A Visible‐Light‐Mediated Protocol: One‐Pot‐Three‐Component, Sustainable Synthesis of 1,3,4‐Thiadiazines

Abstract

An expeditious and proficient pH dependent, multicomponent strategy assisted by visible light for the synthesis of highly biologically significant scaffold "1,3,4-thiadiazines" and its derivatives, has been reported here. The hallmark of the present protocol is the utilization of visible light at room temperature to form CÀ S and CÀ N bond via generation of some free radical intermediates followed by intramolecular cyclization without employing harsh reaction conditions. It also includes some other attributes like being environmentally benign and cost effective, involving short reaction time and possessing adaptability towards a wide range of substrates with good to excellent yield of product.

Visible-light-induced C–S bond formation in the synthesis of 2,4-disubstituted thiazoles through cascade difunctionalization of acetophenone: a greener approach

“…This may be due to the separation process of photocatalysts or the instability of the product in the presence of photocatalysts. 48 The reaction was also carried out using the conventional method, refluxing in water without blue light, which gave only 70% yield of the product (Table 1, entry 14). After that, the reaction was carried out in the dark, but we did not get any yield of the product, showing the significance of light irradiation in this reaction (Table 1, entry 15).…”

Potentiating‐antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi‐drug resistant (MDR) strains

“…Thiadiazines are heterocyclic compounds that contain two nitrogen atoms and one sulfur atom in their structure [11]. These synthetic molecules have several relevant pharmacological activities, such as antifungal [12], antibacterial [10], and antiparasitic [13].…”