A vessel of progress: Aortic microcalcification activity for the quantification of 18F-NaF uptake in the thoracic aorta

Osborne, Michael T.; Abbasi, Taimur; Zureigat, Hadil; Tawakol, Ahmed

doi:10.1007/s12350-021-02557-2

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Cited by 2 publications

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“… 12 The potential of aortic 18 F-sodium fluoride activity to assess thoracic aortic atherosclerotic disease progression and to predict downstream clinical outcomes is unknown. 13 , 14 …”

mentioning

confidence: 99%

Thoracic Aortic 18F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease

Fletcher

Tew

Tzolos

et al. 2022

JACC: Cardiovascular Imaging

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“… 12 The potential of aortic 18 F-sodium fluoride activity to assess thoracic aortic atherosclerotic disease progression and to predict downstream clinical outcomes is unknown. 13 , 14 …”

mentioning

confidence: 99%

Thoracic Aortic 18F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease

Fletcher

Tew

Tzolos

et al. 2022

JACC: Cardiovascular Imaging

View full text Add to dashboard Cite

“…Collectively, these data suggest that combinations of statin, exercise, aspirin, and diet may in fact prevent early-phase arterial wall NaF uptake ( Figure 3 ). The two articles on vitamin-K1 treatment in diabetic patients showed diverging results: initially no change in coronary or aortic NaF uptake [ 46 ], but later, using a newly defined, potentially questionable [ 54 ], upper limit of normal for TBRmax, the vitamin-K1 groups had decreased odds of developing new NaF positive lesions [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

NaF-PET Imaging of Atherosclerosis Burden

et al. 2023

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The method of 18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) of atherosclerosis was introduced 12 years ago. This approach is particularly interesting because it demonstrates microcalcification as an incipient sign of atherosclerosis before the development of arterial wall macrocalcification detectable by CT. However, this method has not yet found its place in the clinical routine. The more exact association between NaF uptake and future arterial calcification is not fully understood, and it remains unclear to what extent NaF-PET may replace or significantly improve clinical cardiovascular risk scoring. The first 10 years of publications in the field were characterized by heterogeneity at multiple levels, and it is not clear how the method may contribute to triage and management of patients with atherosclerosis, including monitoring effects of anti-atherosclerosis intervention. The present review summarizes findings from the recent 2¾ years including the ability of NaF-PET imaging to assess disease progress and evaluate response to treatment. Despite valuable new information, pertinent questions remain unanswered, not least due to a pronounced lack of standardization within the field and of well-designed long-term studies illuminating the natural history of atherosclerosis and effects of intervention.

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A vessel of progress: Aortic microcalcification activity for the quantification of 18F-NaF uptake in the thoracic aorta

Cited by 2 publications

References 18 publications

Thoracic Aortic 18F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease

Thoracic Aortic 18F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease

NaF-PET Imaging of Atherosclerosis Burden

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