacterial infection are three issues that may arise in this application scenario. To overcome these challenges, methacrylic anhydride-modified silk protein (SerMA) solution was prepared and mixed with proanthocyanidin-loaded zeolite imidazolate-skeleton 8(ZIF-8) nanoparticles modified by polydopamine (PDA) to obtain a PC@ZIF-8@PDA/SerMA hydrogel.…”

Recent progress of antibacterial hydrogel materials for biomedical applications

“…134 Moreover, antibacterial hydrogels are often used as carriers for the delivery of multiple drugs in cancer therapy, immunomodulation, cardiovascular generation, and heart repair. 135–137 With the progress of functional construction and performance regulation technology, antibacterial hydrogels have been applied in wound healing, 138 bone repair, 139 tissue adhesives, 140 antibacterial coating of medical devices, 141 photothermal antibacterial therapy, 142 sensing and human health monitoring, 143 cell encapsulation, 144 and others. Since the advantages of antibacterial hydrogels make it possible to apply them in all aspects of the medical field, the translational applications in this review are distinguished by their main functions (Table 2).…”