A Versatile Strategy for Surface Functionalization of Hydrophobic Nanoparticle by Boronic Acid Modified Polymerizable Diacetylene Derivatives

Abstract

The flourishing advancements in nanotechnology significantly boost their application in biomedical fields. Whereas, inorganic nanomaterials are normally prepared and capped with hydrophobic ligands, which require essential surface modification to increase their biocompatibility and endow extra functions. Phenylboronic acid derivatives have long been known for its capacity for selective recognition of saccharides. Herein, we demonstrated a versatile surface modification strategy to directly convert hydrophobic inorganic nanocrystals into water-dispersible and targeting nanocomposites by employing boronic acid modified photo-polymerizable 10,12-pentacosadiynoicacid and further explore its potentials in selective cancer cell imaging.

Intratumoral Glutathione Activatable Nanoprobes for Fluorescence and 19F Magnetic Resonance Turn-On Imaging

“…AgInS 2 QDs were prepared through a previously published method with slight modification . As shown in Figure a, the TEM and HRTEM images showed that the average size of AgInS 2 QDs was around 4.0 nm, with a clear lattice spacing of 0.33 nm, well consistent with the (112) facet of the tetragonal AgInS 2 phase observed by XRD patterns (Figure S1).…”

“…All animal experiments and treatments were approved by the local ethics review committee and conducted in accordance with the guidelines of the Animal Care and Use Committee of Beijing University of Chemical ■ RESULTS AND DISCUSSION AgInS 2 QDs were prepared through a previously published method with slight modification. 35 As shown in Figure 1a, the TEM and HRTEM images showed that the average size of AgInS 2 QDs was around 4.0 nm, with a clear lattice spacing of 0.33 nm, well consistent with the (112) facet of the tetragonal AgInS 2 phase observed by XRD patterns (Figure S1). 36 The acquired hydrophobic AgInS 2 QD suspension displayed intense fluorescence with maximal emission at 654 nm (Figure 1b).…”

Design of Fluorinated Probes for Versatile Surface Functionalization and 19F Magnetic Resonance Imaging

“…The preparation of hydrophobic Ag nanoparticles, ZnS capped CuInS 2 nanoparticles (ZCIS NPs) used in this work referred to the previous report of our group, and had been slightly mobilized [17a] …”

Drug Delivery Systems in Regenerative Medicine: An Updated Review

“…Furthermore, these structures’ unique magnetic and radioactive characteristics permit their use in diagnostic and imaging applications [ 172 ]. They also possess several advantages, such as good biocompatibility and versatility for surface functionalization [ 173 ]. However, the low solubility and the possible toxic effect put some limitations on the clinical applications of inorganic NP [ 174 ].…”