A versatile electrochemical sensing receptor based on a molecularly imprinted polymer

Udomsap, Dutduan; Branger, Catherine; Culioli, Gérald; Dollet, P.; Brisset, Hugues

doi:10.1039/c4cc02658f

Cited by 57 publications

(29 citation statements)

References 29 publications

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“…One example is the work developed by Udomsap et al [133] that reported a versatile electrochemical MIP-based sensor with the introduction of a redox probe (vinylferrocene) inside the binding cavities of a crosslinked MIP. The biomimetic sensor detected easily the analyte benzo[a]pyrene with LOD of 0.09 μmol/L [133]. …”

Section: Electrochemical Transductionmentioning

confidence: 99%

Imprinting Technology in Electrochemical Biomimetic Sensors

Frasco

Truta

Sales

et al. 2017

Sensors

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Biosensors are a promising tool offering the possibility of low cost and fast analytical screening in point-of-care diagnostics and for on-site detection in the field. Most biosensors in routine use ensure their selectivity/specificity by including natural receptors as biorecognition element. These materials are however too expensive and hard to obtain for every biochemical molecule of interest in environmental and clinical practice. Molecularly imprinted polymers have emerged through time as an alternative to natural antibodies in biosensors. In theory, these materials are stable and robust, presenting much higher capacity to resist to harsher conditions of pH, temperature, pressure or organic solvents. In addition, these synthetic materials are much cheaper than their natural counterparts while offering equivalent affinity and sensitivity in the molecular recognition of the target analyte. Imprinting technology and biosensors have met quite recently, relying mostly on electrochemical detection and enabling a direct reading of different analytes, while promoting significant advances in various fields of use. Thus, this review encompasses such developments and describes a general overview for building promising biomimetic materials as biorecognition elements in electrochemical sensors. It includes different molecular imprinting strategies such as the choice of polymer material, imprinting methodology and assembly on the transduction platform. Their interface with the most recent nanostructured supports acting as standard conductive materials within electrochemical biomimetic sensors is pointed out.

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Section: Electrochemical Transductionmentioning

confidence: 99%

Imprinting Technology in Electrochemical Biomimetic Sensors

Frasco

Truta

Sales

et al. 2017

Sensors

View full text Add to dashboard Cite

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“…Besides, using electroactive materials as signal probes is another good method. Brisset et al 521 introduced a redox tracer vinylferrocene (VFc) as an electrochemical sensing element inside the binding cavities of cross-linked MIP particles, and immobilized it on a carbon paste electrode (CPE), to develop a versatile electrochemical MIP (e-MIP) sensing receptor for the detection of benzo[a]pyrene (BaP) by measuring the redox tracer signal, as illustrated in Fig. 18B.…”

Section: Chemical and Biological Sensingmentioning

confidence: 99%

“…518 For example, Kubota et al 519 prepared an amperometric sensor employing a hemin-MIP particles modified glassy carbon . However, for nonelectroactive molecules, competitive measurements can be employed by the electroactive competitor recognition for the detection of targets, or by the addition of electroactive materials such as potassium ferricyanide 520 and vinylferrocene 521 as signal probes to electrolyte systems. Fig.…”

Section: Chemical and Biological Sensingmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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“…MIPs have been recognized as artificial recognition materials, which possess binding sites complementary in size and shape to templates for specific recognition of target molecules [24][25][26]. Besides excellent recognition property, MIPs, especially nano-structured MIPs, have several advantages over their biological counterparts including low cost, easy preparation, durability to heat and pressure, storage stability and high rebinding capacity [27][28][29].…”

Section: Introductionmentioning

confidence: 99%